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排序方式: 共有182条查询结果,搜索用时 31 毫秒
1.
《Clinical neurophysiology》2021,132(12):3104-3115
ObjectiveWe aimed to establish an objective neurophysiological test protocol that can be used to assess the somatosensory nervous system.MethodsIn order to assess most fiber subtypes of the somatosensory nervous system, repetitive stimuli of seven different modalities (touch, vibration, pinprick, cold, contact heat, laser, and warmth) were synchronized with the electroencephalogram (EEG) and applied on the cheek and dorsum of the hand and dorsum of the foot in 21 healthy subjects and three polyneuropathy (PNP) patients. Latencies and amplitudes of the modalities were assessed and compared. Patients received quantitative sensory testing (QST) as reference.ResultsWe found reproducible evoked potentials recordings for touch, vibration, pinprick, contact-heat, and laser stimuli. The recording of warm-evoked potentials was challenging in young healthy subjects and not applicable in patients. Latencies were shortest within Aβ-fiber-mediated signals and longest within C-fibers. The test protocol detected function loss within the Aβ-fiber and Aδ-fiber-range in PNP patients. This function loss corresponded with QST findings.ConclusionIn this pilot study, we developed a neurophysiological test protocol that can specifically assess most of the somatosensory modalities. Despite technical challenges, initial patient data appear promising regarding a possible future clinical application.SignificanceEstablished and custom-made stimulators were combined to assess different fiber subtypes of the somatosensory nervous system using modality-specific evoked potentials. 相似文献
2.
《Journal of prosthodontic research》2019,63(3):354-360
PurposeTo investigated the effect of vibratory stimulus on masseter muscles during oral fine motor biting tasks.MethodsSixteen healthy individuals (age: 24.5 ± 2.4 years) participated in experiment I during which the participants were asked to “hold and split” half a roasted peanut placed on a force transducer with their front teeth. The participant performed ten series with ten trials of the “hold and split” behavioral task while vibratory stimulus was applied on the masseter muscle every alternate series. Further, fourteen participants participated (age: 25.2 ± 4.8 years) in experiment II during which they performed a series each of the behavioral task at baseline, an adjusted baseline without and with vibration as well as with and without visual feedback. Hold and split forces along with the variability of hold force and duration and force rate during the split were measured.ResultsThe results of the study showed an increase in the magnitude of the hold force (P = 0.002), force rate during the split (P < 0.001) and a significant decrease in the duration of split (P < 0.001) due to the vibratory stimulus. However, there was no significant effect of the vibratory stimulus on the variability of hold forces (P = 0.879) or mean split force (P = 0.683) during the “hold and split” behavioral task. The results of experiment II also showed an increase in hold force due to the vibratory stimulus (P < 0.001).ConclusionsVibratory stimulus to the masseter muscles impairs the oral force control during a standardized biting task and provide further insight into the sensorimotor regulation of the masticatory system. 相似文献
3.
The significance of somatosensory stimulations to the human foot in the control of postural reflexes 总被引:1,自引:0,他引:1
G. Wu Jin-Hsien Chiang 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》1997,114(1):163-169
The purpose of this study was to investigate the possible pathways in the somatosensory system that relate to the postural
reflexes in the leg muscles during a sudden, toes-up platform rotation. The inputs to the cutaneous mechanoreceptors in the
sole of the foot as well as to the joint receptors in the ankle joint were modulated by standing on different supporting surfaces
and by immobilizing the ankle joints; and three leg muscle responses (characterized by short latency, medium latency, and
long latency) to the platform movement were recorded in 15 healthy young subjects. It was found that: (1) the short latency
was not affected by the changes in either plantar pressure or ankle joint movement; (2) the medium latency was regulated by
the plantar pressures under the foot, as sensed by the cutaneous mechanoreceptors in the sole of the foot, and by the ankle
joint movement, as perceived by the joint receptors in the ankle joint; (3) the long latency was also related to the ankle
joint movement, but this relation seems to be modulated by the plantar pressures under the foot; and (4) both medium and long
latencies were well correlated with the time derivative of the pressure difference between the forefoot and the rear foot
regions (r=0.7), as well as with the static pressure in the antagonist foot region (r>0.6).
Received: 12 January 1996 / Accepted: 30 September 1996 相似文献
4.
