Lichen Striatus Occurring after Allogenic Peripheral Blood Stem Cell Transplantation in an Adult with Aplastic Anemia

Lichens striatus (LS) is an acquired, self-limiting inflammatory dermatosis that follows the lines of Blaschko. The etiology of the eruption is unknown, but several theories have been proposed with focus on environmental factors, viral infection, cutaneous injury, hypersensitivity, and genetic predisposition. We describe a 19-year-old woman who developed a unilateral linear eruption 17 months after allogenic peripheral blood stem cell transplantation. Histopathology revealed features, which were consistent with LS. To the best of our knowledge, our patient is the first case describing the appearance of LS occurring after allogenic stem cell transplantation. We speculate that this condition represents an unusual form of localized, chronic graft-versus-host disease.     

皮肤共聚焦激光扫描显微镜在儿童色素减退性疾病诊断中的应用

目的 探讨儿童常见色素减退性疾病皮肤共聚焦激光扫描显微镜(CLSM)图像的基本特征.方法 分别观察1 915例色素减退性疾病(包括白癜风、特发性滴状色素减少症、无色素痣、线状苔藓、白色糠疹及炎症后色素减退)患者的皮损,用CLSM观察皮损处、交界处及白斑周边正常皮肤的各层镜下特征.应用卡方检验和Fisher精确检验进行统计学分析.结果 1级和2级色素减少占总病例数的51.4％(984/1 915)和35.7％(684/1 915),白癜风3级色素减少的比例为77.9％(141/181),明显高于其他疾病(0～ 10.3％);815例角质层轻度角化过度,1 060例棘层灶性水肿,79例基底细胞环出现改变,1 133例真皮浅层可见稀疏炎症细胞或树枝状细胞.6种色素减退性皮肤病CLSM扫描图像色素减少程度及各层CLSM图像变化均有统计学差异(P＜0.05).CLSM特征:特发性滴状色素减少症可见色素环完全缺失;线状苔藓、白色糠疹、炎症后色素减退可见非特异性炎症改变,线状苔藓可见点灶状基底细胞液化变性;无色素痣仅为色素减少及折光变弱,白癜风白斑区色素完全缺失,且皮肤色素环缺乏完整性.结论 白癜风、特发性滴状色素减少症、无色素痣、线状苔藓、白色糠疹及炎症后色素减退皮损CLSM图像有差异,可以作为鉴别诊断的依据之一.     

Induction of micronuclei and nuclear lesions in Channa punctatus following exposure to carbosulfan,glyphosate and atrazine

Abstract

The genotoxic effects of commonly used agricultural pesticides viz., carbosulfan, glyphosate, and atrazine, were evaluated in Channa punctatus (Pisces, Perciformes) using micronucleus (MN) test and induction of nuclear lesions (NL). The 96?h LC₅₀ value were estimated by probit analysis as 0.27, 32.0 and 42.0?mg?L^?1, respectively, for carbosulfan, glyphosate, and atrazine using semi-static bioassays. Based on these values, three sublethal test concentrations of carbosulfan (0.07, 0.13, 0.20?mg?L^?1), glyphosate (8.1, 16.3, 24.4?mg?L^?1) and atrazine (10.6, 21.2, 31.8?mg?L^?1) corresponding to ¼, ½ and ¾ of the LC₅₀ of the pesticides respectively, were selected for exposure for 96?h. Peripheral blood samplings were taken at intervals of 24?h for assessment of MN and NL frequencies. Considerably higher genotoxic damage was induced by carbosulfan as compared to glyphosate and atrazine. There were significant effects (p?<?0.01) of concentrations in all the treated groups. The induction of MN and NL was highest at 96?h pesticide exposure at all test concentrations. The nuclear abnormalities recorded in this study, such as blebbed-, lobed-, notched- and bi-nuclei, other than micronuclei, are indicators of genotoxic damage.     

