我国城镇医疗保障制度的进程、问题及对策

我国城镇医疗保障制度历经50多年的历史，为保障广大人民群众的身体健康做出了巨大的贡献．其进程大致可划分为3个阶段。但是，从制度发展的过程来看，既有成功的方面，也出现不少漏洞，现阶段城镇医疗保障制度的问题依然突出．需要从各个方面去解决，以更好地推动城镇医疗保障制度的不断完善。     

Prognostic value of microRNA-451 in various cancers: A meta-analysis

BackgroundIncreasing evidence shows microRNA-451 plays a crucial role in various tumors, but there is inconsistency. The aim of this study was to explore the prognostic role of miR-451 in various tumors.MethodsOnline PubMed, EMBASE, Web of Science, and the Cochrane library database were searched through February 2019. Hazard ratios (HRs) were extracted and used to describe the association between expression of microRNA-451 and survival outcome, and the correlation between microRNA-451 and clinicopathologic features were described by pooled odds ratios (ORs).ResultsSixteen retrospective studies containing 2122 patients were incorporated in this meta-analysis. High expression of miR-451 was considered statistically associated with prolonged overall survival (OS) (HR = 0.62, 95% CI 0.49-0.80, p < 0.001) as well as RFS/DFS (HR = 0.55, 95% CI 0.42-0.71, p < 0.001) compared with low expression of miR-451. Besides, the pooled ORs revealed significant association between high expression of miR-451 with lymph node invasion (yes vs. no) (OR = 0.64, 95% CI 0.46-0.90, P = 0.01), tumor diameter (big vs. small) (OR = 0.77, 95% CI 0.60-0.97, P = 0.028) and tumor stage (III + IV vs. I + II) (OR = 0.62, 95% CI 0.42-0.93, P = 0.019).ConclusionMicroRNA-451 may serve as a promising clinical prognostic biomarker in various carcinomas.