全文获取类型
收费全文 | 3605篇 |
免费 | 183篇 |
国内免费 | 117篇 |
专业分类
耳鼻咽喉 | 24篇 |
儿科学 | 167篇 |
妇产科学 | 16篇 |
基础医学 | 111篇 |
口腔科学 | 2篇 |
临床医学 | 347篇 |
内科学 | 860篇 |
皮肤病学 | 2篇 |
神经病学 | 496篇 |
特种医学 | 366篇 |
外科学 | 853篇 |
综合类 | 402篇 |
预防医学 | 53篇 |
眼科学 | 52篇 |
药学 | 108篇 |
中国医学 | 8篇 |
肿瘤学 | 38篇 |
出版年
2024年 | 6篇 |
2023年 | 72篇 |
2022年 | 109篇 |
2021年 | 138篇 |
2020年 | 138篇 |
2019年 | 113篇 |
2018年 | 102篇 |
2017年 | 108篇 |
2016年 | 120篇 |
2015年 | 113篇 |
2014年 | 207篇 |
2013年 | 177篇 |
2012年 | 149篇 |
2011年 | 178篇 |
2010年 | 118篇 |
2009年 | 143篇 |
2008年 | 142篇 |
2007年 | 148篇 |
2006年 | 160篇 |
2005年 | 152篇 |
2004年 | 116篇 |
2003年 | 95篇 |
2002年 | 89篇 |
2001年 | 72篇 |
2000年 | 93篇 |
1999年 | 68篇 |
1998年 | 71篇 |
1997年 | 59篇 |
1996年 | 60篇 |
1995年 | 63篇 |
1994年 | 73篇 |
1993年 | 40篇 |
1992年 | 35篇 |
1991年 | 27篇 |
1990年 | 24篇 |
1989年 | 34篇 |
1988年 | 44篇 |
1987年 | 21篇 |
1986年 | 23篇 |
1985年 | 32篇 |
1984年 | 24篇 |
1983年 | 15篇 |
1982年 | 26篇 |
1981年 | 25篇 |
1980年 | 16篇 |
1979年 | 15篇 |
1978年 | 19篇 |
1977年 | 10篇 |
1974年 | 10篇 |
1973年 | 4篇 |
排序方式: 共有3905条查询结果,搜索用时 0 毫秒
1.
《Journal of vascular and interventional radiology : JVIR》2020,31(7):1069-1073
This report describes a technique for measuring lung shunt fraction (LSF) twice in a single session during planning arteriography for radioembolization using low and standard dose technetium-99m macroaggregated albumin (99mTc-MAA). A patient with a 16.0 cm hepatocellular carcinoma and LSF of 70% was treated with lenvatinib for 4 weeks. Planning arteriography with administration of 0.5 millicuries of 99mTc-MAA was then performed. Arterial access was maintained while the LSF was calculated, which was persistently elevated at 54%. Embolization of arteriovenous shunts was performed during the same session and 5.0 millicuries of 99mTc-MAA were administered. The repeat LSF was 29%. Successful radioembolization was subsequently performed. 相似文献
2.
3.
H. Inaba M.D. J. Sato H. Uchida M. Sakurada T. Ohwada T. Mizuguchi 《Acta anaesthesiologica Scandinavica》1988,32(5):374-378
Fluctuating PEEP (F-PEEP) is a newly developed PEEP in which end-expiratory pressure (EEP) is periodically changed within a certain range. In a dog model with unilateral lung injury induced by the introduction of hydrochloric acid, F-PEEP in which the EEP was periodically changed from 0.5 to 1.5 kPa at periods of 6 min, and conventional PEEP (C-PEEP) with an optimized EEP of 1.0 kPa, were each applied for 30 min. F-PEEP produced a significantly greater improvement of PaO2 and intrapulmonary shunt (QS/QT) than C-PEEP, and at the low EEP phase, the greatest improvement accompanied by an increased dynamic compliance and a large cardiac output was obtained. These results suggest that F-PEEP provides a useful mode of artificial ventilation for the treatment of unilateral lung injury. 相似文献
4.
