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排序方式: 共有260条查询结果,搜索用时 15 毫秒
1.
钙拮抗剂TMB-8抑制BHQ,NE和KCl引起的培养乳牛基底动脉单个平滑肌细胞内游离钙的升高 总被引:1,自引:0,他引:1
用AR CM MIC阳离子测定系统,测量单个细胞内游离钙浓度([Ca2+]i),研究8-(N,N-二乙胺)-n-辛基 3,4,5-三甲氧基苯甲酸酯(TMB-8)对培养乳牛基底动脉平滑肌[Ca2+]i的作用。在细胞外钙浓度为1.3mmol·L-1时,TMB-8(30μmol·L-1)可明显抑制BHQ,NE及KCl引起[Ca2+]i的升高。在细胞外钙为零+EGTA 0.1mmol·L-1时,TMB-8(10,30及100μmol·L-1)可浓度依赖性地降低静息[Ca2+]i,TMB-8(30μmol·L-1)可几乎完全阻断BHQ及NE引起[Ca2+]i的增加。研究表明TMB-8降低培养乳牛基底动脉平滑肌[Ca2+]i的机制,主要是抑制肌浆网Ca2+的释放,或增加肌浆网对Ca2+的摄入,并由此间接地抑制细胞外钙的内流。 相似文献
2.
目的探讨一种以腓肠神经内侧头肌支切断来改善小腿外形的新方法。方法在腘窝处切开,暴露腓肠神经内侧头肌支,并切断,使局部肌肉失神经萎缩,而缩小小腿的容积。结果本组4例,术后小腿周径平均缩小3.6±0.8cm,小腿外形满意。结论本方法为一简单、安全而有效的技术,能达到缩小小腿部的目的。 相似文献
3.
Actinomycetous infections typically involve either the head and neck or the extremities following a traumatic implantation.
Classic clinical associations are draining sinus tracts. This case report describes the pathologic and MR findings of a relatively
acute mycetomatous process involving the soft tissues. Pathologic findings in this case included an occasional granule composed
of gram positive, thin branching elements. These and other findings were consistent with actinomycetes bacterium infection.
The discussion centers around the use of MR, both with and without gadolinium, in evaluating this type of granulomatous infection.
Infiltration of the adjacent subcutaneous tissues was easier to appreciate on both the T1-weighted images without gadolinium
and the T1-weighted images with gadolinium when compared to the T2-weighted images. Signal characteristics as described in
this case report may suggest a granulomatous process. 相似文献
4.
Thirty college students were classified on the basis of cold-pressor blood pressure responses and then randomly assigned to one of three treatment groups. One group merely tracked a visual analog display of their heart rate (tracking group). A second group attempted to increase and decrease its heart rate without the visual display (no-feedback group). A third group attempted to increase and decrease their heart rates with the aid of the visual heart rate display (feedback group). Results indicated that the heart rate changes produced by both the feedback and no-feedback groups were significantly greater than those observed in the tracking group. There was no significant difference between the former two groups. Results also demonstrated that high cold-pressor reactors were able to produce significantly larger heart rate changes than the low reactor subjects. A correlational analysis of physiological responses accompanying heart rate change suggested that the response topographies of the high and low cold-pressor reactors differed as well. Finally, results indicated no relationship between coronary-prone personality characteristics, as measured by the Jenkins Activity Scale, and either cold-pressor reactivity or heart rate control performance. 相似文献
5.
The instability of membrane markers expressed by human monocytes and macrophages in culture 总被引:2,自引:0,他引:2
Surface markers were tested on freshly isolated human monocytes and following their in vitro maturation to macrophages. The markers tested were HLA-DR antigens, receptors for the Fc of IgG and complement as well as membrane markers defined by monoclonal antibodies. The results revealed a dynamic expression of some of the markers on monocytes which was influenced by several variables. The expression of the markers was modulated by the presence of different sera, by treatment with lymphokines and interferon and following the in vitro maturation of monocytes to macrophages. The most unstable marker was found to be the HLA-DR, which was modulated by all these variables. The 63D3 was affected by different sera and culture supernatant, as well as following the maturation of monocytes to macrophages, but not by lymphokines and interferon. One of the markers, the Mac 120, was found to be relatively stable and did not change significantly following the maturation of monocytes to macrophages. The Fc and complement receptors were also stable in their expression under these conditions, but were probably partially blocked in the presence of human serum. These results indicated that at least some of the heterogeneity related to the monocyte population was probably not due to the occurrence of stable subsets of cells, but rather to reversible changes in marker expression. 相似文献
6.
We examined putative autonomic and hemodynamic mechanisms that might explain our prior finding that cardiorespiratory fitness mitigates blood pressure responses by normotensive women during the hand cold pressor test. We report that fitness level was inversely related to increases in systolic and diastolic blood pressures and muscle sympathetic nerve activity (MSNA) during the cold pressor among women but not men. The pattern of responses among fitter women was consistent with decreased central sympathetic outflow resulting in reduced stroke volume or dampened peripheral resistance in vascular beds other than calf skeletal muscle. Fitter men and women had slightly larger increases in blood pressure during mental arithmetic, but otherwise fitness was not directly related to stress responses. The results further encourage consideration of cardiorespiratory fitness as a modifying covariate when the hand cold pressor test is used as a predictor of future hypertension among women. 相似文献
7.
