全文获取类型
收费全文 | 30003篇 |
免费 | 822篇 |
国内免费 | 245篇 |
专业分类
耳鼻咽喉 | 161篇 |
儿科学 | 1245篇 |
妇产科学 | 1195篇 |
基础医学 | 3548篇 |
口腔科学 | 282篇 |
临床医学 | 1399篇 |
内科学 | 8669篇 |
皮肤病学 | 484篇 |
神经病学 | 2332篇 |
特种医学 | 858篇 |
外国民族医学 | 1篇 |
外科学 | 4597篇 |
综合类 | 819篇 |
预防医学 | 1560篇 |
眼科学 | 458篇 |
药学 | 2026篇 |
2篇 | |
中国医学 | 379篇 |
肿瘤学 | 1055篇 |
出版年
2023年 | 307篇 |
2022年 | 581篇 |
2021年 | 638篇 |
2020年 | 505篇 |
2019年 | 2321篇 |
2018年 | 2307篇 |
2017年 | 897篇 |
2016年 | 329篇 |
2015年 | 383篇 |
2014年 | 958篇 |
2013年 | 837篇 |
2012年 | 822篇 |
2011年 | 818篇 |
2010年 | 551篇 |
2009年 | 533篇 |
2008年 | 567篇 |
2007年 | 542篇 |
2006年 | 475篇 |
2005年 | 517篇 |
2004年 | 454篇 |
2003年 | 403篇 |
2002年 | 261篇 |
2001年 | 226篇 |
2000年 | 164篇 |
1999年 | 190篇 |
1998年 | 139篇 |
1997年 | 164篇 |
1996年 | 135篇 |
1995年 | 128篇 |
1994年 | 136篇 |
1993年 | 121篇 |
1992年 | 99篇 |
1991年 | 119篇 |
1989年 | 101篇 |
1988年 | 97篇 |
1987年 | 103篇 |
1986年 | 98篇 |
1985年 | 1113篇 |
1984年 | 1867篇 |
1983年 | 1204篇 |
1982年 | 1296篇 |
1981年 | 1271篇 |
1980年 | 1057篇 |
1979年 | 938篇 |
1978年 | 860篇 |
1977年 | 730篇 |
1976年 | 826篇 |
1975年 | 580篇 |
1974年 | 529篇 |
1973年 | 585篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
《Archivos de bronconeumología》2022,58(1):11-21
BackgroundWe aimed to describe the effectiveness and safety of inhaled antibiotics in chronic obstructive pulmonary disease (COPD) patients, as well as the patient profile in which they are usually prescribed and the patient groups that can most benefit from this treatment.MethodsMulticentre retrospective observational cohort study in COPD patients who had received ≥1 dose of inhaled antibiotics in the last 5 years. Clinical data from the two years prior to and subsequent to the start of the treatment were compared. Primary outcome: COPD exacerbations. Secondary outcomes: side effects, symptomatology (sputum purulence, dyspnoea), microbiological profile and pathogen eradication.ResultsOf 693 COPD patients analyzed (aged 74.1; 86.3% men; mean FEV1 = 43.7%), 71.7% had bronchiectasis and 46.6% presented chronic bronchial infection (CBI) by Pseudomonas aeruginosa (PA). After 1 year of treatment with inhaled antibiotics, there was a significant decrease in the number of exacerbations (?33.3%; P < .001), hospital admissions (?33.3%; P < .001) and hospitalization days (?26.2%; P = .003). We found no difference in effectiveness between patients with or without associated bronchiectasis. Positive patient outcomes were more pronounced in PA-eradicated patients. We found a significant reduction in daily expectoration (?33.1%; P = .024), mucopurulent/purulent sputum (?53.9%; P < .001), isolation of any potentially pathogenic microorganisms (PPM) (?16.7%; P < .001), CBI by any PPM (?37.4%; P < .001) and CBI by PA (?49.8%; P < .001). CBI by any PPM and ≥three previous exacerbations were associated with a better treatment response. 25.4% of patients presented non-severe side-effects, the most frequent of these being bronchospasm (10.5%), dyspnoea (8.8%) and cough (1.7%).ConclusionsIn COPD patients with multiple exacerbations and/or CBI by any PPM (especially PA), inhaled antibiotics appear to be an effective and safe treatment, regardless of the presence of bronchiectasis. 相似文献
2.
3.
4.
5.
6.
Ahmed M. Abu El-Asrar Ajmal Ahmad Eef Allegaert Mohammad Mairaj Siddiquei Priscilla W. Gikandi Gert De Hertogh 《Ocular immunology and inflammation》2020,28(4):575-588
ABSTRACT
Purpose
To investigate the expression of IL-11 and its receptor IL-11Rα and to quantify density of CD163+ M2 macrophages in proliferative diabetic retinopathy (PDR). 相似文献7.
8.
《Gaceta sanitaria / S.E.S.P.A.S》2021,35(3):236-242
ObjectiveTo explore the views of the Internet in childhood, identifying both health assets and risks.MethodA qualitative study was performed using 14 focus groups, eight of which comprised boys and girls, four of which comprised parents and two of which were mixed (children and parents) in primary schools in urban and rural settings in Andalusia (Spain). Teachers in these schools were also asked to complete an online questionnaire using LimeSurvey. This study involved 114 individuals: 64 pupils (33 girls and 31 boys), 28 parents (18 mothers and 10 fathers), and 22 teachers (14 women and 8 men). Analysis of manifest content and underlying meanings was carried out. QSR NVivo 9 software was used to facilitate analysis and make it systematic.ResultsOur findings show how the differences in the way parents and children understand health and wellbeing affect the way they discuss the Internet and health. The discussion of results looks at the implications of computer literacy for public health and wellbeing, particularly with regard to health assets.ConclusionsParents and children understand the contribution of the Internet to health and wellbeing differently. Whilst parents emphasize the risks (unsafe environment, relationships and quality of information, social networks, physical problems and addiction), the children emphasize the assets offered by the Internet. 相似文献
9.
José Antonio Pereira Miguel Pera Manuel López-Cano Marta Pascual Sandra Alonso Silvia Salvans Marta Jiménez-Toscano Alba González-Martín Luis Grande-Posa 《Cirugía espa?ola》2019,97(1):20-26
Objectives
To determine the incidence of incisional hernia (IH) in the extraction incision (EI) in colorectal resection for cancer. To analyze whether the location of the incision has any relationship with the incidence of hernias and whether mesh could be useful for prevention in high-risk patients.Methods
Retrospective review of the colon and rectal surgery database from January 2015 to December 2016. Data were classified into 2 groups, transverse (TI) and midline incision (MI), and the latter was divided into 2 subgroups (mesh [MIM] and suture [MIS]). Patients were classified using the HERNIAscore. Hernias were diagnosed by clinical and/or CT examination.Results
A total of 182 out of 210 surgical patients were included. After a median follow-up of 13.0 months, 39 IH (21.9%) were detected, 23 of which (13.4%) were in the EI; their frequency was lower in the TI group (3.4%) and in the MIM group (5.9%) than in the MIS group (29.5%; p = 0.007). The probability of developing IH in the MIS group showed an OR = 11.7 (95%CI: 3.3-42.0) compared to the TI group and 4.3 (IC 95%: 1.1-16.3) versus the MIM group.Conclusions
The location of the incision is relevant to avoid incisional hernias. Transverse incisions should be used as the first option. When a midline incision is needed, a prophylactic mesh could be considered in high risk patients because it is safe and associated with low morbidity. 相似文献10.