B. N. Gupta 《Pflügers Archiv : European journal of physiology》1977,367(3):271-275
Summary In the attempt to explain the difference in discharge pattern of atrial endings, 131 endings were localized by punctate stimulation, 44 were type A, 77 type B and 10 of an intermediate type. All were located on the dorsal wall of the atria with none on the ventral wall or in the appendage. On the right side, 74% of type A were located in the atria and 63% of type B in or near the veins. On the left side, 67% of type A and 94% of type B were located in or near the veins. Thus, there appeared to be some difference in the location of type A and type B endings on the right side, but on the left side both types of endings were for the most part confined to the venous region. Further, on both right and left sides, these endings were present both in the central part of the atria and in or adjacent to veins. This leads to the suggestion that the difference in discharge patterns is not caused by the location but may be due to some other reasons, e. g. difference of arrangement in the atrial wall with respect to the contractile elements. 相似文献
5.
S. E. RICKSTEN T. YAO G. F. DI BONA P. THORN 《Acta physiologica (Oxford, England)》1981,112(2):161-167
Exaggerated natriuresis upon volume loading occurs in both human and animal hypertension and is mainly due to suppressed tubular reabsorption. To explore whether altered renal sympathetic activity contributes to this response, conscious male spontaneously hypertensive rats (SHR) were exposed to isotonic saline loading in comparison with normotensive male Wistar Kyoto rats (WKR). After a 60 min control hydropenic period, during which mean arterial pressure, heart rate, renal sympathetic nerve activity and urinary sodium excretion were followed, a 60 min period of intravenous volume expansion with isotonic saline (0.2 ml/minx 100 g b. w.) was started followed by a 60 min hydropenic recovery period. Already during the control period sodium excretion was significantly higher in SHR. During the volume load and subsequent recovery period a clearly exaggerated natriuresis occurred in SHR compared with WKR. Further, volume loading reduced renal sympathetic nerve activity in all animals, but significantly more in SHR. Moreover, volume loading reduced mean arterial pressure and heart rate in both groups. It is suggested that the accentuated reflex inhibition of renal sympathetic activity in SHR upon volume loading emanates from cardiac mechanoreceptors and partly explains the exaggerated natriuresis in SHR. This augmented ‘volume’ reflex response is probably due to reduced systemic venous compliance in SHR with a consequently increased central filling and cardiac receptor activation. 相似文献
6.
Stephen E. Rill Mark Hallett Lisa M. McShane 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》1997,113(1):33-47
A coordinated triggering task requiring use of kinesthetic information was employed to assess the timing of use of kinesthetic
information in normal subjects and patients with cerebellar dysfunction. Passive movements of varying velocity were imposed
in the flexor direction about the metacarpophalangeal joint of the right index finger. Subjects attempted to depress a switch
with their left thumb when the index finger moved, past a specified angle that was learned during a training session. The
velocities ranged from 10°/s to 88°/s in 2°/s increments. After 200 trials, subjects were then instructed instead to react
as quickly as possible (reaction-time task) to the onset of movement for an additional 200 trials. For the same movements,
the timing of onset of responses of muscle spindle afferents and cutaneous mechanoreceptors was determined by recording the
responses of these afferents using microneurography. For slow velocities, patients were able to perform similarly to normals
but at faster velocities patients triggered too late compared with normals. Patients required more time to use kinesthetic
information than did normal subjects. An estimate of kinesthetic processing was not longer in patients. The chief explanation
for the prolonged time required to use kinesthetic information in patients was that their reaction times were prolonged by
93 ms. In addition, the movement time was also prolonged, but this accounted for only 23 ms. Impaired motor performance in
tasks requiring the use of kinesthetic information in cerebellar patients can be explained largely by their prolonged reaction
times. Muscle spindle afferents responded on average much sooner than cutaneous mechanoreceptors. Because of the limited time
available to perfomr the kinesthetic triggering task, the role for cutaneous mechanoreceptors, to provide singals for on-line
coordination of movement appears limited compared with muscle spindle afferents. 相似文献
7.
Psychophysical studies in humans have demonstrated adaptation of the mechanoreceptive submodalities of flutter and vibration after prolonged presentation of a strong adapting, or conditioning, stimulus. In our studies we recorded from single neurons in cat primary somatosensory cortex, and followed a paradigm in which the response of a single unit was measured before and after the presentation of a strong conditioning stimulus. Our findings show no adaptive response in the 30 sec period immediately after cessation of the conditioning stimulus, and suggest that other parallel ascending pathways or somatosensory cortical areas other than SI account for these psychophysical observations. 相似文献
8.
