全文获取类型
收费全文 | 1008篇 |
免费 | 55篇 |
国内免费 | 42篇 |
专业分类
耳鼻咽喉 | 5篇 |
儿科学 | 12篇 |
妇产科学 | 2篇 |
基础医学 | 118篇 |
口腔科学 | 2篇 |
临床医学 | 78篇 |
内科学 | 34篇 |
皮肤病学 | 22篇 |
神经病学 | 145篇 |
特种医学 | 109篇 |
外科学 | 10篇 |
综合类 | 131篇 |
预防医学 | 102篇 |
眼科学 | 2篇 |
药学 | 206篇 |
中国医学 | 124篇 |
肿瘤学 | 3篇 |
出版年
2024年 | 2篇 |
2023年 | 6篇 |
2022年 | 14篇 |
2021年 | 19篇 |
2020年 | 19篇 |
2019年 | 6篇 |
2018年 | 16篇 |
2017年 | 30篇 |
2016年 | 25篇 |
2015年 | 20篇 |
2014年 | 48篇 |
2013年 | 62篇 |
2012年 | 101篇 |
2011年 | 76篇 |
2010年 | 57篇 |
2009年 | 60篇 |
2008年 | 63篇 |
2007年 | 58篇 |
2006年 | 47篇 |
2005年 | 58篇 |
2004年 | 33篇 |
2003年 | 29篇 |
2002年 | 29篇 |
2001年 | 25篇 |
2000年 | 28篇 |
1999年 | 18篇 |
1998年 | 21篇 |
1997年 | 11篇 |
1996年 | 16篇 |
1995年 | 15篇 |
1994年 | 8篇 |
1993年 | 8篇 |
1992年 | 7篇 |
1991年 | 7篇 |
1990年 | 5篇 |
1989年 | 9篇 |
1988年 | 3篇 |
1987年 | 6篇 |
1986年 | 5篇 |
1985年 | 8篇 |
1984年 | 8篇 |
1983年 | 3篇 |
1982年 | 4篇 |
1981年 | 2篇 |
1980年 | 4篇 |
1979年 | 3篇 |
1978年 | 1篇 |
1976年 | 1篇 |
1971年 | 1篇 |
排序方式: 共有1105条查询结果,搜索用时 15 毫秒
1.
2.
Martine Hascoët Michel Bourin Jacques Bradwejn 《Progress in neuro-psychopharmacology & biological psychiatry》1991,15(6):825-840
1. The mechanism of action of drugs might change according to the test used. Several noradrenergic drugs were tested in order to understand their implication in the mobility tests.
2. It was found that clonidine, an Alpha 2 agonist, acted differently according to the tast used. It provoked sedation in spontaneous activity test, and anti-immobility effects in the other tests.
3. Tall suspension test is able to show the double acting of clonidine.
4. Idazoxan might act either as an alpha 2 antagonist or as partial alpha 2 agonist. TST shown the unexpected partial alpha agonist effect of the molecule.
5. Forced swimming test is more specific for predicting antidepressant activity than tail suspension test which is close to a spontaneous activity model. 相似文献
3.
K. Bak 《Scandinavian journal of medicine & science in sports》1996,6(3):132-144
Competitive swimming is one of the most demanding and time-consuming sports. Swimmers at elite level practice 20–30 h per week. During 1 year's practice, the average top level swimmer performs more than 500,000 stroke revolutions per arm. These innumerable repetitions over many years of hard training together with an increasing muscular imbalance around the shoulder girdle seem to be the main etiological factors in the development of the overuse syndrome swimmer's shoulder. Shoulder pain in swimmers has in general been regarded as synonymous with coracoacromial impingement, i.e. anterior shoulder pain due to rotator cuff tendinitis, but new knowledge suggests that a concomitant glenohumeral instability plays an additional role. The diagnostic complexity of the problem is as challenging as the search for the gold standard of treatment. The condition should ideally be diagnosed as early as possible, and intensive functional rehabilitation of the shoulder girdle including the scapular muscles should be started in order to restore muscle balance. The surgical possibilities include subacromial decompression in cases of purely mechanical impingement. If a painful glenohumeral instability persists after intensive functional rehabilitation, anterior capsulolabral reconstruction can be performed. Still, however, short- and long-term results show that surgery is less successful in elite athletes involved in overhead sports. Prevention protocols include education of coaches in primary injury prophylaxis and the institution of resistance strength training in prepubescent swimmers. Emphasis should be made to improve muscular balance around the glenohumeral and scapulothoracic joints. 相似文献
4.
Active behaviors in the rat forced swimming test differentially produced by serotonergic and noradrenergic antidepressants 总被引:16,自引:0,他引:16
This study demonstrated that distinct patterns of active behaviors are produced by antidepressants that selectively inhibit norepinephrine (NE) or serotonin (5-HT) uptake in the rat forced swimming test (FST). A behavior sampling technique was developed to score the active behaviors swimming, climbing and diving, as well as immobility. The rat's behavior was recorded at the end of each 5-s period during the test session. The sampling technique was both reliable, as demonstrated by test-retest reliability and inter-rater reliability, and valid, as shown by comparison to the timing of behavior durations. Five different antidepressant drugs which block monoamine uptake and two 5-HT1A receptor agonists were shown to decrease immobility in the FST; however, they produced distinct patterns of active behaviors. The selective NE uptake inhibitors desipramine and maprotiline selectively increased climbing, whereas the selective serotonin reuptake inhibitors (SSRIs) fluoxetine, sertraline and paroxetine selectively increased swimming. The 5-HT1A receptor agonists 8-OH-DPAT and gepirone also selectively increased swimming. These results show that:1) SSRIs are not false negatives in the FST; 2) at least two behaviorally distinct processes occur in the FST; and 3) enhancement of NE neurotransmission may mediate climbing in the FST, whereas enhancement of 5-HT neurotransmission may mediate swimming. 相似文献
5.
