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1.
Azathioprine, a well-known immunosuppressive agent, is used extensively in renal transplantation. There have been several case reports of pure red cell aplasia induced by this drug following a successful kidney transplant. Previous management of azathioprine-induced red cell aplasia included reduction of azathioprine dose, or treatment with cyclophosphamide. We propose the substitution of cyclosporine for azathioprine, in this clinical setting. Not only does cyclosporine allow recovery of bone marrow function, but it maintains a level of immunosuppression which stabilizes renal function in the post-transplant patient. 相似文献
2.
带状疱疹患者红细胞免疫功能的测定 总被引:1,自引:1,他引:0
采用红细胞酵母菌花结试验检测了32例带状疱疹患者的红细胞免疫粘附活性。结果显示:疾病组红细胞C3b受体花环率(7.76±1.76%)较对照组(9.46±l.73%)明显降低(P<0.01),而红细胞免疫复合物花环率(9.92±1.99%)较对照组(4.71±2.28%)明显增高(P<0.01)。 相似文献
3.
John M. Opitz Gunnar B. Stickler James F. Reynolds 《American journal of medical genetics. Part A》1987,27(4):971-975
We report on a consanguineous Brazilian couple whose 2 children had tibial aplasia-ectrodactyly. Femoral bifurcation was present in one of the affected children. The relationship of tibial aplasia-ectrodactyly to the Gollop-Wolfgang complex is discussed. Clinical and genetic aspects of the conditions involving tibial aplasia and femoral bifurcation are discussed. 相似文献
4.
H.-D. Rott 《Clinical genetics》1984,26(1):36-38
Dermatoglyphic investigation of palm prints in patients with Incontinentia pigmenti revealed in five of eight cases a partial ridge dissociation with lack of sweat gland pores. This disease can, therefore, be accepted as a second X-linked anhidrotic ectodermal dysplasia, which, however, is only segregated in the female. 相似文献
5.
6.
Severe cytopenias associated with the sequential use of busulphan and interferon-alpha in chronic myeloid leukaemia 总被引:1,自引:0,他引:1
We describe four patients who developed severe thrombocytopenia which progressed to aplasia after the use of α-interferon in maintenance therapy of chronic phase CML after busulphan induction. On reviewing over 400 patients in the MRC CML III trial we found that there is a risk of cytopenia developing after busulphan therapy and a lesser risk of cytopenias developing after α-interferon therapy. If the therapies are given in a sequential fashion the risk of cytopenia developing appears to be additive, may be pronounced, and may lead to clinically significant problems. Hydroxyurea alone does not lead to sustained cytopenia. Care should be taken to ensure that counts are stable after the use of busulphan before starting α-interferon as maintenance therapy. 相似文献
7.
Y. L. Kwong K. F. Wong R. H. S. Liang Y. C. Chu L. C. Chan T. K. Chan 《Annals of hematology》1996,72(3):137-140
Pure red cell aplasia (PRCA) is a rare hematological disease characterized by selective marrow erythroid aplasia. We report
the clinical features and treatment results of 16 Chinese patients with PRCA. Nine (56%) cases were not associated with any
underlying disorders and were considered idiopathic, while seven patients (44%) had associated diseases, three involving the
thymus, two with T large granular lymphocyte leukemia (T-LGLL), and one each with Stevens-Johnson syndrome and acute hepatitis
A. Conventional-dose corticosteroid therapy resulted in complete remission in three of 13 patients. Cyclosporin A was used
in six patients. There were three complete and one partial remissions. High-dose methylprednisolone was ineffective in four
patients who failed conventional-dose corticosteroids but achieved complete remission in one patient with thymoma who did
not respond to thymectomy. Antithymocyte globulin was used in four patients, resulting in partial remission in only one patient
with concomitant T-LGLL. Intravenous gamma globulin and danazol were ineffective in three patients. Thymectomy was performed
in two patients, with one patient remitting. This is the largest series of PRCA reported in an oriental population. Our results
indicate that treatment of PRCA may still be problematic and better therapeutic strategy will have to be defined.
Received: 11 September 1995 / Accepted: 1 January 1996 相似文献
8.
目的探讨肾移植术后人类微小病毒(HPV)B19感染致纯红细胞再生障碍性贫血(纯红再障)的诊断和治疗特点。方法总结南方医科大学南方医院器官移植科收治的2例肾移植术后HPV B19感染致纯红再障的病例,结合文献复习讨论该病的临床特点、诊断方法、治疗过程及预后。结果两例肾移植受者术后早发严重贫血且进行性加重,输血治疗无效。排除导致贫血的其他原因,综合骨髓穿刺活检、荧光聚合酶链反应(PCR)检测HPV DNA等方法诊断为HPV B19感染致纯红再障。经调整免疫抑制方案、静脉注射用免疫球蛋白(IVIG)等治疗后2例患者贫血症状明显改善。结论对于肾移植术后早期不明原因、进行性加重的贫血患者,特别是伴随网织红细胞缺乏者,应考虑HPV B19感染致纯红再障的可能性。骨髓穿刺及荧光PCR检测结果是诊断纯红再障的主要依据,免疫抑制剂减量和应用IVIG治疗是主要治疗措施。经治疗后,患者预后较好,但易复发。 相似文献
9.
Multicentric Castleman's disease associated with renal amyloidosis and pure red cell aplasia 总被引:1,自引:0,他引:1
K. Hattori S. Irie Y. Isobe M. Wakiya T. Matsumoto K. Suda K. Funabiki Y. Tomino T. Hirano K. Oshimi 《Annals of hematology》1998,77(4):179-181
A 50-year-old man was admitted suffering from severe anemia and renal dysfunction. He had been admitted for the first time
at the age of 49, and was diagnosed with multicentric Castleman's disease (MCD) and secondary amyloidosis. At that time, marked
erythroid hypoplasia was demonstrated by both aspiration and biopsy of bone marrow. A diagnosis of pure red-cell aplasia (PRCA)
was made. Immunosuppressive agents improved his symptoms and laboratory data. We report here a very rare case of PRCA following
MCD and amyloidosis, and with reference to the literature, we discuss the relation between MCD and related diseases.
Received: February 12, 1998 / Accepted: June 17, 1998 相似文献
10.
Iuliana Badiu Davide Diena Giuseppe Guida Carlo Ferrando Davide Rapezzi Luca Besso 《Clinical Case Reports》2022,10(4)
We describe a case of concomitant erythropoietin allergy and resistance with a possible IgE and IgG‐mediated immune response, in which the local allergic cutaneous symptoms preceded the antibody‐mediated anemia. 相似文献