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排序方式: 共有130条查询结果,搜索用时 15 毫秒
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Yvonne P.J. Bosch Raed Al DieriHugo ten Cate Patty J. NelemansSaartje Bloemen Bas de LaatCoenraad Hemker Patrick W. WeerwindJos G. Maessen Baheramsjah Mochtar 《Thrombosis research》2014
Introduction
Patients undergoing cardiac surgery with cardiopulmonary bypass (CPB) are susceptible to haemostatic disturbances. Monitoring the haemostatic capacity by conventional clotting tests is challenging.Materials and Methods
Thrombin generation (TG) by Calibrated Automated Thrombography, clotting tests and tissue factor pathway inhibitor (TFPI) measurements were performed to describe the relationship between haemostatic changes and alterations in these tests. Blood samples were collected before, during and after CPB. Furthermore, it was investigated whether TG measured intraoperatively, is associated with increased risk of bleeding postoperatively.Results
TG diminished significantly (p < 0.01) after heparinization in the presence and absence of platelets (37% and 50%) compared to baseline. After the start of CPB, TG elevated and persisted till the end of surgery but remained lower than preoperatively. Activated clotting time increased after heparinization and after the start of bypass compared to baseline (400% and 500%). Anti-FXa activity reduced on the start of CPB compared to the level after heparinization, to almost the baseline value following protamine reversal of heparin. The plasma levels of total and free TFPI elevated 9 and 14 fold during bypass and remained after protamine administration higher than preoperatively. Plasma D-dimer levels reduced (p < 0.01) when bypass started. However, a marked elevation was observed in the following time points. TG in platelet-rich plasma measured after heparinization and after the start of CPB associated (p < 0.05) with postoperative blood loss.Conclusions
TG can be determined during CPB despite the high heparinization level, it reflects the haemostatic capacity better than clotting-based assays and might better predict bleeding when performed intraoperatively. 相似文献5.
John E. Campbell Kevin W. Kuntz Sarah K. Knutson Natalie M. Warholic Heike Keilhack Tim J. Wigle Alejandra Raimondi Christine R. Klaus Nathalie Rioux Akira Yokoi Satoshi Kawano Yukinori Minoshima Hyeong-Wook Choi Margaret PorterScott Nigel J. Waters Jesse J. Smith Richard Chesworth Mikel P. Moyer RobertA. Copeland 《ACS medicinal chemistry letters》2015,6(5):491-495
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Subgingival bacterial clusters and serum antibody response as markers of extent and severity of periodontitis in adult Chinese
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Gunnar Dahlén Wen‐Min Luan Ulf Dahlgren Panos P. Papapanou Vibeke Baelum Ole Fejerskov 《European journal of oral sciences》2016,124(2):179-187
This study evaluated the associations between clinical, microbiological, and antibody activity manifestations of periodontitis in 123 adult rural Chinese subjects with no dental intervention. All participants were registered for full‐mouth clinical attachment level (CAL) and pocket probing depth (PD) measurements, and microbial samples were taken from four sites and analyzed for 18 different bacterial species using the ‘checkerboard’. Serum from each individual was analyzed to determine the antibody activity against the same 18 species. Exploratory factor analysis disclosed two microbial factors – Factor 1, consisting of seven species associated with periodontal health (‘early colonizers’); and Factor 2, consisting of eight species associated with periodontitis (‘putative periodontopathogens’) – which explained 87% of the variation among the microbial variables. Factor 2 was consistently associated with disease‐severity measures, whereas the ‘early colonizer’ factor was not. The antibody response showed weak or no correlations with bacterial load or with disease severity. We conclude that the bacteria investigated are resident in the subgingival plaque; that their load and proportions in the pocket may be ecologically driven; and that the antibody response is based on bacterial carrier state rather than on disease. The different antibody‐response pattern found between the individuals may suggest that each individual could be classified as a good or a weak immune responder. 相似文献
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在法制化管理的轨道上开展药品监督管理工作 总被引:2,自引:0,他引:2
通过认真学习、宣传、贯彻《药品管理法》,达到保证药品质量,保障人民用药安全有效的目的。 相似文献
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我国城镇医疗保障制度的进程、问题及对策 总被引:1,自引:1,他引:1
我国城镇医疗保障制度历经50多年的历史,为保障广大人民群众的身体健康做出了巨大的贡献.其进程大致可划分为3个阶段。但是,从制度发展的过程来看,既有成功的方面,也出现不少漏洞,现阶段城镇医疗保障制度的问题依然突出.需要从各个方面去解决,以更好地推动城镇医疗保障制度的不断完善。 相似文献
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榆林市榆阳区2 828名3~7岁儿童龋齿患病情况的调查分析 总被引:2,自引:0,他引:2
目的调查与分析儿童龋齿患病率发病因素对儿童健康的危害性。方法对榆阳区2828名3~7岁儿童进行逐一检查.患龋齿病儿童有1252例,患病率为44.3%。结论龋齿患病率高,对儿童健康危害极大,必须采取切合实际的有效预防和治疗措施,降低儿童龋齿患病率,提高儿童健康水平。 相似文献
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