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危重症病人肾前性急性肾衰竭的临床及预后分析 总被引：1，自引：0，他引：1
目的 了解危重症病人入院时肾前性急性肾衰竭(PARF)的发生率、常见病因和诱因、影响转归和预后的相关因素。方法 对1998-08～2002-08中心收治的867例危重症病例进行回顾性总结分析。结果 100例病人存在PARF(发生率为11．53％)。最常见的病因和诱因为有效循环血容量减少、心力衰竭、脓毒症／脓毒性休克。81％的病例经有效治疗后肾功能恢复，19％病例肾功能恶化、进展为急性肾小管坏死(ATN)，共24例病人死亡。多因素Logistic回归分析显示，APACHE Ⅱ评分、肾脏低灌流持续时间和脓毒性休克与PARF恶化密切相关。PARF恶化、透析治疗、APACHE Ⅱ评分和脓毒性休克是PARF死亡的危险因素。结论 循环血容量减少、心力衰竭引起PARF及时治疗肾功能多可恢复，并有良好预后；脓毒症／脓毒症休克所致者PARF多进展为ATN，预后不良。 相似文献
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Jun Kanazawa Hironori Masuko Yohei Yatagai Tohru Sakamoto Hideyasu Yamada Haruna Kitazawa Hiroaki Iijima Takashi Naito Takefumi Saito Emiko Noguchi Tomomitsu Hirota Mayumi Tamari Nobuyuki Hizawa 《Allergology international》2019,68(1):77-81
Background
TYRO3 is a member of the TAM (TYRO3, AXL, MERTK) receptor tyrosine kinase family and functions to limit type 2 immune responses implicated in allergic sensitization. Recent studies have shown that multiple intronic variants of TYRO3 were associated with asthma, implying that genetic variation could contribute to errant immune activation. We therefore hypothesized that expression quantitative trait loci (eQTLs) of the TYRO3 gene influence the development of allergic diseases (including asthma and allergic rhinitis) in Japanese populations.Methods
We performed a candidate gene case–control association study of 8 eQTLs of TYRO3 on atopy, asthma, and allergic rhinitis using 1168 unrelated Japanese adults who had GWAS genotyping. We then examined the genetic impact of rs2297377 (TYRO3) on atopy and allergic rhinitis in 2 other independent Japanese populations.Results
A meta-analysis of 3 Japanese populations (a total of 2403 Japanese adults) revealed that rs2297377 was associated with atopy and allergic rhinitis (OR = 1.29 and 1.31; P = 0.00041 and 0.0010, respectively). The risk allele at rs2297377 correlated with decreased expression of TYRO3 mRNA. The gene–gene interaction between HLA-DPB1 and TYRO3 was not significant with regard to sensitization. The estimated proportion of atopy and allergic rhinitis cases attributable to the risk genotype was 14% and 16%, respectively.Conclusions
Our study identified TYRO3 as an important susceptibility gene to atopy and allergic rhinitis in Japanese. 相似文献4.
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