全文获取类型
收费全文 | 3446篇 |
免费 | 125篇 |
国内免费 | 57篇 |
专业分类
耳鼻咽喉 | 16篇 |
儿科学 | 20篇 |
妇产科学 | 144篇 |
基础医学 | 308篇 |
口腔科学 | 80篇 |
临床医学 | 242篇 |
内科学 | 231篇 |
皮肤病学 | 14篇 |
神经病学 | 208篇 |
特种医学 | 46篇 |
外科学 | 409篇 |
综合类 | 336篇 |
预防医学 | 170篇 |
眼科学 | 14篇 |
药学 | 1091篇 |
中国医学 | 273篇 |
肿瘤学 | 26篇 |
出版年
2023年 | 39篇 |
2022年 | 66篇 |
2021年 | 98篇 |
2020年 | 54篇 |
2019年 | 82篇 |
2018年 | 98篇 |
2017年 | 86篇 |
2016年 | 96篇 |
2015年 | 106篇 |
2014年 | 234篇 |
2013年 | 370篇 |
2012年 | 212篇 |
2011年 | 287篇 |
2010年 | 161篇 |
2009年 | 197篇 |
2008年 | 214篇 |
2007年 | 181篇 |
2006年 | 117篇 |
2005年 | 98篇 |
2004年 | 89篇 |
2003年 | 78篇 |
2002年 | 70篇 |
2001年 | 49篇 |
2000年 | 57篇 |
1999年 | 29篇 |
1998年 | 36篇 |
1997年 | 32篇 |
1996年 | 40篇 |
1995年 | 31篇 |
1994年 | 33篇 |
1993年 | 15篇 |
1992年 | 28篇 |
1991年 | 17篇 |
1990年 | 17篇 |
1989年 | 8篇 |
1988年 | 15篇 |
1987年 | 16篇 |
1986年 | 20篇 |
1985年 | 13篇 |
1984年 | 16篇 |
1983年 | 7篇 |
1982年 | 11篇 |
1981年 | 9篇 |
1977年 | 8篇 |
1975年 | 10篇 |
1974年 | 16篇 |
1973年 | 12篇 |
1972年 | 10篇 |
1971年 | 6篇 |
1970年 | 6篇 |
排序方式: 共有3628条查询结果,搜索用时 312 毫秒
1.
2.
Sarah Hallas Andrea Nelson Susan O'Meara Una Adderley Pauline Meskell Jane Nixon Aonghus O'Loughlin Sebastian Probst Wael Tawfick Thomas Wild Georgina Gethin 《Journal of tissue viability》2021,30(3):317-323
BackgroundA venous leg ulcer is a chronic leg wound caused by poor venous blood circulation in the lower limbs. It is a recurring condition causing pain, malodour, reduced mobility, and depression. Randomised controlled trials evaluating treatments for venous leg ulcers provide important evidence to inform clinical decision-making. However, for findings to be useful, outcomes need to be clinically meaningful, consistently reported across trials, and fully reported. Research has identified the large number of outcomes reported in venous leg ulcer trials, impacting both synthesis of results, and clinical decision-making. To address this, a core outcome set will be developed. A core outcome set is an agreed standardised set of outcomes which should be, as a minimum, measured and reported in all trials which evaluate treatment effectiveness for a given indication. A core outcome set has the potential to reduce research waste, improve the utility of RCTs, reduce reporting bias, facilitate treatment comparisons across different sources of evidence and expedite the production of systematic reviews, meta-analyses and evidence-based clinical guidelines.AimThe aim of this project is to develop a core outcome set for research evaluating the effectiveness of interventions for treating venous leg ulceration.MethodsThrough a scoping review of the literature on venous leg ulceration, we will firstly identify a list of candidate outcome domains (broad categories in relation to what is being measured) from randomised controlled trials and qualitative research, and outcomes (specific methods in relation to what is being measured). In two further stages, we will use the resulting lists of outcome domains and outcomes to design two online surveys. A range of stakeholders will be invited to participate in the surveys and they will be asked to indicate which outcome domains and outcomes are most important and should be considered as core in future research reports. 相似文献
3.