Gajdosik RL 《European journal of applied physiology》2002,87(3):220-227
The purpose of this study was to use a model of aging to examine the relationships between passive properties of the calf
muscles and plantarflexion concentric isokinetic torque characteristics. Eighty-one active women 20–84 years of age were tested
using a Kin-Com isokinetic dynamometer interfaced with electromyography (EMG). The passive properties were tested by stretching
the muscles from relaxed plantarflexion to a maximal dorsiflexion (DF) angle at a rate of 5°·s–1 (0.087 rad·s–1) with minimal raw EMG activity (<0.05 mV). The maximal concentric torque was tested from maximal passive DF into plantarflexion
at four randomly ordered velocities of 30, 60, 120, and 180°·s–1. Pearson correlation coefficients (Bonferroni adjusted) indicated a hierarchical order of high to moderate positive correlations
between four passive properties and the peak and mean concentric torque for all test velocities. Correlation coefficients
for the four passive properties ranged from 0.50 to 0.78 (P<0.001), and the coefficients of determination (r
2) from higher to lower were: (1) maximal DF passive resistive torque (r
2: 0.50–0.62), (2) length extensibility (r
2: 0.40–0.49), (3) maximal muscle length (r
2: 0.28–0.41), and (4) passive elastic stiffness in the last half of the full-stretch range of motion (r
2: 0.25–0.31). The maximal DF passive resistive torque and the length extensibility accounted for 50–62% and 40–49% of the
variability in the concentric torque, respectively. The results indicate that the concentrically stronger calf muscles of
active women were positively correlated with passively stronger, longer, and stiffer calf muscles, which are characteristics
of the calf muscles of younger women. Further studies are needed to examine whether therapeutic interventions, such as stretching
and strengthening, can promote adaptations in the calf muscles of older women to attain these more youthful characteristics.
Electronic Publication 相似文献
8.
Yi-Han Mo Jing Zhong Xin Dong Yi-Dong Su Wen-Yu Deng Xue-Mei Yao Bei-Bei Liu Xiao-Qin Wang Xiu-Hua Wang 《Journal of the American Medical Directors Association》2021,22(4):746-750.e1
ObjectiveThe 2019 Asian Working Group on Sarcopenia in Older People (AWGS 2019) recommends using either calf circumference or the strength, assistance in walking, rising from a chair, climbing stairs, and falls (SARC-F) or SARC-F combined with calf circumference (SARC-CalF) questionnaires for sarcopenia screening. The aim of this study was to compare the ability and applicability of calf circumference, SARC-F, and SARC-CalF for screening sarcopenia among community-dwelling older adults.DesignCross-sectional study.Setting and ParticipantsA total of 1050 community-dwelling older people were enrolled.MethodsSarcopenia was diagnosed according to the AWGS 2019 criteria: bioimpedance analysis for appendicular skeletal muscle index, hand grip, and 6-m gait speed test. Participants also completed the SARC-F questionnaire and calf circumference measurement. The screening tools’ performances were evaluated through receiver operating characteristic (ROC) curves, area under the ROC curves (AUC), and sensitivity/specificity analyses.ResultsSarcopenia was identified in 263 (25.0%) participants by the AWGS 2019 criteria. Calf circumference had a sensitivity of 81.4% and a specificity of 77.0%. Sensitivity and specificity of SARC-F for screening sarcopenia were 17.9% and 93.7%, respectively. SARC-CalF improved the sensitivity of SARC-F (47.5%) while keeping similar specificity (92.0%). The AUCs of calf circumference, SARC-F, and SARC-CalF were 0.79 [95% confidence interval (CI), 0.77–0.82], 0.56 (95% CI, 0.52–0.59), and 0.70 (95% CI, 0.67–0.73), respectively. The differences across ROC curves were statistically significant among 3 screening tools (P < .001).Conclusions and ImplicationsThe overall screening ability of calf circumference was better than that of SARC-F and SARC-CalF for sarcopenia in community-dwelling older persons despite gender, age, and cognitive function. SARC-F and SARC-CalF have high specificity but are susceptible to the preceding factors. 相似文献
9.
Sprengel deformity is a rare orthopedic condition that is associated with functional and cosmetic impairment. Results of
orthopedic procedures are usually inconsistent and cosmetic results are far from satisfactory in these patients. A silicone-gel-filled
calf prosthesis was used to correct the shoulder contour in a patient with Sprengel deformity. Cosmetically the deformity
can be restored by using a calf implant for patients in whom orthopedic procedures are not likely to yield a satisfactory
outcome. 相似文献
10.
目的探讨注射用牛肺表面活性剂联合持续正压通气(CPAP)治疗早产儿特发性呼吸窘迫综合征(IRDS)的临床效果。方法以2010年3月~2013年6月本院收治的28例早产儿IRDS患者为研究对象,观察和比较治疗前后动脉血气指标以及CPAP参数的变化情况。结果患儿的临床症状明显改善,动脉血气指标和CPAP参数与用药前比较,差异有统计学意义(P〈0.05)。结论注射用牛肺表面活性剂联合CPAP治疗早产儿IRDS效果良好,可使患儿的症状、动脉血气指标、CPAP参数明显改善。 相似文献