Risk factors for total ankle arthroplasty failure: A Dutch Arthroplasty Register study

BackgroundStudies concerning total ankle arthroplasty could be influenced by several forms of bias. Independent national arthroplasty registries represent objective data on survival and patient reported outcomes. The aim of this study was to determine survival and identify risk factors for early failure in a nationwide series of total ankle arthroplasties from the Dutch Arthroplasty Register (LROI).Patients and methodsData of 810 patients, who received 836 total ankle arthroplasties between 2014 and 2020 were obtained from the Dutch Arthroplasty Register (LROI) with a median follow-up of 38 months (range 1–84 months). Survival was expressed in Kaplan-Meier analysis and associated hazard ratios for implant failure were determined. Implant failure was defined as the need for revision surgery for any reason or (pan)arthrodesis.ResultsDuring follow-up, we recorded 39 failures (4.7%) resulting in a implant survival of 95.3% with a median follow-up of 38 months (range 1–84 months). Medial malleolus osteotomy (HR = 2.27), previous surgery (HR = 1.83), previous osteotomy (HR = 2.82) and previous ligament reconstruction (HR = 2.83) all showed potentially clinically meaningful associations with a higher incidence of implant failure, yet only previous OCD treatment (HR = 6.21), BMI (HR = 1.09) and age (HR = 0.71) were statistically significant.InterpretationExcellent short-term survival (95.3%) with a median follow-up of 38 months was reported for TAA patients from the Dutch Arthroplasty Register. Patients with a lower age, a higher BMI or who had a prior surgical OCD treatment before TAA surgery appear to have a higher risk for revision after short-term clinical follow-up. Thorough patient selection with emphasis on risk factors associated with early implant failure might be essential to improve TAA survivorship.     

Allopeptide-Specific CD4+ T Cells Facilitate the Differentiation of Directly Alloreactive Graft-Infiltrating CD8+ T Cells

To investigate the mechanism of CD4(+) T-cell help during the activation and differentiation of directly alloreactive CD8(+) T cells, we examined the development of obliterative airways disease (OAD) following transplantation of airways into fully mismatched recipient mice deficient in CD4(+) T cells. BALB/c trachea allografts became fibrosed significantly less frequently in B6 CD4(-/-) recipients as compared to wildtype controls. Furthermore, class I-directed cytotoxicity failed to develop in the absence of CD4(+) T cells. The infiltration of graft tissue by primed L(d)-specific directly alloreactive 2C CD8(+) T cells was not found to depend on the presence of CD4(+) T cells. Nevertheless, graft-infiltrating 2C CD8(+) T cells failed to express CD69 and granzyme B when CD4(+) T-cell help was unavailable. Importantly, reconstitution of B6 CD4(-/-) recipient mice with graft peptide-specific TCR-Tg CD4(+) T cells (OT-II or TEa) capable of recognizing antigen only on recipient APC allowed for full expression of CD69 and granzyme B by the directly alloreactive CD8(+) T cells and restored the capacity of recipients to reject their allografts. These results demonstrate that indirectly alloreactive CD4(+) T cells ensure the optimal activation and differentiation of graft-infiltrating directly alloreactive CD8(+) T cells independent of donor APC recognition.     

Victim Help Seeking: Differences Between Intimate Terrorism and Situational Couple Violence

Abstract: Research indicates that two major forms of partner violence exist, intimate terrorism (IT) and situational couple violence (SCV). The current study (N= 389) used a subgroup of women who responded to the Chicago Women’s Health Risk Study to examine whether type of violence experienced is differentially related to formal (e.g., police, medical agencies, counseling) and informal (e.g., family, friends/neighbors) help seeking. IT victims were more likely to seek each type of formal help but were equally or less likely to seek informal help. Findings can inform both family violence research and the development and implementation of social service programs.     

白内障扶贫复明手术探讨

目的：探讨山区白内障扶贫复明手术。方法：采用改良现代白内障囊外摘出术或小切口非超声乳化白内障摘除术，对2675只眼白内障施行复明手术。结果：术后第一天矫正视力0．3者57只眼(2．13％)，0．5～0．8者1829只眼(68．37％)，≥0．9者509只眼(19．03％)。角膜水肿71只眼(2.65％)，后囊膜破裂致玻璃体脱出87只眼(3．25％)，全部均可同时植入人工晶体。结论：采用改良的白内障摘除手术，做到开源节流，既能使更多的贫困患者接受复明手术，又保证了手术质量。     

Factors associated with quality of life in Menière's disease

The aim of this study was to identify the factors associated with better or worse quality of life in a sample of people with Menière's disease drawn from a UK self‐help group (the Menière's Society) and to assess the forms of support on which the respondents could draw. A postal survey was sent to 1000 randomly selected group members, containing validated questionnaires assessing: (1) quality of life (the Short Form 36 (SF‐36)); (2) factors that might predict quality of life; and (3) usage of resources provided to members by the Menière's Society. A total of 509 members completed the main survey, and 370 the second part of the survey. Factors associated with a less good quality of life included more severe vertigo, pressure in the ear, hearing loss and tinnitus, being younger, being female, living alone, having a lower occupational status and believing that the attitude of the consultant is unhelpful. Levels of vertigo severity in this sample were similar to those found in hospital samples, but it is possible that these respondents may differ in other respects from patients who do not join a self‐help group.     