José Ignacio Bilbao Mercedes Arias Jesús María Longo Pedro Luis Alejandre María Teresa Betés Arlette María Elizalde 《Cardiovascular and interventional radiology》1997,20(2):149-153
Percutaneous embolization of large portosystemic collaterals was performed in three patients following placement of a transjugular
intrahepatic portosystemic shunt in order to improve hepatopetal portal flow. Improved hepatic portal perfusion was achieved
in these cases, thereby theoretically reducing the risk of chronic hepatic encephalopathy. 相似文献
5.
本文报告一种新的改良式远端脾肾静脉分流术,即脾静脉与左肾静脉侧侧吻合、脾静脉远端结扎,再将胃冠状静脉结扎。作者经治7例,初步观察疗效较好,术后无死亡,无复发出血,无肝性脑病发生。本文对这种手术的步骤和优点进行了讨论和分析。 相似文献
6.
Dynamic aspects of expanding cava septi pellucidi et Vergae 总被引:2,自引:0,他引:2
Summary Two paediatric patients with expanding cysts of the cava Vergae et septi pellucidi are presented. In the first patient, consecutive CT scans showed agrowing cavum thought to be responsible for his dramatic increase in head circumference. In the other patient, the expanding cavum was discovered because a routine skull X-ray after minor head trauma revealed marked impressiones digitatae.Both patients were successfully treated with stereotactically placed internal shunts from the cysts via the lateral ventricle to the subarachnoid space. During this procedure, contrast medium was instilled, and the cysts were visualized on postoperative CT scans.Some dynamic aspects of such expanding cava are discussed. 相似文献
7.
D. A. MOFFAT 《Clinical otolaryngology》1994,19(3):261-266
One hundred endolymphatic mastoid shunt operations in 89 patients with classical Menière's disease were analysed. The disease was bilateral in 18 patients (20%). The patients were carefully pre-selected by a comprehensive protocol of audiovestibular and metabolic investigations. All patients had definite electrophysiological evidence of endolymphatic hydrops with an enhanced negative summating potential on transtympanic electrocochleography. The surgical results were analysed both by the original American Academy of Ophthalmology and Otolaryngology Guidelines (AAOO, 1972) and the more recent modifications of the American Academy of Otolaryngology, Head and Neck Surgery (AA-HNS, 1985). Control of the vertigo was achieved in 81% of the patients overall, in 88% of the patients with unilateral disease and in 63% of the patients with bilateral disease. A significant hearing improvement was obtained in 19% of patients, no change in 55% and hearing became worse in 26%. Tinnitus improved in 38% of patients, was unchanged in 52% and became worse in 10%. Disability was assessed and there was no disability in 44% of the patients post-operatively, some degree of disability in 48% but only 8% were severely disabled and unable to sustain gainful employment. 相似文献
8.
Oxidative breakdown of octanoic acid is maintained in patients with cirrhosis despite advanced disease 总被引:1,自引:0,他引:1
M. Van de Casteele A. Luypaerts † B. Geypens † J. Fevery Y. Ghoos† & F. Nevens 《Neurogastroenterology and motility》2003,15(2):113-120
As an octanoic acid 13CO2 breath test is frequently used to test gastric emptying of solid food, the purpose of the present study was to study whether oxidative breakdown of octanoic acid is affected by severe liver disease. The design of our study was twofold. First, cirrhotic patients (n = 82) of varying severity were compared with healthy controls (n = 17). Values of half-time, time point of maximal expiration and cumulative recovery of octanoic acid breath tests (OBT) were not significantly different between them. Secondly, cirrhotic patients (n = 10) were studied before placement of transjugular intrahepatic portosystemic shunt, 4-7 days later and 1-2 months later. Values of half-time, time point of maximal expiration and cumulative recovery of consecutive OBTs did not change significantly. The OBT may therefore be a suitable test in the future to detect delayed gastric emptying of solids in cirrhotic patients with reduced liver function and portal hypertension. 相似文献
9.
