Prevalence and predictors associated with severe pulmonary hypertension in COPD

Background

Pulmonary hypertension (PH) is one of the most common complications of COPD (chronic obstructive pulmonary disease), but its severe form is uncommon. Various factors play an important role in the occurrence and severity of pulmonary hypertension in patients.

高血压和合并动脉粥样硬化患者血小板分布宽度、血糖血脂水平变化及其危险因素分析

目的:回顾性比较高血压和合并动脉粥样硬化(AS)患者中血小板、血糖、血脂、血尿酸等指标的水平变化,分析高血压及合并AS的危险因子.方法:选取2019-06—2019-08在本院体检人群资料,按照检查结论分为高血压组(n=44)、高血压+AS组(n=73)和非高血压及AS对照组(n=91),采用临床检验科常规方法分别检测...     

小儿急性阑尾炎患者血小板参数检测的临床意义

目的通过分析小儿急性阑尾炎患者血小板各项参数的变化情况,探讨血小板指标在该疾病诊断中的临床意义,为该疾病的诊断提供更多实验室依据。方法选择52例急性阑尾炎患儿及49例健康对照者,采用Sysmex2100全自动血液分析仪检测血小板参数,包括血小板计数（plateletcount,PLT）、平均血小板体积（meanplateletvolume,MPV）、血小板分布宽度（plateletdistributionwidth,PDW）及外周血细胞计数。采用SPSS17．0软件对检测结果及各参数间相关性进行统计学分析。结果与对照组相比,阑尾炎患者组WBC及PLT明显升高,而MPV和PDW降低,差异均具有统计学意义（P均〈0．01）。相关性分析结果显示MPV与PDW（r=0．974,P〈0．01）,以及PLT与WBC（r=0．451,P〈0．01）均呈正相关关系,PLT分别与MPV和PDW（r=-0．610,r=-0．621,P均〈0．01）,WBC分别与PDW和MPV（r=-0．335,r=-0．364,P均〈0．05）均呈负相关。结论急性阑尾炎患儿外周血存在PLT增高、而MPV和PDW降低的血小板模式,用这些参数联合其他炎性指标建立诊断模型可能对小儿急性阑尾炎具有较大的实验室诊断价值。     

多功能超声心动图对178例先天性心脏病的诊断分析

经手术证实的178例先天性心脏病都经过2DE检查,诊断阳性率90.5%(161/178);其中85例经PDW检查,阳性率为94.2%(80/85);178例中有31例用CDFI检查,阳性率为96.8%(30/31)。2DE、PDW和CDFI的漏诊或部分漏诊率分别为9.5%、5.8%和3.2%。     

Platelet distribution width and the extent of coronary artery disease: Results from a large prospective study

It has been postulated that large platelets may be an indicator of platelet activation, and thus be related to the extent of coronary artery disease (CAD). Platelet distribution width (PDW) directly measures the variability in platelet size. However, no data has been so far reported on this index and CAD. Thus, the aim of the current study was to investigate whether PDW is associated with the extent of CAD. We measured PDW in 1882 consecutive patients undergoing coronary angiography. Significant CAD was defined as stenosis >50% in at least one coronary vessel. We additionally measured Carotid Intima-Media Thickness (IMT) in 359 patients. Patients with higher PDW were older (p = 0.012), with higher weight (p < 0.0001) and waist (p < 0.0001), larger prevalence of diabetes (p = 0.014), dilated cardiomyopathy or valvular heart disease (p < 0.0001) and less often family history of CAD (p = 0.021), more often on statins (p = 0.005), and diuretics (p = 0.016). PDW was significantly associated with baseline glycaemia (p = 0.002) and Red Blood Cell count (p < 0.0001), but inversely related to platelet count (p < 0.0001). PDW was not associated with the prevalence of coronary artery disease (OR [95% CI] = 0.91 [0.81–1.04], p = 0.16; adjusted OR [95% CI] = 0.96 [0.82–1.12], p = 0.56). No relationship was observed between IMT and PDW as tertiles or as continuous variable (Mean IMT: r = 0.04; p = 0.46; Maximal IMT: r = 0.036, p = 0.49). This study showed that PDW is not related to the extent of CAD and carotid IMT. Thus, PDW can not be considered as a risk factor for CAD.     

Laboratory preparation and evaluation of a multiparameter hemocytometry control

A protocol for the laboratory preparation of a multiparameter hemocytometry control is given. Human platelets, stabilized by a basically simplified and inexpensive fixation procedure, are added to our previously described white and red blood cell control. Evaluation of this multiparameter control shows good precision characteristics and acceptable mechanical stability for at least 7 weeks, as measured in the Coulter counter Model S Plus-II. The control can basically contribute to the realization of the essence of internal quality control: continuous self-auditing and continuous attempts at improvement of performance.     

白血病患者治疗前后血小板四项参数检测的价值

白血病患者平均血小板体积、血小板体积分布宽度、血小板计数、血小板压积在化疗前后不同时期的特点各有不同,可间接反映骨髓的代偿及恢复情况,对白血病治疗及预后有一定的诊断价值.     

MPV PDW 对血小板计数结果准确性判断的作用

目的：通过血小板MPV PDW分析血球分析仪对血小板计数结果的准确性.方法：血液分析仪测定血小板数量,当MPV PDW异常时做手工显微镜计数.结果：MPV PDW异常时（主要是增大时）仪器计数血小板与人工计数存在差异.结论：仪器计数血小板时,要结合MPV PDW 及血小板直方图判断其准确性,必要时做手工计数.     

Prognostic value of selected platelet parameters of patients operated for non-small cell lung cancer

BackgroundPlatelets play a vital role in the neoplastic process. Platelet parameters are hence an important source of information concerning ongoing neoplastic disease. The aim of the study is to assess the impact of selected platelet parameters on the survival of patients with non-small cell lung cancer (NSCLC).MethodsThe study included 532 (174 female and 358 male) patients aged 36–84 years (mean age 63.6 years) operated on due to NSCLC, staged IA–IIIA. Before the operation, all patients received a blood morphology test. The following parameters were subjected to statistical analysis: platelet count, mean platelet volume (MPV) parameter, platelet distribution width (PDW) parameter, platelet-to-lymphocyte ratio (PLR) and systemic immune-inflammation (SII) index. These findings were compared with the clinical data of the patients, and the probability of overall survival was analyzed.ResultsThe univariate analysis revealed a correspondence between PDW, MPV, PLR and SII index and patient survival. The multivariate analysis including patient clinical data found the following factors to have negative prognostic value for patients operated on due to NSCLC: male sex, advancement stage of neoplastic disease and Charlson Comorbidity Index (CCI) above 4, and PLR >144.ConclusionsPDW value, PLR and SII index are independent prognostic factors. In the multi-factor model, male sex, the advancement stage of the neoplastic disease, CCI above 4 and PLR lower than 144 had the greatest prognostic value.