《Clinical neurophysiology》2019,130(8):1311-1319
ObjectiveUnder General Anesthesia (GA), age and Burst Suppression (BS) are associated with cognitive postoperative complications, yet how these parameters are related to per-operative EEG and hypnotic doses is unclear. In this prospective study, we address this question comparing age and BS occurrences with a new score (BPTIVA) based on Propofol doses, EEG and alpha-band power spectral densities, evaluated for SEF95 = 8–13 Hz.Methods59 patients (55 [34–67] yr, 67% female) undergoing neuroradiology or orthopedic surgery were included. Total IntraVenous Anesthesia was used for Propofol and analgesics infusion. Cerebral activity was monitored from a frontal electrodes montage EEG.ResultsBPTIVA was inversely correlated with age (Pearson r = −0.78, p < 0.001), and was significantly lower (p < 0.001) when BS occurred during the GA first minutes (induction). Additionally, the age-free BPTIVA score was better associated with BS at induction than age (AUC = 0.94 versus 0.82, p < 0.05).ConclusionWe designed BPTIVA score based on hypnotics and EEG. It was correlated with age yet was better associated to BS occurring during GA induction, the latter being a cerebral fragility sign.SignificanceThis advocate for an approach based on evaluating the cerebral physiological age (« brain age ») to predict postoperative cognitive evolution. 相似文献
4.
评估控制性卵巢刺激中预测卵巢反应性的指标 总被引:1,自引:0,他引:1
在辅助生育技术的实施中,控制性卵巢刺激(COS)方案是根据患者情况确定的,在用药剂量和启动时间的掌握上非常重要。由于卵巢本身反应性或基础状态的不同,不同年龄及不同病因的患者有着极大的差异,用量适当可避免因启动剂量过大造成卵巢过度剌激(OHSS),或剂量过少造成低反应,卵泡 相似文献
5.
目的分别应用三针锁针加压器外固定和空心拉力钉内固定疗法治疗股骨颈骨折,探讨股骨颈骨折最佳治疗方法.方法应用三针锁针加压器外固定治疗股骨颈骨折63例,其中男24例,女39例;年龄55~89岁,平均(64.5±3.2)岁;Garderl Ⅰ型2例,Ⅱ型15例,Ⅲ型38例,Ⅳ型8例.应用空心拉力钉内固定治疗63例,其中男29例,女34例;年龄45~76岁,平均(62.2±2.9)岁;Garden Ⅰ型4例,Ⅱ型24例,Ⅲ型28例,Ⅳ型7例.对其疗效进行分析.结果126例除2例死亡外均得到随访.115例愈合,其中10例股骨头坏死.外固定组愈合58例,股骨头坏死4例,死亡1例;内固定组愈合57例,股骨头坏死6例,死亡1例.根据Harris功能评定标准评价疗效,外固定组62例中优24例,良26例,可8例,差4例,优良率80.65%;内固定组62例中优23例,良27例,可6例,差6例,优良率80.65%.Harris评分外固定组平均(80.40±1.21)分,内固定组平均(79.14±1.47)分,两组Harris评分比较差异无统计学意义(P>0.05).结论采用内外固定治疗股骨颈骨折疗效无明显差异,但外固定创伤小、费用低、可早期离床;而采用拉力钉内固定器医疗成本高,卧病时间相对较长,且需二次手术取内固定钉. 相似文献
6.
目的:对照回顾性分析带锁髓内钉和钢板内固定两种方法治疗胫骨干骨折的效果。方法:髓内钉组32例(35处骨折),根据AO分型,42A型11处,42B型18处,42C型6处;钢板组42例(45处骨折),42A型10处,42B型22处,42C型13处。平均伤后手术时间在髓内钉和钢板组分别为3d和3.5d。随访评估患者手术时间,活动度,愈合时间,术后并发症之间的差别。结果:术后平均随访13个月(8~26个月)。髓内钉组平均手术时间为84min,钢板螺钉组平均为93min。髓内钉组踝关节平均背屈度为13°(0°~20°),钢板组为11°(0°~20°);跖屈分别为41°(30°~50°),47°(30°~50°)。愈合时间髓内钉组平均为3.3个月,钢板螺钉平均为3.5个月。术后X线片显示髓内钉固定有1例出现旋转畸形,钢板组有3例出现成角畸形,均为胫骨远端1/3骨折。结论:在治疗胫骨骨折方面,带锁髓内钉和钢板内固定两种方法都可以取得理想的效果。 相似文献
7.
