全文获取类型
收费全文 | 5948篇 |
免费 | 563篇 |
国内免费 | 591篇 |
专业分类
耳鼻咽喉 | 3篇 |
儿科学 | 7篇 |
妇产科学 | 5篇 |
基础医学 | 306篇 |
口腔科学 | 19篇 |
临床医学 | 240篇 |
内科学 | 538篇 |
皮肤病学 | 113篇 |
神经病学 | 19篇 |
特种医学 | 87篇 |
外科学 | 91篇 |
综合类 | 1213篇 |
预防医学 | 513篇 |
眼科学 | 10篇 |
药学 | 1340篇 |
1篇 | |
中国医学 | 2513篇 |
肿瘤学 | 84篇 |
出版年
2024年 | 29篇 |
2023年 | 167篇 |
2022年 | 213篇 |
2021年 | 294篇 |
2020年 | 166篇 |
2019年 | 148篇 |
2018年 | 124篇 |
2017年 | 198篇 |
2016年 | 198篇 |
2015年 | 233篇 |
2014年 | 371篇 |
2013年 | 513篇 |
2012年 | 378篇 |
2011年 | 372篇 |
2010年 | 324篇 |
2009年 | 319篇 |
2008年 | 290篇 |
2007年 | 264篇 |
2006年 | 338篇 |
2005年 | 339篇 |
2004年 | 305篇 |
2003年 | 258篇 |
2002年 | 154篇 |
2001年 | 169篇 |
2000年 | 129篇 |
1999年 | 80篇 |
1998年 | 71篇 |
1997年 | 98篇 |
1996年 | 57篇 |
1995年 | 83篇 |
1994年 | 74篇 |
1993年 | 45篇 |
1992年 | 39篇 |
1991年 | 32篇 |
1990年 | 43篇 |
1989年 | 43篇 |
1988年 | 29篇 |
1987年 | 32篇 |
1986年 | 16篇 |
1985年 | 23篇 |
1984年 | 15篇 |
1983年 | 8篇 |
1982年 | 4篇 |
1980年 | 3篇 |
1979年 | 3篇 |
1978年 | 2篇 |
1977年 | 3篇 |
1976年 | 3篇 |
1974年 | 1篇 |
1973年 | 1篇 |
排序方式: 共有7102条查询结果,搜索用时 31 毫秒
1.
《Saudi Pharmaceutical Journal》2022,30(11):1572-1588
Non-alcoholic fatty liver disease (NAFLD) is one of the most common complications of a metabolic syndrome caused by excessive accumulation of fat in the liver. Orthosiphon stamineus also known as Orthosiphon aristatus is a medicinal plant with possible potential beneficial effects on various metabolic disorders. This study aims to investigate the in vitro inhibitory effects of O. stamineus on hepatic fat accumulation and to further use the computational systems pharmacology approach to identify the pharmacokinetic properties of the bioactive compounds of O. stamineus and to predict their molecular mechanisms against NAFLD. Methods: The effects of an ethanolic extract of O. stamineus leaves on cytotoxicity, fat accumulation and antioxidant activity were assessed using HepG2 cells. The bioactive compounds of O. stamineus were identified using LC/MS and two bioinformatics databases, namely the Traditional Chinese Medicine Integrated Database (TCMID) and the Bioinformatics Analysis Tool for the Molecular Mechanism of Traditional Chinese Medicine (BATMAN-TCM). Pathway enrichment analysis was performed on the predicted targets of the bioactive compounds to provide a systematic overview of the molecular mechanism of action, while molecular docking was used to validate the predicted targets. Results: A total of 27 bioactive compounds corresponding to 50 potential NAFLD-related targets were identified. O. stamineus exerts its anti-NAFLD effects by modulating a variety of cellular processes, including oxidative stress, mitochondrial β-oxidation, inflammatory signalling pathways, insulin signalling, and fatty acid homeostasis pathways. O. stamineus is significantly targeting many oxidative stress regulators, including JNK, mammalian target of rapamycin (mTOR), NFKB1, PPAR, and AKT1. Molecular docking analysis confirmed the expected high affinity for the potential targets, while the in vitro assay indicates the ability of O. stamineus to inhibit hepatic fat accumulation. Conclusion: Using the computational systems pharmacology approach, the potentially beneficial effect of O. stamineus in NAFLD was indicated through the combination of multiple compounds, multiple targets, and multicellular components. 相似文献
2.
3.
4.
Stephen Hanessian 《ACS medicinal chemistry letters》2016,7(1):6-9
Current major advances in drug discovery
can be traced back to
pioneering contributions originating from academics over a century
ago. Living in a symbiotic yet noninvasive coexistence, the academic
community and the pharmaceutical industry have strived, each in their
own way, to develop the modern medicines that benefit humankind today.
The subject is presented from a historical and personal perspective. 相似文献
5.
A survey of plants used as wild vegetables was conducted in four districts of Botswana in August and September 2005. The objective was to determine which wild plants were used as vegetables in the study area, and to document their cooking and preservation methods. Fourteen species representing seven families were mentioned as wild vegetables. In addition, six species from four families had other uses in traditional medicine. The implications of the documented processing methods on the retention of nutrients in the vegetables are discussed. 相似文献
6.
7.
目的探讨中药当归、川芎、黄芪、丹参提取液对大鼠放射性骨髓损伤的防护作用.方法雄性SD大鼠60只,随机分为正常对照组、模型组、中药组,每组6只,在相同条件下饲养2周,模型组和中药组大鼠给予6.0 Gy 60Co γ射线一次性全身照射,继续饲养1周处死全部动物并取材.用骨髓细胞计数法计数骨髓有核细胞数,用Western blot法测定血管内皮生长因子(vascularendothelialgrowth factor,VEGF)、血小板衍生生长因子(ptatelet derived growth factor,PDGF)的蛋白含量.结果与正常对照组比较,模型组大鼠的骨髓有核细胞数、VEGF、PDGF蛋白含量明显减少(P<0.01),与模型组比较,中药组大鼠的骨髓有核细胞数、VEGF、PDGF蛋白含量明显增加(P<0.01或P<0.05).结论中药当归、黄芪、川芎、丹参对大鼠放射性骨髓损伤有一定防护作用. 相似文献
8.
9.
10.
介绍了蓬辣滩水电站泄洪闸门的状况、计算机监控系统改造方案的结构和特点及闸门定轮轴承的改造情况,通过上述改造,提高了泄洪设备运行的自动化水平,同时也为其他闸门工程提供参考。 相似文献