全文获取类型
收费全文 | 44篇 |
免费 | 2篇 |
国内免费 | 8篇 |
专业分类
基础医学 | 3篇 |
口腔科学 | 1篇 |
临床医学 | 8篇 |
内科学 | 1篇 |
皮肤病学 | 1篇 |
特种医学 | 1篇 |
外科学 | 5篇 |
综合类 | 13篇 |
预防医学 | 2篇 |
眼科学 | 5篇 |
药学 | 11篇 |
中国医学 | 2篇 |
肿瘤学 | 1篇 |
出版年
2022年 | 2篇 |
2019年 | 2篇 |
2018年 | 1篇 |
2016年 | 1篇 |
2015年 | 2篇 |
2013年 | 2篇 |
2012年 | 4篇 |
2011年 | 3篇 |
2010年 | 6篇 |
2008年 | 2篇 |
2007年 | 4篇 |
2006年 | 4篇 |
2005年 | 2篇 |
2004年 | 2篇 |
2003年 | 3篇 |
2002年 | 3篇 |
2001年 | 4篇 |
2000年 | 1篇 |
1999年 | 1篇 |
1998年 | 2篇 |
1997年 | 1篇 |
1993年 | 1篇 |
1992年 | 1篇 |
排序方式: 共有54条查询结果,搜索用时 15 毫秒
1.
pSVPoMcat微基因修饰雪旺细胞移植对损伤脊髓功能恢复的影响 总被引:1,自引:1,他引:0
目的观察pSVPoMcat微基因修饰雪旺细胞(SC)移植对损伤脊髓功能恢复的影响. 方法采用切割法制备脊髓半横断损伤模型(T8平面),实验动物随机植入pSVPoMcat微基因的 SC组(A组)、SC组(B组)和明胶海绵组(C组),每组10只.用皮层体感诱发电位(CSEP) 及图像分析方法比较各组间诱发电位潜伏期、波幅,再生轴突计数.同时,行电镜观察及联合行为(CBS)记分. 结果 A,B两组潜伏期和波幅呈恢复趋势,且A组已接近正常,与CBS结果一致.再生轴突计数A组为388±163,B组为109±16(P<0.01),与电镜观察一致. 结论 pSVPoMcat微基因修饰SC移植对脊髓损伤(SCI)后的神经功能恢复有明显的促进作用. 相似文献
2.
手性修饰的硼氢化钠对前手性酮的不对称还原 总被引:3,自引:0,他引:3
研究了以N-苄基-(3S,4S)-3,4-二羟基四氢吡咯修饰的硼氢化钠对前手性酮的不对称还原反应,合成了五个光学活性醇,同时研究了添加路易斯酸对还原反应光学产率的影响。 相似文献
3.
改良的羟基磷灰石义眼座植入术 总被引:5,自引:2,他引:5
目的 寻求眼内容摘除术后义眼座植入的最佳手术方法。方法 将内直肌缝标记线并于附着处剪断 ,常规眼内容摘除后 ,将羟基磷灰石义眼座从内侧放入巩膜壳后肌锥内 ,复位内直肌 ,分层缝合。结果 3 8例患者术后反应轻 ,未发现有义眼座暴露、脱出等并发症 ,结膜囊腔光滑、宽阔 ,放置义眼后水平方向活动达 15°~ 2 5° ,垂直方向活动达 10°~ 15°。结论 该术式操作简便 ,患者痛苦小 ,术后反应轻 ,恢复快 ,美容效果好。 相似文献
4.
5.
Bohan Li Shuling Liu Yongmei Wang Jie Zhao Yang Song Wen Xu Cheng Zhang Chunzheng Gao Qian Zhao Dongjin Wu 《Medicine》2022,101(5)
The appearance of atherosclerosis in the carotid artery may be suggest the possibility of atherosclerosis in the spinal cord artery, which can cause spinal cord ischemia and further lead to neural element damage.According to the inclusion and exclude standard, there are 137 patients with cervical spondylotic myelopathy (CSM) incorporating retrospective analysis. These patients were consecutively admitted into The Second Hospital- Cheeloo College of Medicine-Shandong University from January 2016 to December 2018 and have accepted surgical treatment. All patients were examined by color Doppler ultrasound to detect carotid atherosclerosis before surgery. All patients were divided into 2 groups according to the presence or absence of carotid atherosclerosis: carotid atherosclerosis group (n = 88) and noncarotid atherosclerosis group (n = 49). All patients were followed up for at least 12 months after surgery. Demographic and surgery-related data were collected and analyzed to identify potential factors that affect the surgical outcomes in CSM.The average age of carotid atherosclerosis group (51 males and 37 females), and noncarotid atherosclerosis group (24 males and 25 females) were 62.02 ± 10.34 years (range, 38–85 years) and 49.61 ± 10.28 years (range, 26–67 years), respectively.In carotid atherosclerosis group: pre and postoperative modify Japanese Orthopedic Association Scores (mJOA score) were 11.58 ± 1.82 and 14.36 ± 1.64; the recovery rate of mJOA score was 45.57% ± 13.28%. In noncarotid atherosclerosis group: pre and postoperative mJOA score were 12.00 ± 2.11 and 15.04 ± 1.70; the recovery rate of mJOA score was 53.90% ± 13.22%. Univariate logistic regression analysis demonstrated that gender (P = .004), age ≥65 years (P = .001), duration of symptoms ≥12 months (P = .040), smoking history (P < .001), preoperative mJOA score ≤11 (P = .007) and carotid atherosclerosis (P = .004) were related to poor surgical outcomes. Multivariate logistic regression analysis showed significant correlations between poor surgical outcomes and age ≥65 years (P = .047), smoking history (P = .010), preoperative mJOA score ≤11 (P = .008) or carotid atherosclerosis (P = .047).Carotid atherosclerosis may be a risk factor for poor surgical outcomes in CSM. 相似文献
6.
