中医药发展已上升到国家战略层面,在医药行业贯彻实施"中国制造2025"战略的新形势下,中药生产过程质量控制是中药工业需要加快突破的关键领域之一。对中药生产过程质量控制领域在工艺设计、分析检测、过程建模、制造装备等方面的关键共性问题进行解析,综述了中药生产过程质量控制体系中工艺过程理解、生产过程实时分析方法开发、过程控制策略建立3个方面的研究进展;并结合企业研究实践,介绍了质量源于设计(quality by design,Qb D)、过程分析技术(process analytical technology,PAT)、实验设计(design of experiment,DOE)、多变量统计分析等关键技术在上述3个研究方向中的应用进展,分析了实际工业应用的难点问题并对其应用前景进行展望,旨在为中药企业应用和提升生产过程质量控制技术提供参考。 相似文献
Objective: Keyes’ two continua model is a useful concept in which mental health and mental illness exist on two separate axes. Based on this model, this study examined the prevalence and correlates of three mental health categories among older adults in China.
Methods: Cross-sectional data were derived from Wave 1 of the Study on Global AGEing and Adult Health. Participants were categorized into complete mental health (CMH), complete mental illness (CMI), and moderate mental health (MMH) groups. Multinomial logistic regressions were used.
Results: The prevalence of CMH, CMI, and MMH in China was 18%, 16%, and 66%, respectively. Being female, unmarried, younger, and feeling unhealthy were more likely to result in placement in the CMI category. Employment, education, and cognitive function were identified as important protective factors of CMH. Age, income, urban or rural residence, and physical function difficulty were associated with all three categories.
Discussion: We demonstrated the utility of the two continua model in identifying mental health needs in Chinese contexts. The findings suggest that future policy reforms and clinical interventions should establish a more comprehensive mental health category as a screening tool nationwide. The promotion of social engagement could play an important role in treating mental illness and improving positive mental health. 相似文献
IntroductionFor many years, nutrition of the elderly is of a special attention. The food policies wants to value the regional initiatives that can be slowed down, and new techniques of adapted food are in development. Following a tracking of malnutrition in an establishment for dependent elderly, a program of nutritional improvement was set up. It was decided to transform the dishes of the daily menu into small enriched, mixed, prehensile mouthfuls, with for objective to use the remaining capacities of the patients, to adapt the care to their rhythm, to answer their expectations and their nutritional needs.MethodThe agents of texture of the mouthfuls were adapted. Their enrichment and their presentation were specified, as well as the modalities of distribution, in order to allow an easy access as well by the patients, the nursing and the families. Cooled cupboards were used.ResultsThe residents found again the pleasure to eat by themselves, their self-respect and consequently covered better their needs. A decrease of the malnutrition prevalence was observed. Times of exchange with other establishments and a formation were set up to share this tool. Levers were identified to develop this concept under good conditions.ConclusionThe adapted enriched mouthfuls tool seems to be useful. Its application is inseparable of a voluntary multidisciplinary approach, anchored in the knowledge of the accompanied person and in the analysis of her global situation. This tool is adaptable not only in any structure welcoming dependent, old people or not, but also at home. 相似文献