全文获取类型
收费全文 | 72649篇 |
免费 | 8516篇 |
国内免费 | 2054篇 |
专业分类
耳鼻咽喉 | 626篇 |
儿科学 | 658篇 |
妇产科学 | 817篇 |
基础医学 | 7881篇 |
口腔科学 | 2316篇 |
临床医学 | 11204篇 |
内科学 | 8248篇 |
皮肤病学 | 679篇 |
神经病学 | 4367篇 |
特种医学 | 2489篇 |
外国民族医学 | 6篇 |
外科学 | 7397篇 |
综合类 | 10534篇 |
现状与发展 | 5篇 |
一般理论 | 8篇 |
预防医学 | 11143篇 |
眼科学 | 983篇 |
药学 | 6949篇 |
144篇 | |
中国医学 | 3230篇 |
肿瘤学 | 3535篇 |
出版年
2024年 | 357篇 |
2023年 | 1761篇 |
2022年 | 2807篇 |
2021年 | 3933篇 |
2020年 | 3614篇 |
2019年 | 3216篇 |
2018年 | 3051篇 |
2017年 | 3155篇 |
2016年 | 2852篇 |
2015年 | 3134篇 |
2014年 | 4809篇 |
2013年 | 5525篇 |
2012年 | 4168篇 |
2011年 | 4708篇 |
2010年 | 3735篇 |
2009年 | 3845篇 |
2008年 | 3732篇 |
2007年 | 3649篇 |
2006年 | 3112篇 |
2005年 | 2788篇 |
2004年 | 2209篇 |
2003年 | 1961篇 |
2002年 | 1517篇 |
2001年 | 1310篇 |
2000年 | 1172篇 |
1999年 | 1004篇 |
1998年 | 798篇 |
1997年 | 699篇 |
1996年 | 598篇 |
1995年 | 532篇 |
1994年 | 489篇 |
1993年 | 413篇 |
1992年 | 368篇 |
1991年 | 279篇 |
1990年 | 277篇 |
1989年 | 219篇 |
1988年 | 199篇 |
1987年 | 191篇 |
1986年 | 132篇 |
1985年 | 173篇 |
1984年 | 139篇 |
1983年 | 85篇 |
1982年 | 104篇 |
1981年 | 87篇 |
1980年 | 73篇 |
1979年 | 58篇 |
1978年 | 43篇 |
1977年 | 35篇 |
1976年 | 36篇 |
1974年 | 22篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
2.
3.
In clinical and epidemiological studies, there is a growing interest in studying the heterogeneity among patients based on longitudinal characteristics to identify subtypes of the study population. Compared to clustering a single longitudinal marker, simultaneously clustering multiple longitudinal markers allow additional information to be incorporated into the clustering process, which reveals co-existing longitudinal patterns and generates deeper biological insight. In the current study, we propose a Bayesian consensus clustering (BCC) model for multivariate longitudinal data. Instead of arriving at a single overall clustering, the proposed model allows each marker to follow marker-specific local clustering and these local clusterings are aggregated to find a global (consensus) clustering. To estimate the posterior distribution of model parameters, a Gibbs sampling algorithm is proposed. We apply our proposed model to the primary biliary cirrhosis study to identify patient subtypes that may be associated with their prognosis. We also perform simulation studies to compare the clustering performance between the proposed model and existing models under several scenarios. The results demonstrate that the proposed BCC model serves as a useful tool for clustering multivariate longitudinal data. 相似文献
4.
Collagens are the most abundant proteins in the extracellular matrix. They provide a framework to build organs and tissues and give structural support to make them resistant to mechanical load and forces. Several intra‐ and extracellular modifications are needed to make functional collagen molecules, intracellular post‐translational modifications of proline and lysine residues having key roles in this. In this article, we provide a review on the enzymes responsible for the proline and lysine modifications, that is collagen prolyl 4‐hydroxylases, 3‐hydroxylases and lysyl hydroxylases, and discuss their biological functions and involvement in diseases. 相似文献
5.
6.
深化家庭医生签约服务是深化医药卫生体制改革、强化基层医疗卫生服务、实现"健康中国"战略目标的重要选择,也是当前更好维护人民群众健康的重要途径。为有效推进签约服务工作,国家陆续推出各项政策,全国各地也在积极进行实践探索,成效明显。但是,签约服务仍面临诸多问题,其中"执行难"是签约服务深度推进的一大困境。通过史密斯政策执行过程模型,结合签约服务政策执行过程,发现签约服务仍存在法治性不足、政策执行人员水平不高、激励不足、政策环境影响等诸多制约因素。因此,需要从法律和制度方面进行顶层设计、提升执行人员素质和职业认同、建立医患互信、优化政策执行环境等角度进行政策创新,探索家庭医生签约服务可持续发展的路径。 相似文献
7.
《Molecular therapy》2022,30(8):2856-2867
- Download : Download high-res image (173KB)
- Download : Download full-size image
8.
9.
采用文献复习和实证研究经验的方法对《医疗质量管理办法》中涉及的医疗质量概念及相关问题进行探讨。《医疗质量管理办法》中的医疗质量的定义存在重大缺失,没有涉及医疗服务的结果,特别是患者安全。医疗质量的定义应与国际相关权威机构保持一致,应高度重视医疗服务的结果,特别是患者安全。 相似文献
10.
Raymond J. Chan RN PhD Vivienne E. Milch MBBS MHPol Fiona Crawford-Williams PhD Oluwaseyifunmi Andi Agbejule BRadTherapy Ria Joseph MNutrDiet Jolyn Johal BND Narayanee Dick BSc Matthew P. Wallen PhD Julie Ratcliffe PhD Anupriya Agarwal MBBS Larissa Nekhlyudov MD Matthew Tieu PhD Manaf Al-Momani BPharm Scott Turnbull PhD Rahul Sathiaraj MPH Dorothy Keefe MBBS MD Nicolas H. Hart PhD 《CA: a cancer journal for clinicians》2023,73(6):565-589
Patient navigation is a strategy for overcoming barriers to reduce disparities and to improve access and outcomes. The aim of this umbrella review was to identify, critically appraise, synthesize, and present the best available evidence to inform policy and planning regarding patient navigation across the cancer continuum. Systematic reviews examining navigation in cancer care were identified in the Cochrane Central Register of Controlled Trials (CENTRAL), PubMed, Embase, Cumulative Index of Nursing and Allied Health (CINAHL), Epistemonikos, and Prospective Register of Systematic Reviews (PROSPERO) databases and in the gray literature from January 1, 2012, to April 19, 2022. Data were screened, extracted, and appraised independently by two authors. The JBI Critical Appraisal Checklist for Systematic Review and Research Syntheses was used for quality appraisal. Emerging literature up to May 25, 2022, was also explored to capture primary research published beyond the coverage of included systematic reviews. Of the 2062 unique records identified, 61 systematic reviews were included. Fifty-four reviews were quantitative or mixed-methods reviews, reporting on the effectiveness of cancer patient navigation, including 12 reviews reporting costs or cost-effectiveness outcomes. Seven qualitative reviews explored navigation needs, barriers, and experiences. In addition, 53 primary studies published since 2021 were included. Patient navigation is effective in improving participation in cancer screening and reducing the time from screening to diagnosis and from diagnosis to treatment initiation. Emerging evidence suggests that patient navigation improves quality of life and patient satisfaction with care in the survivorship phase and reduces hospital readmission in the active treatment and survivorship care phases. Palliative care data were extremely limited. Economic evaluations from the United States suggest the potential cost-effectiveness of navigation in screening programs. 相似文献