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1.
《Journal of vascular and interventional radiology : JVIR》2020,31(6):986-992
PurposeTo assess the feasibility, safety, and efficacy of balloon-assisted delivery of ethylene vinyl alcohol copolymer (EVOH) for a range of peripheral arterial applications.Materials and MethodsSix academic medical centers entered retrospective data on 46 consecutive patients (27 men, 19 women; ages, 11–94 y; mean age, 50.3 y) who underwent 60 balloon-assisted EVOH procedures. The cohort was restricted to procedures involving peripheral, nonneural arteries 1–5.5 mm in diameter. Clinical indications included a wide range of vascular pathologic conditions (most commonly arteriovenous malformations [n = 20], renal angiomyolipomas [n = 8], and acute hemorrhage [n = 9]) and targeted visceral and musculoskeletal peripheral arteries. Data collected included sex, age, clinical indication, arterial pathology, arteries embolized, type of occlusion balloon microcatheter, type and concentration of EVOH agent, effectiveness as an embolic backstop, vessels protected, adequacy of EVOH cast penetration, catheter extraction, nontarget embolization, and complications.ResultsBalloon occlusion prevented EVOH reflux in 59 of 60 procedures (98.3%). Nontarget EVOH embolization occurred in 2 procedures (3.3%). Adequate EVOH cast penetration and complete filling of the target pathologic structure were seen in 57 of 60 procedures (95%). Balloon deflation and uneventful extraction occurred in all procedures; small EVOH fragments detached into target arteries in 2 cases. One major (1.7%) and 2 minor (3.3%) complications occurred.ConclusionsBalloon-assisted EVOH embolization of peripheral arteries is feasible, safe, effective, and versatile. The primary advantage of balloon-assisted EVOH embolization is the ability to apply more injection pressure to advance the EVOH cast assertively into the pathologic structure(s). 相似文献
2.
《Biomaterials》2015
The aim of this paper is to present a method to produce macroporous thin membranes made of poly (ethyl acrylate-co-hydroxyethyl acrylate) copolymer network with varying cross-linking density for cell transplantation and prosthesis fabrication. The manufacture process is based on template techniques and anisotropic pore collapse. Pore collapse was produced by swelling the membrane in acetone and subsequently drying and changing the solvent by water to produce 100 microns thick porous membranes. These very thin membranes are porous enough to hold cells to be transplanted to the organism or to be colonized by ingrowth from neighboring tissues in the organism, and they present sufficient tearing stress to be sutured with surgical thread. The obtained pore morphology was observed by Scanning Electron Microscope, and confocal laser microscopy. Mechanical properties were characterized by stress–strain experiments in tension and tearing strength measurements. Morphology and mechanical properties were related to the different initial thickness of the scaffold and the cross-linking density of the polymer network. Seeding efficiency and proliferation of mesenchymal stem cells inside the pore structure were determined at 2 h, 1, 7, 14 and 21 days from seeding. 相似文献
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利用石英弹簧称重法测定了308.15K时乙醇和苯在含端羟基聚丁二烯(HTPB)和端羟基聚丁二烯/丙烯腈共聚物(HTBN)的嵌段共聚聚氨酯膜中的吸收动力学曲线。结合吸收-络合吸附双模式传递模型,研究了聚氨酯膜的微相分离程度、软硬段的比例和组成以及软段分子量等因素对溶剂在膜中溶解和传递性质的影响。 相似文献
5.
E. Waris M. Pakkanen K. Lassila P. Törmälä Y. T. Konttinen R. Suuronen N. Ashammakhi 《European journal of plastic surgery》2003,26(7):350-355
A wide variety of biological and alloplastic injectable biomaterials are available for soft tissue augmentation, but the ideal material has not yet been discovered. Biological materials such as collagen and hyaluronan yield temporary results, while injectable alloplasts are apt to cause varying degrees of foreign body reactions that may result in lumps and chronic inflammation.We present two cases (one is the first filed case in the world) of migratory subcutaneous inflammatory masses secondary to injection of acrylic hydrogel (DermaLive), which is an alloplastic biomaterial recently introduced into the market in Europe. Histology revealed foreign body reaction to acrylic hydrogel with granuloma formation containing multinucleated giant cells. Following this, further reports on complications have been reported elsewhere in Europe. The use and development of injectable materials, as well as alternative methods and future directions are reviewed. 相似文献
6.
We have prepared a new material for embolisation: ethylene vinylacetate copolymer dissolved in polyvinyl alcohol. When in contact with blood, polyvinyl alcohol rapidly becomes a soft gel, which is accompanied by wedging of the ethylene vinylacetate copolymer. We analysed the histopathology of intra-arterial microemboli in rats, after intracarotid injection of this material. We confirmed that it was applicable to embolisation for neurosurgical treatment. 相似文献
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用分步乳液聚合法合成了具有核壳结构的胶乳互穿聚合物网络LIPN(PMMA-PS)/(Pn-BA-PAA);讨论了LIPN组成对乳液与膜性能的影响,提出了四元LIPN核壳结构的基本轮廓,探讨了软硬单体最佳配比及丙烯酸单体用量。 相似文献
9.
K. Wester 《Acta neurochirurgica》1994,131(3-4):223-225
Summary The results of a total of 25 cranioplasties are reported. In 10 patients, a reinforced acrylic prosthesis was utilized. In the remaining 15 cases, the patient's own autoclaved bone flap was re-implanted. Six of these bone flaps were autoclaved to kill tumour cells, and was re-implanted during the same surgical procedure. In the remaining 9 patients, the flaps were removed to allow brain swelling, preserved in a freezer and re-implanted several months later. All the prostheses and re-implanted flaps were accepted by the patients without complications such as infections or resorption, and with cosmetically satisfying results. The tumour infiltrated flaps remained tumour free for the entire period of observation. 相似文献
10.
目的:研究新型可降解聚合物聚乙二醇对苯二甲酸酯/聚对苯二甲酸丁二醇酯(PEGT/PBT)的人脐静脉内皮细胞(HUVEC)相容性,对其在组织工程血管中的应用进行探讨。方法:对PEGT/PBT进行细胞毒性评价。观察并检测HUVEC在PEGB/PBT、Ⅰ型胶原改性(Col-)的PEGT/PBT、纤维连接蛋白改性(Fn-)的PEGT/PBT上的粘附和增殖,对细胞在粘附过程中的粘着斑蛋白进行免疫荧光染色观察。结果:PEGT/PBT细胞毒性不大于1级,能支持脐静脉内皮细胞的粘附和增殖。纤维连接蛋白和Ⅰ型胶原处理可促进HLIVEC在PEGT/PBT膜上的增殖,而且纤维连接蛋白可增加HUVEC在PEGT/PBT上20min、2h的粘附率,并促进细胞形成局部粘附结构。结论:新型可降解聚合物PEGT/PBT具有良好的血管细胞相容性,对其在组织工程血管中的应用值得进一步开发研究。 相似文献