Norman F. Capra PhD 《Dysphagia》1995,10(4):235-247
Sensory nerves that supply mechanoreceptors in the mucosal lining of the oral cavity, pharynx, and larynx provide the substrate for a variety of sensations. They are essential for the perception of complex or composite sensory experiences including oral kinesthesia and oral stereognosis. Relevant to the concerns of the oral health care delivery specialist they also contribute to initiation of reflexes and coordination and timing of patterned motor behaviors. The response of oral mechanoreceptors to natural stimuli is determined to a large degree by morphological factors such as the nature of the relationship between nerve ending and certain cellular specializations, their distribution in the mucosa, the diameter of their primary afferent nerve fibers, and the central distribution of these fibers in the brainstem. Because of morphological similarities to certain cutaneous mechanoreceptors, the mucosal lining may be considered as an internal continuation of the large receptor sheet for localization and detection of mechanical stimuli. In some regions of the oral, pharyngeal, and laryngeal mucosa, this analogy is appropriate whereas in others, existing data suggest a different role consistent with regionally specific demands (i.e., initiation of protective reflexes). 相似文献
9.
B. D. Grubb G. J. Birrell D. S. McQueen A. Iggo 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》1991,84(2):383-392
Summary The role of PGE2 in the sensitization of highthreshold tarsal joint mechanoreceptors (putative nociceptors) has been investigated in 11 arthritic and 16 normal rats. Injections of a low dose of Freund's complete adjuvant at multiple sites into the tissues surrounding the ankle joint induced a chronic unilateral monoarthritis in the injected limb. Measurements of both spontaneous activity and responses of tarsal joint mechanoreceptors to repeated graded mechanical stimuli were made. All of the mechanoreceptors examined had afferent fibres with conduction velocities in the C or A- range. Using this new model of joint inflammation we have shown that lysine acetylsalicylate reduces the mechanical sensitivity of these joint mechanoreceptors and reduces the spontaneous activity in afferent nerve fibres. Prostaglandin E2 is unable to restore either the spontaneous activity in the afferent axon or the mechanical sensitivity of tarsal joint mechanoreceptors after lysine acetylsalicylate in the arthritic rat. Similarly, PGE2 does not sensitize or excite tarsal joint mechanoreceptors in the normal rat. In the normal rat, however, PGE2 potentiates the excitatory action of bradykinin and enhances the sensitizing effect of bradykinin on the responses of joint mechanoreceptors to mechanical stimulation when both substances are injected simultaneously. These results indicate that PGE2 is not important in the sensitization of these joint mechanoreceptors in this model of chronic joint inflammation but that in other circumstances PGE2 may be able to contribute to a sensitization of joint mechanoreceptors by enhancing the action of bradykinin. 相似文献
10.
Khaled Al-Manei Nabeel Almotairy Kholod Khalil Al-Manei Abhishek Kumar Anastasios Grigoriadis 《Journal of endodontics》2021,47(2):226-233
IntroductionPeriodontal mechanoreceptors (PMRs) are refined neural receptors present in abundance at the root apex and have a pivotal role in oral fine motor control. This case-control study aimed to evaluate the oral fine motor control of teeth treated with endodontic microsurgery (EMS) in comparison with the control teeth using a standardized behavioral biting task.MethodsFourteen eligible participants performed 5 trials of an oral fine motor control task that involved holding and splitting half of a peanut positioned on a force transducer with their EMS treated tooth and its contralateral control incisor tooth (28 teeth in total). The outcome variables were the mean food holding force, intra- and intertrial variability of the holding force, food splitting force, splitting duration, and the frequency of the stepwise splitting phase. The data were analyzed with parametric and nonparametric tests.ResultsThe results showed no statistically significant differences in the holding force, inter- and intratrial variability of the holding force, splitting force, or splitting duration between the teeth treated with EMS and the control (P > .05). However, there was a significantly higher frequency of stepwise ramp increase during the splitting phase with EMS treated teeth compared with the control (48% and 37%, respectively; P < .05).ConclusionsEMS treated teeth showed similar force regulation and oral fine motor control as the contralateral control. The findings of this study suggest that EMS treatment does not perturb the sensory information of PMRs and maintains the force regulation and oral fine motor control of the teeth. 相似文献