Determination of residual Kryptofix 2.2.2 levels in [F]-labeled radiopharmaceuticals for human use

4,7,13,16,21,24-Hexaoxa-1,10-diazabicyclo[8.8.8]hexacosane (Kryptofix^® 2.2.2) is used in the routine preparation of [¹⁸F]-labeled tracers employed in positron emission tomography (PET) imaging. Confirming the absence of Kryptofix^® in radiopharmaceuticals is a quality control criterion required before they can be released for human use. Analysis of Kryptofix^® levels using the iodoplatinate spot-test can be complicated by false-positive results due to nitrogen containing tracers and/or false-negative results caused by added stabilizers. To overcome this issue, we have developed a universal TLC method for the rapid and reliable determination of Kryptofix^® levels in the wide range of fluorine-18 radiopharmaceuticals we prepare, including complex multi-component formulations.     

Drug-Resistant Tuberculosis in Pet Ring-Tailed Lemur,Madagascar

We diagnosed tuberculosis in an illegally wild-captured pet ring-tailed lemur manifesting lethargy, anorexia, and cervical lymphadenopathy. Whole-genome sequencing confirmed the Mycobacterium tuberculosis isolate belonged to lineage 3 and harbored streptomycin resistance. We recommend reverse zoonosis prevention and determination of whether lemurs are able to maintain M. tuberculosis infection.     

Pet in the therapy room: An attachment perspective on Animal-Assisted Therapy

John Bowlby's (1973 Bowlby, J. 1973. Attachment and loss: Vol. 2. Separation: Anxiety and anger, New York, NY: Basic Books. [Crossref] , [Google Scholar], 1980 Bowlby, J. 1980. Attachment and loss: Vol. 3. Sadness and depression, New York, NY: Basic Books.  [Google Scholar], 1982 Bowlby, J. 1982. Attachment and loss: Vol. 1. Attachment, New York, NY: Basic Books. Original work published 1969 [Google Scholar]) attachment theory is one of the most influential theories in personality and developmental psychology and provides insights into adjustment and psychopathology across the lifespan. The theory is also helpful in defining the target of change in psychotherapy, understanding the processes by which change occurs, and conceptualizing cases and planning treatment (Daniel, 2006 Daniel, S. I.F. 2006. Adult attachment patterns and individual psychotherapy: A review. Clinical Psychology Review, 26: 968–984. [Crossref], [PubMed], [Web of Science ®] , [Google Scholar]; Obegi & Berant, 2008 Obegi, J. H. and Berant, E. 2008. Attachment theory and research in clinical work with adults, New York, NY: Guilford Press.  [Google Scholar]; Sable, 2004 Sable, P. 2004. Attachment, ethology, and adult psychotherapy. Attachment & Human Development, 6: 3–19. [Taylor & Francis Online], [Web of Science ®] , [Google Scholar]; Wallin, 2007 Wallin, D. J. 2007. Attachment in psychotherapy, New York, NY: Guilford Publications.  [Google Scholar]). Here, we propose a model of Animal-Assisted Therapy (AAT) based on attachment theory and on the unique characteristics of human–pet relationships. The model includes clients' unmet attachment needs, individual differences in attachment insecurity, coping, and responsiveness to therapy. It also suggests ways to foster the development of more adaptive patterns of attachment and healthier modes of relating to others.     

Support for bereaved owners of pets

TOPIC: The bond that exists between people and their pets and its impact on physical and mental health. PURPOSE: To review the current literature and explore the clinical implications of bereavement related to pets. SOURCES: A comprehensive review of the bereavement, veterinarian, and agricultural literature related to attitudes and response patterns to pet and animal death. CONCLUSIONS: The death or loss of a beloved pet can be a life-changing event.     

Allergen avoidance does not alter airborne cat allergen levels in classrooms

BACKGROUND: Some schools in Sweden offer allergen avoidance classrooms for allergic children with severe asthma. However, the measures commonly used to achieve a reduction in allergen levels have not been properly evaluated. The aim of the present prospective study was to study whether the levels of airborne cat allergen are altered after introducing feasible intervention measures in classrooms, without interfering with peoples' freedom of choice regarding pet ownership. METHODS: Twenty-five classes, including five established allergy prevention classrooms participated in the study during a school year. After one term, six classes underwent a number of intervention measures recommended by the Swedish National Institute of Public Health. Curtains, upholstery and plants were removed, bookshelves were replaced with cupboards and regular cleaning was increased. Airborne dust was collected weekly (32 weeks) using duplicate Petri dishes (n = 1574) and on six occasions using two personal air samplers in each class (n = 264). RESULTS: Airborne cat allergen levels were showing a similar variability throughout the whole study in all classes. Despite extensive measures in order to reduce allergen exposure, cat allergen levels were unaltered in the six classes after intervention. Allergen levels were not significantly lower in the established allergy prevention classes, compared with the other classes. Cat allergen levels differed, however, significantly between classes with few and many cat owners (P < 0.05). CONCLUSIONS: We conclude that the recommended allergen avoidance measures used in this study did not reduce airborne cat allergen. It seems plausible that measures that fail to reduce allergen levels also fail to influence health status in allergic children but this remains to be shown.     

Factors Associated with Furry Pet Ownership Among Patients with Asthma

Background. Exposure to indoor allergens is an established risk factor for poor asthma control. Current guidelines recommend removing pets from the home of patients with asthma. Objectives. This cross-sectional study was conducted to determine the prevalence of furry pet ownership in asthmatics compared to nonasthmatics and to identify factors associated with furry pet ownership among those with asthma. Secondary analysis assessed characteristics among asthmatics that might be associated with allowing a furry pet into the bedroom. Methods. Using data from The National Asthma Survey collected from 2003 to 2004, we carried out univariate and multiple regression analyses, in 2009, to identify independent predictors of furry pet ownership in asthma sufferers after controlling for potential confounders. Results. Overall, asthmatics were more likely to own a furry pet than nonasthmatic individuals in the general population (49.9% versus 44.8%, p < .001). Multivariate analysis showed that female sex, older age, white race, and high income were independent predictors of furry pet ownership among asthmatics. Additionally, 68.7% of patients with asthma who own a furry pet allowed them into their bedroom. Higher income and carrying out ≤2 environmental control practices in the home were associated with increased likelihood of allowing a furry pet into the bedroom. Conclusions. Furry pet ownership is equally or more common among asthmatics compared to those without asthma. The majority of asthmatics with furry pets allow them into the bedroom. Recognizing and addressing these problems may help decrease asthma morbidity.     

Dog‐assisted therapy for older people with dementia: A review

This review summarises and critiques the published literature regarding dog therapy for older people with dementia living in residential aged care facilities. Nine studies were identified for inclusion and although the methodological variability of studies makes it difficult to draw firm conclusions, research suggests that dog therapy is beneficial for people with dementia. The most frequently reported findings were an increase in social behaviour and a decrease in agitated behaviour during dog contact. Improvement in social behaviour was found to be unrelated to the severity of dementia. Various improvements on measures of global function were also reported. No study adopted a randomised controlled trial design and a number of potentially important factors were not controlled for, including halo effects of animals on caregivers that may bias caregivers’ responses when acting as proxies for their relatives or residents. The premorbid relationship with dogs may be an important variable influencing outcomes.