Terapia de luz pulsada intensa regulada: un tratamiento complementario prometedor para la enfermedad de ojo seco

ObjectiveTo propose the Intense Pulsed Light (IPL) therapy as a helpful supplementary treatment in patients with dry eye disease.Material and methodsRetrospective cross sectional design. Medical records of patients in whom dry eye disease symptoms were not satisfactorily controlled with medical therapy alone and who underwent additional IPL with at least three sessions completed. Data were analyzed before therapy and 3 weeks after its completion to asses improvement. Determination of symptoms, through a visual analog scale; tear film stability, through tear Break Up Time (tBUT); measurement of tear secretion, through Schirmer Test; and ocular surface staining with Van Bijsterveld score were evaluated. SPSS software and nonparametric analysis of repeated measures were used. The study was approved by the ethics committee.Results50 eyes from 25 subjects were reviewed. There were 9 males (36%) and 16 females (64%), with a median age of 59 years (IQR 52-64). The median of the symptoms scale was 8 (IQR 8-9) and 3 (IQR 2-4) before and after the therapy respectively (P < .05). The median of BUT was 4 (IQR 3-5) and 10 (IQR 8-11), Schirmer test was 13 (IQR 12-15) and 15 (IQR 13-20), and Van Bijsterveld score was 3 (RIC 3-4) and 2 (IQR 2-3) before and after the therapy respectively (P < .05, for all measurements).ConclusionIPL treatment has excellent results regarding both: dry eye disease symptoms improvement and in office objective tests such as tBUT, Schirmer test and Van Bijsterveld score; IPL could be considered as an effective adjunct for dry eye disease.     

Effects of Portulaca Oleracea on Insulin Resistance in Rats with Type 2 Diabetes Mellitus

Insulinresistance(IR)isthecommon patho physiologicalbasisforagroupofmetabolicabnormali tiescalledinsulinresistancesyndrome,whichin cludestype 2diabetesmellitus(T2DM),obesity,lipidmetabolicdisturbance,primaryhypertensionandatherosclerosis.ItwasoncereportedthataChinesemedicinalherb,Portulacaoleracea,usedalonecouldeffectivelytreatdiabetesmellitusinhumans(1) asithastheactionofamelioratinghyperlipidemia,andpreventingandcuringatherosclerosis(2,3).Butexper imentalstudyofPortulacaoleraceaoninsulinr…     

β‐benzene hexachloride induces apoptosis of rat sertoli cells through generation of reactive oxygen species and activation of JNKs and FasL

β‐benzene hexachloride (β‐BHC), the major metabolite of benzene‐hexachloride (BHC), is a weak estrogen‐like chemical. It is a known persistent organic pollutant and male reproductive toxicant. However, the mechanism by which β‐BHC exposure causes male reproductive toxicity remains unknown. In the present study, rat Sertoli cells were used to investigate the molecular mechanism involved in β‐BHC‐induced toxicity in male reproductive system. The results indicated that β‐BHC exposure at over 30 μM showed the induction of apoptotic cell death. β‐BHC could induce elevation in reactive oxygen species (ROS) generation, increase in the leakage rate of LDH and MDA level, and decrease in SOD activity. In addition, there was an increase in the cellular levels of phospho‐JNKs and FasL in the β‐BHC‐induced apoptosis; and a significant reduction of procaspase‐3 and ‐8 was observed over 30‐μM β‐BHC treatment. The translocation of NF‐κB enhanced with the increase of concentration of β‐BHC. Furthermore, NAC administration, a scavenger of ROS, reversed β‐BHC‐induced apoptosis effects via inhibition of JNKs activation, FasL expression, and NF‐κB translocation. These results lead us to speculate that ROS generation may play a critical role in the initiation of β‐BHC‐induced apoptosis by activation of the JNKs, translocation of NF‐κB, expression of FasL, and further activation of caspase cascade. © 2009 Wiley Periodicals, Inc. Environ Toxicol 26: 124–135, 2011.     

劳宫穴主治病症和配伍规律的古今对比研究

ObjectiveTo explore the clinical application rules of Láogōng (劳宫PC8) by analyzing the comparison and contrast of the practice with this acupoint in ancient times and in present.MethodsRelevant literature before October 1, 1949 was selected from Chinese Medical Code (Fifth Edition) and Compilation of Modern Chinese Medicine Journals and literature published after October 1, 1949 was screened from China National knowledge Infrastructure (CNIK), Wanfang Data Knowledge Service Platform (Wanfang), VIP Chinese Journal Service Platform (VIP), Chinese BioMedine Database (CBM), Pubmed Database, and Web of Science. After screening, SQL Server database was established. The complex network analysis was conducted by using Gephi and the cluster analysis was performed by SPSS Statistics.ResultsBefore October 1, 1949, Láogōng (劳宫PC8), on a single use or with a match of Dàlíng (大陵PC7), Guānyuán (关元CV4), and Zúsānl? (足三里ST36), was mainly used for treating ozostomia and edema due to pregnancy. However, Láogōng (劳宫PC8), on a single use or with a match of Y?ngquán (涌泉KI1), Hég? (合谷LI4) and Nèiguān (内关PC6) was commonly for the treatment of toothache and the sequelae after wind stroke after October 1st, 1949.ConclusionLáogōng (劳宫PC8) is mainly used to treat local disorders or diseases pertaining to the pericardium meridian. The single-point therapy was commonly applied before October 1st, 1949, while a combination of other points is more common afterwards and the scope of indication expands, with its application for psychiatry disorders, pain diseases and emergent diseases. Acupoints on the same meridian of Láogōng (劳宫PC8), ying-spring points, the back-shu points and combination between and the upper and the lower are dominated in the selection of supplementary points. The supplementary acupoints with the highest frequency of use were specific acupoints, including five-shu points, yuan-source points, front-mu points, etc.     

