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2.
A. Farina 《Journal of pharmaceutical and biomedical analysis》1989,7(12):1579-1583
A simple and rapid fluorimetric method for the determination of 9-fluoro-10-[N-(4′-methyl)piperazinyl]-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-d,e][1–4]benzothyazin-6-carboxylic acid hydrochloride (MF 934), in serum and in pharmaceutical formulations, has been developed based on its strong fluorescence, in 0.1 N H2SO4, at 526 nm (excitation wavelength at 340 nm). The procedure which involves the direct dilution of the sample requires only a few minutes and the sample volume is only 20–100 μl of serum, depending on the drug concentration. Tedious sample preparation procedures such as extraction, deproteinization, or centrifugation are not necessary. The minimum concentration that can be detected is 0.3 ng ml−1, the standard curve in 0.1 N H2SO4 was found to be linear from 0.005 to 1.5 μg ml−1 and from 0.01 to 0.07 g in plasma after dilution with 0.1 N H2SO4. 相似文献
3.
厄贝沙坦治疗高血压患者的临床效果观察 总被引:1,自引:0,他引:1
目的:观察厄贝沙坦治疗高血压患者的临床效果。方法:选择2007年1月~2009年1月来本院就诊的高血压患者200例,随机分为两组,厄贝沙坦组100例,采用厄贝沙坦治疗4周;对照组100例采用依那普利治疗,观察患者用药前后动态血压、心脏功能变化,并评价临床疗效。结果:厄贝沙坦组患者治疗总有效率为97%,均未出现明显不良反应:与对照组比较.差异有统计学意义,P〈0.05。厄贝沙坦组治疗后24h、白昼和夜间平均收缩压和舒张压与治疗前比较,差异有统计学意义,P〈0.05;用药后血压晨峰也显著降低,与治疗前比较,差异有统计学意义,P〈0.05:但与对照组间比较,差异无统计学意义,P〉0.05。结论:厄贝沙坦治疗高血压疗效满意,安全性较高,还可降低患者的心脑血管意外的风险。 相似文献
4.
Cheryce M. Poon M.D. Robert A. Koenigsberg D.O. Betsy A. Izes M.D. 《Emergency radiology》1997,4(5):264-267
Angioedema of the oropharynx and hypopharynx due to oral angiotensin-converting enzyme (ACE) inhibitors is a potentially life-threatening event and has not been well described in the radiology literature. A retrospective review of the clinical and radiologic findings in three patients with angioedema due to ACE inhibitor use was performed.Our subgroup of patients treated with ACE inhibitors presented with varying degrees of dysphagia, dyspnea, and facial swelling. Plain radiographic findings included enlargement of the epiglottis, aryepiglottic folds, and prevertebral and submental soft tissue. Computed tomography confirmed extensive retropharyngeal and subcutaneous edema. Clinical symptoms resolved in each case in 24–48 hours with cessation of the ACE inhibitor and concomitant steriod therapy.Our cases demonstrate the typical clinical and radiographic presentation of neck angioedema in the setting of ACE inhibitor use. As ACE inhibitors are increasingly being used as first-line agents in the treatment of hypertension, we caution that neck angioedema may be encountered with increased frequency in adults. Early recognition and immediate intervention result in rapid resolution of this potentially life-threatening event. 相似文献
5.
本文报告应用新的转换酶抑制剂依那普利(enalapril)治疗59例原发性高血压的临床疗效。采甩随机单盲及双盲法进行,对照药为巯甲丙脯酸。结果表明:依那普利使收缩压及舒张压均降低10%以上(由21.5±1.6/13.8±0.9kPa降至19.2±2.2/12.3±1.0kPa),总有效率为74.2%,与巯甲丙脯酸相仿,但前者作用持续时间显著延长。半数患者的有效剂量为10mg/d,80%在20mg/d以下。本药对血像、肝肾功能、血电解质及糖、脂类代谢未见明显影响。 相似文献
6.
Renoprotective effects of combination of angiotensin converting enzyme inhibitor with mycophenolate mofetil in diabetic rats 总被引:2,自引:0,他引:2
Y. -G. Wu H. Lin H Qian M. Zhao X. -M. Qi G. -Z. Wu S. -T. Lin 《Inflammation research》2006,55(5):192-199
Objective and design Previously it was shown that blocking of the renin-angiotensin system (RAS) by angiotensin converting enzyme (ACE) inhibitors,
or suppression of inflammatory responses by immunosuppressive drugs such as mycophenolate mofetil (MMF) could attenuate renal
injury in diabetic rats. Whether RAS blockade combined with an immunosuppressive drug provides superior renoprotection against
diabetic nephropathy has not been clearly delineated.
Materials Diabetes was induced by injection of streptozotocin after uninephrectomy.
Treatment Rats were randomly separated into five groups: control, diabetes, diabetes treated with enalapril (an ACE inhibitor, 10 mg/kg/d
by gastric gavage), diabetes treated with MMF (10 mg/kg/d by gastric gavage), or diabetes treated with a combination of both
agents and were followed for 8 weeks.
Methods 24 h urinary albumin excretion rate (AER) was determined, renal injury was evaluated, immunohistochemistry for ED-1 macrophage
marker, intercellular adhesion molecule-1 (ICAM-1) and monocyte chemoattractant protein-1 (MCP-1) were performed, and expression
of transforming growth factor (TGF)-β1 protein was determined by Western blotting analysis.
Results Diabetes was associated with a considerable increase in AER. Both enalapril and MMF retarded the increase in albuminuria,
which was nearly completely abrogated by combination therapy. Increased glomerular volume and tubulointerstitial injury index
in diabetic rats was attenuated by treatment with either enalapril or MMF and further reduced by the combination of the two.
Elevated malondialdehyde levels in renal tissue were reduced by enalapril or MMF and, more effectively, by combined enalapril
with MMF. Renal overexpression of ICAM-1 was not retarded by enalapril and attenuated by MMF or combined enalapril with MMF.
Combination therapy was associated with a superior suppression of diabetes-induced macrophage recruitment and overexpression
of MCP-1 and TGFβ1 compared to either monotherapy in renal tissue.
Conclusion The combination of enalapril and MMF confers superiority over monotherapy in renoprotection, a mechanism which may be at least
partly correlated with synergistic suppression of increased macrophage recruitment and overexpression of MCP-1 and TGF-β1
in renal tissue in diabetic rats.
Received 26 July 2005; returned for revision 5 October 2005; returned for final revision 9 January 2006; accepted by M. Katori
23 January 2006 相似文献
7.
8.
Eleven acetylsalicylic acid (ASA) formulations were administered to 26 healthy volunteers in a cross-over design. The properties of the preparations differed from conventional, effervescent, buffered to buccal. The objectives of this study were:
- 1 Consideration of the general aspects of a biopharmaceutical study: which parameter for which biopharmaceutic characteristic?
- 2 Measurement of the kinetic parameters of ASA: first-pass effect, mean residence time, mean appearance time, total body clearance, apparent volume of distribution, half-lives, etc.
- 3 Comparison of the formulations.
9.
10.
目的:了解依那普利辅助治疗肺心病心衰的疗效。方法:在抗炎、改善通气基础上观察加用依那普利后心衰改善情况。结果:依那普利组与对照组相比肺心病心衰症状改善明显,心率下降明显,而血压无明显变化。结论:依那普利可改善肺心病心衰,提高生活质量。 相似文献