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1.
Christos Loizou Göran Laurell Andreas Arvidsson David Lindquist Karin Nylander Katarina Olofsson 《Acta oto-laryngologica》2015,135(10):1058-1064
Conclusion: Recurrent respiratory papillomatosis (RRP) patients with high surgical treatment frequency (≥ 1/year, HF) were significantly younger and had a more widespread laryngeal disease compared to a low frequency treated group (< 1 treatment/year, LF). This study confirms the existence of a clinical RRP group, not primarily related to HPV sub-type, but more care-intensive and in need of more vigilant follow-up. Objectives: RRP is associated with high morbidity due to its influence on breathing and voice. The purpose of this study was to characterize RRP patients in northern Sweden and investigate possible predictor factors affecting therapeutic needs. Method: Patients from the regional referral area (northern Sweden) were categorized for age, disease duration, juvenile or adult onset, profile of disease development, number of surgical sessions in relation to disease duration, laryngeal deposition of papilloma, gender, and HPV sub-types, in order to identify patients with increased need for frequent surgical treatment. Results: The median age of the RRP patients (n = 48) was 44.5 years; 34 (71%) were males and 14 (29%) females, most were infected with HPV 6. Patients with high surgical treatment frequency/year were significantly younger and showed more widespread papillomatous vegetation in the larynx, compared to the low frequency treated group. 相似文献
2.
D Gröne† R Treudler† EM de Villiers‡ R Husak† CE Orfanos† ChC Zouboulis†§ 《Journal of the European Academy of Dermatology and Venereology》2006,20(2):202-205
Cidofovir is an acyclic nucleoside phosphonate with broad-spectrum activity against DNA viruses, including human papilloma virus (HPV). However, data on the efficacy of cidofovir in an immunosuppressive setting remain contradictory. We report for the first time on the promotion of the healing of recalcitrant warts in a patient with myelodysplastic syndrome with intravenous cidofovir treatment. 相似文献
3.
Choroid plexus papillomas (CPPs) are typically considered as benign tumors, with a favorable long-term prognosis. Drop metastasis of CPP into the spinal subarachnoid space is rare. We report a 42-year-old woman who presented with headache and back pain 6 years after removal of a posterior fossa CPP. Magnetic resonance imaging revealed mass lesions in the lumbosacral subarachnoid space and recurrent intracranial tumor. The lesions were resected and histologically diagnosed was CPP. We consider that CPP can spread via cerebrospinal fluid pathways and cause spinal drop metastasis. Therefore, it is necessary to evaluate the whole spinal axis and to perform periodic follow-up examinations in patients with CPP. 相似文献
4.
Masujiro Makita MD Futoshi Akiyama MD Naoya Gomi MD Takuji Iwase MD Fujio Kasumi MD Goi Sakamoto MD 《The breast journal》2006,12(S2):S210-S217
Abstract: To improve the utility of mammary ductoscopy, we investigated the correlation between endoscopic findings and histologic findings using intraductal biopsy specimens. Seventy-one intraductal biopsy specimens obtained from 63 patients between October 2001 and March 2004 were analyzed retrospectively. All specimens were obtained from monotonous intraductal lesions immediately after observation by mammary ductoscopy and were composed of a pure histologic subtype. With regard to endoscopic findings, color was classified as yellow, red, white, or colorless, and morphology was classified as spherical, lobular, mulberry, or amorphous. The histologic subtype was classified as papillotubular, papillary, degenerated, papillary cancer, solid-type ductal carcinoma in situ (DCIS), or cribriform cancer. The relationship between histologic diagnosis, color, and morphology was investigated. Intraductal biopsy specimens included 25 specimens of carcinoma and 46 specimens of papilloma. There was no significant correlation between color and diagnosis. Fourteen of 25 carcinoma specimens were amorphous, and amorphous morphology was significantly suggestive of malignancy (p < 0.001). Further, cribriform cancer was associated with amorphous morphology and yellow color. Morphology may be a useful endoscopically delineated parameter for differentiating intraductal lesions. 相似文献
5.
R. L. Cabrini A. E. Schwint A. Mendez F. Femopase H. Lanfranchi M. E. Itoiz 《Journal of oral pathology & medicine》1992,21(6):275-279
A morphometric study of nucleolar organizer regions (NOR) was performed to analyze their distribution, volume, number and shape in the different strata of human normal oral mucosa epithelium and papilloma and in squamous cell carcinoma employing microphotographs of silver-stained paraffin sections. The different NOR-related parameters evidenced significant differences between normal mucosa, papilloma and squamous cell carcinoma. The functional polarity of normal mucosa epithelium and of papilloma is also evidenced in terms of NOR-related parameters. The discriminative value of certain NOR parameters was demonstrated. 相似文献
6.