6.
大白鼠游泳输出功测定仪的研制和疲劳方程Y=A+B/T的建立 总被引:1,自引:0,他引:1
研制了可以直接连续测量大鼠游泳输出功率的仪器,建立了一个理想的动物模型,通过分析对功率曲线进行函数拟合,得出了代表疲劳发生、作功能力下降的双曲线方程,通过分析衰竭时间和功、功率等参数的关系提出了衰竭阈概念。 相似文献
7.
目的 探讨力竭游泳对大鼠胃肠道 5 HT免疫反应细胞 (5 HTIR细胞 )的影响。方法 本研究以力竭游泳大鼠为运动模型 ,游泳后即刻取大鼠胃窦、十二指肠、空肠和回肠用免疫组织化学SP法检测 5 HT ,用图像分析系统测定胃肠 5 HTIR细胞数和平均灰度。结果 (1)游泳后胃窦 5 HTIR细胞数虽与对照组无明显差异 ,但阳性细胞的平均灰度却明显下降 (P <0 .0 5)。 (2 )十二指肠、空肠、回肠 5 HTIR细胞数都明显下降 ,与对照组相比有显著性差异 (P <0 .0 5) ,但只有空肠 5 HTIR细胞平均灰度明显增加 ,与对照组间有明显差异 (P <0 .0 5)。结果 胃肠道不同区域 5 HTIR细胞以不同的反应方式应答运动应激。 相似文献
8.
M. N. Sawka Ph.D. R. G. Knowlton D. S. Miles J. B. Critz 《European journal of applied physiology》1979,41(2):93-99
Summary The purpose of this investigation was to quantitate post-competition lactate (LA) concentrations of swimmers during a competitive collegiate meet. Blood LA was measured by an enzymatic method on 23 subjects 5 min after each race event. The largest mean LA concentration of 25.7 mM/L was observed in swimmers after competing in the 200-yd individual medley. Swimmers in the 200-yd butterfly, back, breast and freestyle races had similar mean blood LA concentrations (ranging from 16.4 to 20.6 mM/L). Swimmers in the two longest events, the 500-yd and 1,000-yd free style races, had mean LA concentrations of 15.6 and 10.0 mM/L, respectively. To account for the effects of motivation, LA concentrations were measured following maximal effort noncompetitive 100 and 200-yd swims. LA concentrations were slightly greater in conjunction with faster performances for the competitive as compared to the noncompetitive 100 and 200-yd swims. 相似文献
9.
The multipolar somata of dorsolateral commissural (dlc) interneurons (Roberts and Clarke, 1982) lie in a superficial dorsolateral position in the spinal cord of Xenopus laevis embryos. By applying horseradish peroxidase to one-half of the 100 microm diameter spinal cord, these neurons have been backfilled. Their dendritic branching pattern, commissural axonal projection and distribution near the time of hatching is described. Using Lucifer yellow-filled microelectrodes a population of sensory interneurons with dlc morphology has been identified. They have multipolar somata in a dorsolateral superficial position, obliquely projecting dendrites and a ventral commissural axon. They receive presumed monosynaptic excitation in response to electrical stimulation of sensory neurites in the skin on the same side as the soma. During fictive swimming activity in curarized embryos the dlc interneurons are rhythmically inhibited in time with ventral root discharge on the same side. Dlc interneurons can fire multiple impulses and can turn on fictive swimming when stimulated by intracellular current injection. Skin stimulation is followed by excitatory postsynaptic potentials (EPSPs) in contralateral ventral rhythmic neurons. These EPSPs are reduced by the application of NMDA receptor antagonist. We conclude that dlc interneurons are excited by primary skin afferent Rohon - Beard neurons, carry sensory information across the spinal cord to excite neurons on the opposite side by release of an excitatory amino acid transmitter and participate in reflexes and in the initiation of swimming. 相似文献
10.
Harro J Pähkla R Modiri A-R Harro M Kask A Oreland L 《Journal of neural transmission (Vienna, Austria : 1996)》1999,106(7-8):619-629
Summary. DSP-4 is a neurotoxin highly selective for the noradrenergic nerve terminals originating from the locus coeruleus. Preliminary
data suggested that its effect in a typical screening test for antidepressant drugs, the forced swimming test, is biphasic
dependent on the dose. In the present study, DSP-4 was administered in four doses (5, 10, 30 and 50 mg/kg) to male Wistar
rats. Administration of the neurotoxin had a dose-dependent biphasic effect on immobility time in the forced swimming test
8 and 9 days later. Thus, DSP-4 at the dose of 10 mg/kg increased immobility, but higher doses reduced this measure. The reduction
of noradrenaline concentration in the frontal cortex and hippocampus was dose-dependent starting from the dose 10 mg/kg. Cortical
β-adrenoceptor binding was increased by DSP-4 treatment at the doses 30 mg/kg and 50 mg/kg. These results suggest that the
increase in immobility time in the forced swimming test is associated with presynaptic changes in noradrenaline availability,
whereas the decrease in immobility observed after more complete denervation is associated with postsynaptic receptor supersensitivity.
Received September 2, 1998; accepted February 2, 1999 相似文献