罗格列酮和血清脂对绵羊前体脂肪细胞分化的影响

目的探讨罗格列酮(rosiglitazone,Ros)和血清脂(serum lipid,Lip)对绵羊前体脂肪细胞分化的影响及不同组织来源的前体脂肪细胞分化影响的差异。方法用不同浓度的Ros和(或)Lip培养绵羊皮下前体脂肪细胞和肾周前体脂肪细胞,通过测量3-磷酸甘油脱氢酶(GPDH)活性和油红O染色萃取液A值分析前体脂肪细胞的分化程度和脂肪细胞充脂量的变化,应用实时荧光定量PCR检测PPARγ和LPL mRNA的表达水平。结果 Ros和Lip提高细胞GPDH活性和脂滴的沉积量(P<0.05),上调LPL mRNA表达(P<0.05),最佳浓度分别为100nmol/L和20μL/mL;最佳浓度条件下Ros的诱导作用强于Lip(P<0.05),Ros显著提高了PPARγmRNA表达量(P<0.05),而Lip对PPARγmRNA的表达没有明显影响(P>0.05);Ros和Lip共同诱导与Ros单独作用之间没有明显差异(P>0.05);在相同诱导分化条件下,皮下前体脂肪细胞的分化程度高于肾周前体脂肪细胞(P<0.05)。结论研究结果表明Ros和Lip可促进绵羊前体脂肪细胞的分化,在相同条件下,皮下前体脂肪细胞的分...     

针刺颈夹脊配合按摩点穴治疗颈性眩晕症65例(英文)

目的:观察针刺颈夹脊配合按摩点穴治疗颈性眩晕的临床疗效,为临床治疗颈性眩晕提供更优方法。方法:65例颈性眩晕患者针刺双侧颈夹脊、风池,强间透刺脑户、玉枕透刺天柱,并结合按摩点穴,每日治疗1次,16次为一疗程,共治疗2个疗程,观察患者的临床疗效。结果:治愈25例,占38.5%;显效18例,占27.7%;有效19例,占29.2%;无效3例,占4.6%。总有效率为95.4%。结论:针刺颈夹脊配合按摩点穴治疗可以很好地缓解颈性眩晕患者的临床症状。     

针刺治疗陈旧性外踝关节扭伤31例(英文)

目的:观察针刺对于陈旧性外踝关节扭伤的临床疗效。方法:选择31例陈旧性外踝扭伤患者,针刺患侧解溪穴透申脉、阳陵泉,留针30 min,针刺1次,1个月后随访。结果:31例患者均经过1次治疗即痊愈,随访1月未复发。结论:针刺治疗陈旧性外踝关节扭伤疗效显著。     

Granuloma aséptico facial idiopático: hallazgos clínicos y ecográficos de 3 casos

Idiopathic facial aseptic granuloma is a typical childhood disease characterized by the presence of one or more asymptomatic nodules on the cheek. Although pathogenesis remains unclear, the disease is thought to be a type of childhood rosacea. It resolves spontaneously, yet it could be confused with other lesions that require treatment.We present clinical and ultrasound findings and outcome from 3 new cases. In 2 cases, the lesion presented as childhood rosacea. Ultrasound revealed a characteristic pattern, with variations depending on the stage of development.High-frequency ultrasound can facilitate the differential diagnosis and thus obviate unnecessary biopsy or excision.     

Documento de consenso español para el algoritmo de tratamiento de la rosácea

Recent scientific evidence and the incorporation of new drugs into the therapeutic arsenal against rosacea have made it necessary to review and update treatment criteria and strategies. To this end, a panel of 15 dermatologists, all experts in rosacea, was formed to share experiences and discuss treatment options, response criteria, and changes to treatment. Based on a critical review of the literature and a discussion of the routine practices of Spanish dermatologists, the panel proposed and debated different options, with consideration of the experience of professionals and the preferences of patients or equality criteria. Following validation of the proposals, the final recommendations were formulated and, together with the evidence from the main international guidelines and studies, used to produce this consensus document. The goal of this consensus document is to provide dermatologists with practical recommendations for the management of rosacea.