Benoit J. M. Pirotte Alphonse Lubansu Michael Bruneau Chakir Loqa Nathalie Van Cutsem Jacques Brotchi 《Child's nervous system》2007,23(11):1251-1261
Objective The objective of this study was to evaluate whether the rigid application of a sterile protocol for shunt placement was applicable
on a routine basis and allowed the reduction of shunt infections (SI) in children.
Materials and methods Since 2001, a rigid sterile protocol for shunt placement in children using neither antibiotic-impregnated catheters nor laminar
airflow was prospectively applied at Erasme Hospital, Brussels, Belgium. For assessing the protocol efficacy before continuation,
we preliminarily analyzed the results of the first 100 operated children (43 females, 57 males, 49 aged <12 months; 115 consecutive
shunt placement/revision procedures). All procedures were performed by the same senior surgeon, one assistant, one circulating
nurse, one anesthesiologist. The sterile protocol was rigidly imposed to these four staff members: uniformed surgical technique;
limited implant and skin edge manipulation; minimized human circulation in the room; scheduling surgery as first morning operation;
avoiding postoperative cerebrospinal fluid (CSF) leak; double gloving; procedures of less than 30-min duration; systemic antibiotics
prophylaxis. We analyzed separately: (1) children carrying an increased risk of SI (n = 38) due to preoperative external ventricular drainage, CSF leak, meningitis, glucocorticoids, chemotherapy; (2) children
aged <12 months; (3) procedures for shunt revision.
Results Errors in protocol application were recorded in 71/115 procedures. They were mainly done by non-surgical staff, decreased
with time and were medically justified in some young children. Surprisingly, no SI occurred (follow-up, 4 to 70 months). One
child developed an appendicitis with peritonitis (Streptococcus faecalis) after 6 months. No SI was found. After peritonitis was cured, shunt reinsertion was uneventful.
Conclusion These preliminary results suggest that a uniform and drastic sterile surgical technique for shunt placement: (1) can be rigidly
applied on a routine basis; (2) can lower the early SI rate below 1%; (3) might have a stronger impact to reduce SI than using
antibiotic-impregnated catheters and optimizing the operative environment such as using laminar airflow and reducing the non-surgical
staff. This last issue will be evaluated further in the present ongoing protocol. 相似文献
10.
J. Menzel O. Schober P. Reimer W. Domschke 《European journal of nuclear medicine and molecular imaging》1997,24(6):635-641
In patients with liver cirrhosis a transjugularly placed intrahepatic portocaval shunt (TIPS) is a non-surgical portosystemic device which aims to reduce portal venons pressure. In comparison with Doppler sonography, we evaluated in 28 patients the diagnostic impact of liver perfusion scintigraphy (with technetium-99m diethylene triamine penta-acetic acid) in the assessment of changes in the hepatic blood flow after TIPS shunting. The arterial and portal contributions to hepatic flow were calculated from the areas under the biphasic timeactivity curve. In the course of TIPS shunting, patency is threatened by reocclusion. Angiography is the gold standard for TIPS shunt reassessment. However, there is a need for a less invasive diagnostic procedure, such as scintigraphy or Doppler sonography, for the early detection of shunt insufficiency. Scintigraphy demonstrated that prior to TIPS shunting the portal venons contribution to hepatic perfusion was reduced to 29.2%, this reduction being due to portal hypertension. After TIPS placement a significant increase in portal venous perfusion was observed (38.2%;P<0.02). TIPS shunt occlusion was identified in patients by a significant reduction in the scintigraphically measured portal venons contribution to hepatic blood flow. Hepatic perfusion scintigraphy appears to be a valuable method to determine the immediate effect of TIPS on hepatic blood flow. Post-TIPS follow-up studies of hepatic haemodynamics by liver perfusion scintigraphy appear able to contribute to the detection of TIPS shunt occlusion before the clinical consequences of this complication have become apparent. 相似文献