纸夹板内收位固定与石膏外展位固定治疗Bennett骨折的随机对照试验 总被引:2,自引:0,他引:2
目的:研究比较纸夹板内收位固定与石膏外展位固定治疗Bennett骨折的疗效差异。方法:选择2005年10月至2007年4月门诊就诊的70例Bennett骨折患者,按区组随机的方法分为试验组35例(纸夹板内收位固定)和对照组35例(石膏外展位固定)进行治疗。骨折达到临床愈合拆除固定后,对患者进行为期6个月的随访观察。分别于骨折后6、8、12、16、20及24周按改良的Gabriele评分系统对其患手功能进行量化评分比较。结果:两组的优良率在8、12、16及20周时比较试验组优于对照组,差异有统计学意义(P〈0.05);6周和24周时比较差异无统计学意义(P〉0.05)。两组在功能评分方面,8、12、16、20及24周时比较试验组高于对照组,差异有统计学意义(P〈0.05);6周时积分差异无统计学意义(P〉0.05)。结论:在Bennett骨折的治疗中,纸夹板内收位固定与石膏外展位固定相比能明显加快患手功能的恢复,而且固定轻便、舒适,患者易于接受,可以作为一种有效的固定方法在临床推广。 相似文献
8.
Clinical Efficacy of New Antiepileptic Drugs in Refractory Partial Epilepsy: Experience in the United States With Three Novel Drugs 总被引:1,自引:1,他引:0
Jacqueline A. French 《Epilepsia》1996,37(S2):S23-S26
Summary: A number of new antiepileptic drugs (AEDs), including topiramate (TPM), felbamate (FBM), and gabapentin (GBP), are approved or believed to be close to approval for marketing in the United States. Key efficacy findings for these AEDs in refractory partial epilepsy were reviewed. Large and significant drug-placebo differences were observed with TPM in two large dose-finding trials conducted in the United States. The minimal effective dose of TPM in the population studied was determined to be approximately 200 mg/day, and doses above 600 mg/day produced good efficacy but little incremental benefit versus the lower dosages for the overall study population. FBM is active in partial epilepsy, although seizure reduction is less marked and drug interactions complicate the findings. GBP is also active in this population, but only the 1,800 mg/day dosage was significantly better than placebo with respect to percent re-sponders. It may be useful to explore higher dosage ranges for both FBM and GBP if they can be well tolerated. 相似文献
9.
脑络康缓释胶囊的制备工艺和体外释放度的研究 总被引:4,自引:0,他引:4
以羟丙甲基纤维素作为主要的缓释辅料,采用正交设计方法优化处方研制成脑络康缓释胶囊.以人参皂苷的累积释放量作为考察指标,按照<药典>规定的缓释制剂的释放度进行优选.结果:最佳的处方工艺即羟丙甲基纤维素216 mg,乙基纤维素24 mg,混合稀释剂132 mg,释放曲线符合Higuchi动力学模型. 相似文献
10.
In rabbit platelet rich plasma (PRP), 5-hydroxytraptamine (5-HT,0.03~3μmol/L) induced decrease in light transmission (DLT) dose-de pendently with centralization, as revealed by electron microscopy. However, 5-HT did not induced platelet aggregation and release reaction. 5-HT-induced DLT was inhibited by methysergide (0.3~30μmol/L), indomethacin (0.3~10μmol/L) and PGE_1 (0.01~0.3μmol/L) in a dose-dependent manner, but not EGTA(0.3~3mmol/L). Collagen(Coll), arachidonic acid (AA), adenosine diphosphate (ADP) and a stable thromboxane A2 analoge(STA_2) also induced DLT before aggregation by themselves, which was also inhibited by PGE_1, but not inhibited by EGTA except for Coll However,Coll-, AA-, STA_2-and ADP-induced DLT were reduced by pretreatment of PRP with 5-HT dose-depen-dently. The duration of DLT by Coll and AA were decreased from 151.4±5.93 sec and 15(?)38±0.60sec to 45.44±4.04 sec and 9.00±1.25 sec respectively ((?)±s(?) P<0.01), but not by ADP and STA_2, 3μmol/L of ADP-and 0.3μmol/L of STA_2-induced aggregation which was not accompanied with release reaction were enhanced by 5-HT pretreatment, but in those (Coil 5μg/ml, AA 100~200μmol/L and STA_2 1~3 μmol/L) with release reaction, the amount of adenosine triphosphate(ATP)were suppressed significantly (P<0.001) by 5-HT pretreatment without the effect on the magnitude of aggregation, The mobilization of cytosolic free calcium concentration ([Ca~(2+)]i) was observed after 5-HT treatment in single washed platelet, the results indicated that the basic level of [Ca~(2+)] i was 64.78±3.24nmol/L and this level was increased dose-dependently and significantly at 30 sec after administration of 5-HT and the time of peak value of [Ca~(2+)] i was at 90~100 sec.The similar time courses of suppression of ATP released during aggregation, in cases of Coll(5μg/ml), AA (200μmol/L) and STA_2(3μmol/L), by 5-HT were also found in the present experiment. 相似文献