人肿瘤细胞TH2类细胞因子的逆转与NK抗性变化的研究

目的研究促使人肿瘤细胞中ＴＨ２类细胞因子表达向ＴＨ０型的逆转及逆转后的肿瘤细胞对ＮＫ抗性的变化。方法首先用ＭＴＴ方法对悬浮培养的肿瘤细胞株ＤＢ大淋巴细胞瘤、Ｋａｒｐａｓ淋巴瘤、Ｍｉｃｈａｅｌ淋巴瘤、Ｒａｊｉ、ＨＬ６０和Ｋ５６２进行了ＮＫ杀伤敏感性的筛选。选择ＮＫ不敏感的Ｋａｒｐａｓ淋巴瘤和ＨＬ６０，用ｒｈＩＦＮγ、ｒｈＩＬ－１２和抗ＩＬ－１０ＭｃＡｂ经不同组合对其进行由ＴＨ２类细胞因子表达向ＴＨ１类细胞因子表达的促逆转研究，并观察促逆转后的肿瘤细胞对ＮＫ抗性的变化。结果ＲＴ－ＰＣＲ结果表明，经上述不同细胞因子组合诱导后，Ｋａｒｐａｓ淋巴瘤细胞均从表达ＴＨ２类细胞因子为主向ＴＨ０型逆转，并且各组逆转后的肿瘤细胞对ＮＫ的抗性均有不同程度的减弱。结论ＴＨ１类细胞因子（如ＩＦＮγ）、ＴＨ２类细胞因子拮抗剂（如ＩＬ－１０单抗）和ＩＬ－１２不同程度地促进肿瘤细胞表达的细胞因子由ＴＨ２型向ＴＨ０／ＴＨ１型逆转。促逆转后可以改善肿瘤细胞对机体杀伤作用的敏感性，提高抗肿瘤免疫能力     

大学生寻求专业心理帮助态度测量工具的初步研究

目的在综合有关研究文献的观点，以开放问卷调查为基础上，编制适合中国大学生寻求专业心理帮助量表，为研究大学生心理求助提供测评工具。方法从大学生心理求助行为实际出发，对大学生进行开放式问卷调查，随机抽取有代表性的福建省的大学生样本．对问卷作因素分析和效度与信度分析。结果提出信任、需求、容忍度和开放度共4个维度构成大学生寻求专业心理帮助态度的结构和成分；编制的“大学生寻求专业心理帮助态度量表”总量表信度系数为0．8392。结论大学生寻求专业心理帮助态度量表具有良好的信度和效度，可在实际中应用。     

Electronic data processing in the Danish Cytogenetic Central Register and EDP problems of registers in general

A brief introduction to the Danish Cytogenetic Central Register (DCCR) is given, and possibilities, principles and problems concerning the establishment and maintenance of a national cytogenetic register are presented.
Various data carrier media for registers in general are discussed, of which the magnetic disc is considered most appropriate. General principles for programs capable of performing insertions, deletions and other modifications in the data base are outlined as well as the principles for the programs in the DCCR.
The individual records should preferably be identified by aid of a central person registration number (CPR) rather than by name. The data should be stored and sorted by this identification in order to facilitate retrieval of a desired record. The structure of the records is discussed with regard to prevention of the occurrence of certain errors as well as the optimization of processing.
Flexibility and economy of space are achieved by using programs able to handle records of unequal length, and problems occurring in connection with this are discussed. The question of how to protect sensitive data is dealt with, and two different methods used in the DCCR are outlined. Programs capable of analyzing karyotypes with the purpose of recognizing various cytogenetic syndromes have been developed for use in the DCCR. Various examples of computing times of typical program runs are presented.     

大学生寻求专业性心理帮助态度的预测因素研究

目的:探讨大学生寻求专业性心理帮助态度的预测因素。方法:选取700名不同年级、不同专业的大学生作样本,进行问卷调查。结果:以寻求专业性心理帮助态度为因变量,进行性别(2)×专业(2)的方差分析。结果发现,性别的主效应显著,F(1,615)=3.294,P=0.050。专业的主效应显著,F(1,615)=20.896,P=0.001。性别和专业的交互效应没达到显著性水平,F(1,615)=1.890,P=0.170。以寻求专业性心理帮助态度为因变量,回归分析结果得出R=0.636,R2=0.405,F=29.641,P=0.001,说明建立的回归方程是有意义的。结论:①对寻求专业性心理帮助态度有显著预测作用的变量按预测作用大小排序依次是:是否求助过、依赖的自我结构、自我隐藏度、专业、内控性和性别。②女生的寻求专业性心理帮助的态度比男生积极。③文体艺术类学生的寻求专业性心理帮助的态度比非文体艺术类学生积极。④自我结构是相互依赖的人寻求专业性心理帮助的态度积极。⑤自我隐藏度高的人寻求专业性心理帮助的态度消极。⑥内控者寻求专业性心理帮助的态度消极。