Residues of Organochlorine Pesticides in Fish from the Gomti River,India

This study reports the levels and distribution patterns of some organochlorine pesticides (OCPs) in fish samples of the Gomti river, India, collected from three sites. In the fish muscles ∑OCPs ranged between 2.58–22.56 ng g⁻¹ (mean value: 9.66 ± 5.60 ng g⁻¹). Neither spatial nor temporal trends could be observed in distribution of the OCPs. Aldrin was the predominant OCP, whereas, HCB and methoxychlor could not be detected. α-HCH and β-HCH among the isomers of HCH and pp-DDE among the metabolites of DDT were the most frequently detected OCPs. The results revealed that the fish of the Gomti river are contaminated with various OCPs.     

Lichen Striatus in an Adult

A 58-year-old Japanese woman with lichen striatus had asymptomatic multiple erythemato-papular plaques in arranged linear or band-like patterns over the right half side of her chest, back, and the right upper and lower extremities, following Blaschko's lines. A biopsy specimen demonstrated a dermoepidermal interface inflammation with a lichenoid lymphoid cell infiltrate into the upper and middle dermis. All lesions spontaneously cleared within 2 months. Lichen striatus in an adult should be differentiated from other acquired erythemato-papular dermatoses which may follow Blaschko's lines. Its histopathological features may mimic those of lichen planus, but it can be distinguished because of its consistent distribution on Blaschko's lines, not only in children but also in adults.     

Bilateral lichen striatus

We describe a very rare case of bilateral lichen striatus on the lower extremities with a history of more than ten years. Histopathologically, the lesions demonstrated a lichenoid tissue reaction with foci of spongiosis and perivascular inflammatory cell infiltration. In addition, the finding of lymphocytic infiltrations around the eccrine duct was observed. They were treated successfully with topical application of corticosteroid ointment. To the best of our knowledge, no other lichen striatus case has been reported with bilateral distribution and such long-term persistence.     

Three Cases of Lichen Nitidus Associated with Various Cutaneous Diseases

Lichen nitidus (LN) is an uncommon, usually asymptomatic cutaneous eruption characterized by the presence of multiple, small, flesh-colored papules. The epidemiologic and pathophysiologic characteristics of LN have not yet been defined. Furthermore, LN has rarely been described in association with other cutaneous diseases. We herein report 3 cases of LN associated with various cutaneous diseases, including lichen striatus, oral lichen planus, and psoriasis vulgaris.     

成人线状苔藓1例

患者女,44岁。左下肢及左侧腹股沟区丘疹伴轻微瘙痒3个月。皮肤科情况:左侧内踝、小腿内侧、大腿内侧以及腹股沟区大致沿Blaschko线纵形线状排列的红色丘疹。皮肤组织病理示表皮角化过度伴部分表皮角化不全,基底层液化变性,真皮全层小血管及附属器周围较多淋巴细胞浸润。诊断:成人线状苔藓。     

花栗鼠心电图的分析

目的:研究哺乳类冬眠动物花栗鼠(tamiasstriatus)的心电图特点。方法:用热笔式心电图机记录花栗鼠冬眠与非冬眠状态的心电图。结果:本实验得出花栗鼠的心电图特点为:①温暖季节,活泼花栗鼠的心电图P波与T波重叠无TP段,T波的初始部分与QRS波的末尾部分相接无ST段。此时额面QRS电轴方向为75～90°,平均心率为496次/分;②在冬季因为花栗鼠处于冬眠阵不同时相,其心电图发生很大变化。在花栗鼠处于冬眠阵的觉醒时相,其心电图也和温暖季节活泼花栗鼠的心电图不同。此时P波不再与T波重叠,额面QRS电轴方向约为70°,心率约为376次/分。而当花栗鼠深冬眠时,心电图各波电压较高,P波不与T波重叠有TP段,额面QRS电轴方向约为60°。此时T波的起始部分仍然和QRS波的末尾部分相接无ST段,心电图各部分均有锯齿波,出现心肌连续放电现象,心率约为75次/分。结论:温暖季节,活泼花栗鼠的心电图与大白鼠的心电图相似;在冬季由于花栗鼠处于冬眠阵不同时相,其心电图变化复杂,个体差异较大。