Genetherapyofspinalcordinjury(SCI)remainsintheexper-imentalstage.Now,neurotrophicfactortomodifySchwanncell(SC)orfibroblastsareimplantedintoSCIregiontoobservetheregenera-tionsofaxons犤1犦.WefirstbuildPo-5'-flankinginducedmicrogeneforbasicproteinofmyelinsheathwhichistransientlynamedaspSVPoMcat.ThepSVPoMcatgenewasintroducedintoSCthroughcationliposome.ItwasprovedthatpSVPoMcatcouldenhancefunc-tionofSCandelongateitssurvivalperiodinvitro犤2犦.pSVPoMcatwasimplantedintoS… 相似文献
7.
目的 对黄槿中6种天然倍半萜类成分进行衍生化改造,并对所得衍生物进行体外抗肿瘤活性评价,分析其构效关系。方法 选取各种芳胺对黄槿中发现的6种倍半萜成分进行席夫碱修饰,采用噻唑蓝(MTT)法考察合成的目标化合物对HeLa、HepG2和MCG-803细胞的体外抗增殖活性。结果 衍生改造了19个不同的倍半萜类衍生物,结合1H-NMR、13C-NMR、HR-MS确定其结构,其中17个衍生物首次得到。部分衍生物表现出良好的抗肿瘤活性,苄胺基团对此类骨架化合物的结构修饰能够较好地提高其抗肿瘤活性。结论 部分衍生物表现出良好的抗肿瘤活性,特别对HepG2细胞活性有较大的提高,化合物12、22、23具有进一步研究价值。 相似文献
8.
Ho-Young Hwang In-San Kim Ick Chan Kwon Yong-Hee Kim 《Journal of controlled release》2008,128(1):23-31
Hydrophobically modified glycol chitosan (HGC) nanoparticles, a new nano-sized drug carrier, were prepared by introducing a hydrophobic molecule, cholanic acid, to water soluble glycol chitosan. The HGC nanoparticles were easily loaded with the anticancer drug docetaxel (DTX) using a dialysis method, and the resulting docetaxel-loaded HGC (DTX-HGC) nanoparticles formed spontaneously self-assembled aggregates with a mean diameter of 350 nm in aqueous condition. The DTX-HGC nanoparticles were well dispersed and stable for 2 weeks under physiological conditions (pH 7.4 and 37°C) and a sustained drug release profile, in vitro. In addition, the DTX-HGC nanoparticles were reasonably stable in the presence of excess bovine serum albumin, which suggested that the DTX-HGC nanoparticles might also be stable in the blood stream. The DTX-HGC nanoparticles exhibited a distinctive deformability in aqueous conditions, in that they could easily pass through a filter membrane with 200 nm pores despite their mean diameter of 350 nm. We also evaluated the time-dependent excretion profile, in vivo biodistribution, prolonged circulation time, and tumor targeting ability of DTX-HGC nanoparticles by using a non-invasive live animal imaging technology. Finally, under optimal conditions for cancer therapy, the DTX-HGC nanoparticles showed higher antitumor efficacy such as reduced tumor volume and increased survival rate in A549 lung cancer cells-bearing mice and strongly reduced the anticancer drug toxicity compared to that of free DTX in tumor-bearing mice. Together our results showed that the anticancer loaded nano-sized drug carriers are a promising nano-sized drug formulation for cancer therapy. 相似文献
9.
张静 《河北医科大学学报》1992,(1)
本文将玻碳电极置于pH8磷酸氢二钠—柠檬酸缓冲溶液(含0.5mol/L Na_2SO_4)中,加电压+1.8V(Vs·SCE)5分钟,-1.5V(Vs.SCE)30秒,制成电修饰电极。电修饰电极对芳香环有机化合物具有吸附作用,且吸附力随着芳香环的增多而加强,芳香环上取代基大小、位置影响吸附的强弱;该电极对VitC、NADH_2、多巴胺、扑热息痛和磺胺甲基异噁唑具有强的催化作用。 相似文献
10.
Daniel G. Amen M.D. Diane Highum M.D. Robert Licata M.D. Joseph A. Annibali M.D. Lillian Somner D.O. H. Edmund Pigott Ph.D. 《Journal of psychoactive drugs》2013,45(2):96-106
Abstract Our objective was to ascertain in a prospective case series how often brain single photon emission computed tomography (SPECT) neuroimaging adds relevant information for diagnosis and/or treatment beyond current standard assessment tools in complex psychiatric cases. Charts of 109 consecutively evaluated outpatients from four psychiatrics clinics that routinely utilize SPECT imaging for complex cases were analyzed in two stages. In stage one, psychiatrists reviewed detailed clinical histories, mental status exams, and the Structured Clinical Interview for DSM-IV, but not the results of SPECT studies, assigned a diagnosis based on DSM-IV criteria, and then developed a comprehensive treatment plan. In stage two, evaluators were given access to the SPECT studies for each patient. The addition of SPECT modified the diagnosis or treatment plan in 78.9% (n = 86; rated level 2 or 3 change) of cases. The most clinically significant changes were undetected brain trauma (22.9%), toxicity patterns (22.9%) and the need for a structural imaging study (9.2%). Specific functional abnormalities were seen as follows that potentially could impact treatment: temporal lobe dysfunction (66.1%) and prefrontal hypoperfusion (47.7%). SPECT has the potential to add clinically meaningful information to enhance patient care beyond current assessment tools in complex or treatment resistant cases. 相似文献