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Nashwa Jarkas Ronald J. Voll Mark M. Goodman 《Journal of labelled compounds & radiopharmaceuticals》2013,56(11):539-543
[18F]2‐Fluoroethyl‐p‐toluenesulfonate also called [18F]2‐fluoroethyl tosylate has been widely used for labeling radioligands for positron emission tomography (PET). [18F]2‐Fluoroethyl‐4‐bromobenzenesulfonate, also called [18F]2‐fluoroethyl brosylate ([18F]F(CH2)2OBs), was used as an alternative radiolabeling agent to prepare [18F]FEOHOMADAM, a fluoroethoxy derivative of HOMADAM, by O‐fluoroethylating the phenolic precursor. Purified by reverse‐phase HPLC, the no‐carrier‐added [18F]F(CH2)2OBs was obtained in an average radiochemical yield (RCY) of 35%. The reaction of the purified and dried [18F]F(CH2)2OBs with the phenolic precursor was performed by heating in DMF and successfully produced [18F]FEOHOMADAM, after HPLC purification, in RCY of 21%. Copyright © 2013 John Wiley & Sons, Ltd. 相似文献
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