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1.
目的 探讨晕可宁颗粒的主要药效学 ,为临床提供药效学资料及治疗学基础。方法 采用三氯甲烷破坏豚鼠一侧膜迷路感受器模型 ,探讨受试药对眼震颤、摆头及旋转的影响 ;采用内淋巴囊和内淋巴管阻塞手术复制豚鼠膜迷路实验性膜迷路积水模型 ,研究内耳组织平均中阶面积 (SMA)增加率及形态学的变化。结果 抑眩宁阳性对照组、晕可宁颗粒 (8、16g/kg)模型给药组豚鼠眼球震颤次数减少 ,差异有显著意义 (P <0 .0 5 )。成功复制了不同程度膜迷路积水豚鼠模型 ,表现为前庭膜重度膨出 ,前庭阶缩小 ,膜蜗管增大 ,SMA增加率变大 ,差异有显著意义 (P <0 .0 1) ;晕可宁颗粒灌胃后可减轻豚鼠实验性膜迷路积水的程度 ,差异有显著意义 (P <0 .0 1) ;但与空白对照组比较SMA增加率差异无显著意义 (P >0 .0 5 )。结论 晕可宁颗粒可以减轻内淋巴囊积水程度 ,对梅尼埃病症状有对抗治疗作用。 相似文献
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Regarding the burden of mental disorders in elderly patients, including morbidity and mortality, especially by suicide, and impairment of quality of life and functional autonomy, there is a need to take into account special health care needs of elderly persons. In bipolar disorders, lithium tends to be under-prescribed in elderly patients, while it is still a first line choice in guidelines. If it is true that there is a lack of controlled studies on effectiveness of lithium in elderly patients, available data from lithium side effects, especially on renal function, don’t justify this under-utilization. Moreover, anti-inflammatory and neuroprotective effects of lithium may be of particular interest in ageing, in preventing and/or controlling the occurrence of some neurodegenerative process. 相似文献
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Cosmetics are products, which by definition “…must not damage human health in the normal conditions of use”. However, unwanted effects do occur, the best known being cutaneous and allergic reactions. The dermatology-allergy specialist is thus the first to be concerned with cosmetovigilance. In 1966, the Groupe d’études et de recherche en dermato-allergologie (GERDA) created a vigilance network concerned with cutaneous allergic incidents [Réseau de vigilance sur les accidents allergiques cutanés (REVIDAL)], the REVIDAL GERDA, which acts as a coordinator for cosmetovigilance. In 2004, a public cosmetovigilance committee was created; all serious adverse effects or those appearing to be serious were to be reported immediately to the Agence française de sécurité sanitaire des produits de santé (AFSSAPS) by health professionals who observed them. Manufacturers are required to participate in this public cosmetovigilance. They have a similar responsibility via the Direction générale de la concurrence et de la consommation (DGCCRF) to report to AFSSAPS the list of their products which contain substances for which there is a serious doubt. This means that cosmetovigilance requires collection of cases; it will work well only if reports are made regularly. The physician who reports cases improves the management of his patients and participates in Public Health actions. This type of cosmetovigilance will extend to all EU countries. Reports by consumers should be possible, but they will be encouraged to consult a doctor before doing so. 相似文献
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Longueville C Doffoel-Hantz V Hantz S Souyri N Nouaille Y Bédane C Sparsa A 《La Revue de médecine interne / fondée ... par la Société nationale francaise de médecine interne》2012,33(3):e17-e18
Erythema nodosum is a panniculitis occurring more frequently in young women. We report a 16-year-old woman who presented with erythema nodosum that occurred following Gardasil® administration (vaccine against HPV types 6, 11, 16 and 18) and that is proposed to young female. This adverse effect is not a contraindication to the HPV vaccination because its benefit against the oncogene risk of Papillomavirus is documented. 相似文献