聚合酶链反应检测尖锐湿疣皮损内人乳头瘤病毒 总被引:7,自引:0,他引:7
13个皮损组织取自13例尖锐湿疣(CA)患者,13例基底细胞上皮瘤(BCC)组织作为对照,用溴化钠液分离表真皮,从组织中提出的 DNA和溴化钠液分别用聚合酶链反应检测 HPV DNA。11例CA表皮中检出 HPV DNA,HPV6有7例,HPV11有4例。3例CA真皮中发现有HPV DNA,HPV6有2例,HPV11有1例。2例标本因溴化钠液被HPV污染未作统计。在BCC组织中未发现有HPV DNA。在某些CA真皮内含有 HPV DNA可以解释散发病例的复发性。 相似文献
7.
目的探讨婴幼儿复发性喉乳头状瘤的观察与护理。方法对33例婴幼儿复发性喉乳头状瘤患儿密切观察病情,以赢取抢救机会;进行有效的术前术后护理,包括完善术前准备和进行术前护理评估及术后并发症的预防、气管切开术后呼吸道管理等。结果33例中31例均好转出院,2例病情变化抢救无效死亡。结论婴幼儿复发性喉乳头状瘤患儿的术前、术后观察与护理对及时发现患儿病情变化,进行有效的抢救措施至关重要。 相似文献
8.
本文应用ABC法对30例尖锐湿疣(CA)和30例宫颈癌(CCU)进行原位观察,分析对比两者浸润单一核细胞(MNC)的亚群组成、分布及活化状态。结果提示,两者局部免疫均受抑制,而以宫颈癌为甚。依此本文对不同类型HPV相关疾病的局部免疫反应状态及宿主对不同型别HPV感染的免疫反应进行探讨。 相似文献
9.
目的 研究雌激素联合保妇康栓治疗绝经后宫颈人乳头瘤病毒(HPV)感染的临床疗效。方法 选取2019年2月—2022年7月无锡市第九人民医院收治的89例绝经后宫颈HPV感染患者,按治疗方法不同分为研究组(46例)和对照组(43例)。对照组接受雌激素治疗,研究组在对照组基础上接受保妇康栓治疗。两组均持续治疗3个月。对比两组异常分泌物持续时间、HPV转阴时间、临床疗效、炎症因子、免疫功能、液基薄层细胞学检查(LCT)评分与宫颈炎症评分及不良反应。结果 研究组异常分泌物持续时间、HPV转阴时间均短于对照组(P <0.05)。研究组总有效率高于对照组(P <0.05)。研究组治疗前后白细胞介素-4、γ干扰素、白细胞介素-2、肿瘤坏死因子-α的差值均高于对照组(P <0.05)。研究组治疗前后CD3+、CD19+、CD3+CD8+、CD3-CD56+的差值均高于对照组(P <0.05)。研究组治疗前后LCT评分、宫颈炎症评分的差值均高于对照组(P <0.05)... 相似文献
10.
Preservation and redirection of HPV16E7-specific T cell receptors for immunotherapy of cervical cancer 总被引:6,自引:0,他引:6
Scholten KB Schreurs MW Ruizendaal JJ Kueter EW Kramer D Veenbergen S Meijer CJ Hooijberg E 《Clinical immunology (Orlando, Fla.)》2005,114(2):119-129
Human papilloma virus (HPV) type 16 infections of the genital tract are associated with the development of cervical cancer (CxCa) in women. HPV16-derived oncoproteins E6 and E7 are expressed constitutively in these lesions and might therefore be attractive candidates for T-cell-mediated adoptive immunotherapy. However, the low precursor frequency of HPV16E7-specific T cells in patients and healthy donors hampers routine isolation of these cells for adoptive transfer. To overcome this problem, we have isolated T cell receptor (TCR) genes from four different HPV16E7-specific healthy donor and patient-derived human cytotoxic T lymphocyte (CTL) clones. We examined whether genetic engineering of peripheral blood-derived CD8+ T cells in order to express HPV16E711-20-specific TCRs is feasible for adoptive transfer purposes. Reporter cells (Jurkat/MA) carrying a transgenic TCR were shown to bind relevant but not irrelevant tetramers. Moreover, these TCR-transgenic Jurkat/MA cells showed reactivity towards relevant target cells, indicating proper functional activity of the TCRs isolated from already available T cell clones. We next introduced an HPV16E711-20-specific TCR into blood-derived, CD8+ recipient T cells. Transgenic CTL clones stained positive for tetramers presenting the relevant HPV16E711-20 epitope and biological activity of the TCR in transduced CTL was confirmed by lytic activity and by interferon (IFN)-gamma secretion upon antigen-specific stimulation. Importantly, we show recognition of the endogenously processed and HLA-A2 presented HPV16E711-20 CTL epitope by A9-TCR-transgenic T cells. Collectively, our data indicate that HPV16E7 TCR gene transfer is feasible as an alternative strategy to generate human HPV16E7-specific T cells for the treatment of patients suffering from cervical cancer and other HPV16-induced malignancies. 相似文献