基于三层结构的医疗综合信息查询系统设计与实现

三层结构是二层客户／服务器结构的发展，代表着应用程序的发展方向。文章比较了二层客户／服务器结构与三层结构的优缺点，并用三层结构技术设计实现了一个医疗综合信息查询系统。     

浅谈网站建设中的一些细节问题

结合“作业管理系统”实例,阐述了网站建设中细节上常见的技术问题,引出这些问题涉及的基本概念及给出适用的处理方法,并做出相应的结论。     

Automatic Identification of Web-Based Risk Markers for Health Events

Background

The escalating cost of global health care is driving the development of new technologies to identify early indicators of an individual’s risk of disease. Traditionally, epidemiologists have identified such risk factors using medical databases and lengthy clinical studies but these are often limited in size and cost and can fail to take full account of diseases where there are social stigmas or to identify transient acute risk factors.

Objective

Here we report that Web search engine queries coupled with information on Wikipedia access patterns can be used to infer health events associated with an individual user and automatically generate Web-based risk markers for some of the common medical conditions worldwide, from cardiovascular disease to sexually transmitted infections and mental health conditions, as well as pregnancy.

Methods

Using anonymized datasets, we present methods to first distinguish individuals likely to have experienced specific health events, and classify them into distinct categories. We then use the self-controlled case series method to find the incidence of health events in risk periods directly following a user’s search for a query category, and compare to the incidence during other periods for the same individuals.

Results

Searches for pet stores were risk markers for allergy. We also identified some possible new risk markers; for example: searching for fast food and theme restaurants was associated with a transient increase in risk of myocardial infarction, suggesting this exposure goes beyond a long-term risk factor but may also act as an acute trigger of myocardial infarction. Dating and adult content websites were risk markers for sexually transmitted infections, such as human immunodeficiency virus (HIV).

Conclusions

Web-based methods provide a powerful, low-cost approach to automatically identify risk factors, and support more timely and personalized public health efforts to bring human and economic benefits.     

Discovery of Cellular RhoA Functions by the Integrated Application of Gene Set Enrichment Analysis

The small GTPase RhoA has been studied extensively for its role in actin dynamics. In this study, multiple bioinformatics tools were applied cooperatively to the microarray dataset {"type":"entrez-geo","attrs":{"text":"GSE64714","term_id":"64714"}}GSE64714 to explore previously unidentified functions of RhoA. Comparative gene expression analysis revealed 545 differentially expressed genes in RhoA-null cells versus controls. Gene set enrichment analysis (GSEA) was conducted with three gene set collections: (1) the hallmark, (2) the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway, and (3) the Gene Ontology Biological Process. GSEA results showed that RhoA is related strongly to diverse pathways: cell cycle/growth, DNA repair, metabolism, keratinization, response to fungus, and vesicular transport. These functions were verified by heatmap analysis, KEGG pathway diagramming, and direct acyclic graphing. The use of multiple gene set collections restricted the leakage of information extracted. However, gene sets from individual collections are heterogenous in gene element composition, number, and the contextual meaning embraced in names. Indeed, there was a limit to deriving functions with high accuracy and reliability simply from gene set names. The comparison of multiple gene set collections showed that although the gene sets had similar names, the gene elements were extremely heterogeneous. Thus, the type of collection chosen and the analytical context influence the interpretation of GSEA results. Nonetheless, the analyses of multiple collections made it possible to derive robust and consistent function identifications. This study confirmed several well-described roles of RhoA and revealed less explored functions, suggesting future research directions.     

如何有效发挥医院信息查询系统的作用

医院信息查询系统是HIS的重要组成部分。医院信息查询系统在功能上应满足管理层的需要；在操作上应尽量方使快捷；在设计上应讲究表达方式。使信息查询系统在医院管理中有效地发挥作用。     

基于安全数据交换的HIS综合查询系统设计

目的:为了解决医院数据安全和数据共享之间的矛盾,使患者能够实时地通过多媒体查询平台获得就医体检数据和诊断报告。方法:采用先进的安全数据交换技术达到网络隔离的效果,综合查询系统在硬件架构上采用嵌入式系统,软件使用精简的嵌入式Linux操作系统。结果:通过系统的内网查询模块、外网查询模块和安全数据交换模块的设计,实现了医院信息系统综合查询平台的系统设计。结论:通过在HIS综合查询系统测试平台中的应用,有效地证明了该系统设计方案的可行性、可靠性和实用性。     

继承验证质疑创新——关于中医药现代化发展的思考

通过对中医药现代科学研究历史的回顾,认为２１世纪中医药的现代化发展,不单纯是技术问题,主要是指导思想、思维方法和观念的问题。强调在中医药现代研究思维方法中应自觉地应用整体观念作为指导思想;应从传统开始,走出传统,取其数理化弃其糟粕,在与现代科学技术相互融合的发展过程中,历经继承、验证、质疑创新四个阶段,进行中医药学新的理论综合。     

Behavioral and social sciences theories and models: are they used in unintentional injury prevention research?

Behavioral and social sciences theories and models have the potential to enhance efforts to reduce unintentional injuries. The authors reviewed the published literature on behavioral and social science theory applications to unintentional injury problems to enumerate and categorize the ways different theories and models are used in injury prevention research. The authors conducted a systematic review to evaluate the published literature from 1980 to 2001 on behavioral and social science theory applications to unintentional injury prevention and control. Electronic database searches in PubMed and PsycINFO identified articles that combined behavioral and social sciences theories and models and injury causes. The authors identified some articles that examined behavioral and social science theories and models and unintentional injury topics, but found that several important theories have never been applied to unintentional injury prevention. Among the articles identified, the PRECEDE PROCEED Model was cited most frequently, followed by the Theory of Reasoned Action/Theory of Planned Behavior and Health Belief Model. When behavioral and social sciences theories and models were applied to unintentional injury topics, they were most frequently used to guide program design, implementation or develop evaluation measures; few examples of theory testing were found. Results suggest that the use of behavioral and social sciences theories and models in unintentional injury prevention research is only marginally represented in the mainstream, peer-reviewed literature. Both the fields of injury prevention and behavioral and social sciences could benefit from greater collaborative research to enhance behavioral approaches to injury control.     

探讨设备科引进设备维修信息管理系统

技术的革新带动了医院信息化建设的发展,医院医疗设备管理信息化也在逐渐的改进,能够大大提高工作效率,同时也方便信息的共享和查询、方便管理。     

医院多媒体触摸屏查询系统的开发与应用

本文针对南京军区南京总医院的实际情况，开发了基于多媒体触摸屏查询方式的导医系统，并详细介绍了导医系统的设计原则、软硬件开发环境及主要功能。