肉豆蔻提取物对GaIN致大鼠急性肝损伤的保护作用

肉豆蔻属肉豆蔻科(Myristica fragrans)植物的种子.近年来文献报道肉豆蔻提取物可增强对肿瘤的免疫功能、破坏癌细胞外围防护因子,使癌组织容易被损害,有消炎、止痛、抗栓塞及抗凝作用[1,2].本文主要观察豆蔻乙醇提取物对GaIN致大鼠急性肝损伤的保护作用,并初步探讨其作用机制.     

沙棘籽油对肝损伤小鼠免疫功能的影响

目的：研究沙棘籽油的对肝损伤小鼠免疫功能的影响。方法：采用D－半乳糖胺造成小鼠肝损伤模型，观察沙棘籽油对正常及肝损伤小鼠免疫功能的影响。结果：沙棘籽油使正常和D－GalN致肝损伤小鼠腹腔巨噬细胞吞噬功能，血清溶菌酶活性，脾淋巴细胞转化和IL－2活性增强。结论：沙棘籽油能增强小鼠的免疫功能。     

异甘草酸镁对D-氨基半乳糖急性肝损伤模型小鼠的保护作用研究

目的研究异甘草酸镁对D-氨基半乳糖急性肝损伤模型小鼠的保护作用。方法以D-氨基半乳糖建立小鼠急性肝损伤模型,分别设正常对照组、病理模型组、异甘草酸镁高、低剂量组以及美能组、易善复组、凯西莱组,测定各组小鼠血清中丙氨酸氨基转移酶(ALT)、天门冬酸氨基转移酶(AST)活性及肝组织中丙二醛(MDA)、黄嘌呤氧化酶(XOD)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-PX)、总抗氧化能力(T-AOC)、一氧化氮(NO)、一氧化氮合成酶(NOS)、诱生型一氧化氮合酶(iNOS)含量。另以HE染色,采用光镜对各组小鼠肝脏作病理检查。结果异甘草酸镁可明显降低ALT、AST的活性(P<0.01)及肝组织中MDA、XOD、NO、NOS、iNOS的含量;升高肝组织中SOD、GSH-PX、T-AOC的含量。光镜下可观察到异甘草酸镁能减轻小鼠肝脏坏死性病理改变。结论异甘草酸镁对D-氨基半乳糖诱导的小鼠急性肝损伤具有良好的保护作用。     

IL-17 and IL-17-producing cells and liver diseases,with focus on autoimmune liver diseases

The pro-inflammatory cytokine interleukin(IL)-17 and IL-17-producing cells are important players in the pathogenesis of many autoimmune / inflammatory diseases. More recently, they have been associated with liver diseases. This review first describes the general knowledge on IL-17 and IL-17 producing cells. The second part describes the in vitro and in vivo effects of IL-17 on liver cells and the contribution of IL-17 producing cells to liver diseases. IL-17 induces immune cell infiltration and liver damage driving to hepatic inflammation and fibrosis and contributes to autoimmune liver diseases. The circulating levels of IL-17 and the frequency of IL-17-producing cells are elevated in a variety of acute and chronic liver diseases. The last part focuses on the effects of IL-17 deletion or neutralization in various murine models. Some of these observed beneficial effects suggest that targeting the IL-17 axis could be a new therapeutic strategy to prevent chronicity and progression of various liver diseases.