196例男性不育症患者的细胞遗传学分析

目的：研究染色体异常与男性不育的关系。方法：用常规方法制备外周血淋巴细胞标本，并对196例男性不育患者进行染色体G显带核型分析，个别辅作C带分析。结果：检出异常核型73例，占全部被检者37．2％。其中性染色体异常69例，占全部被检者35．2％，占异常核型94．5％，嵌合体3例，占异常核型4．1％；常染色体异常4例，占全部被检者2．04％，占异常核型5．5％。结论：细胞遗传学分析对不育患者是一个重要的实验室诊断手段。     

连建伟论治妇科经验举隅

[目的]探讨连建伟教授诊治妇科杂病之经验。[方法]收集近年连建伟教授有关不孕,月经不调等妇科医案427例,并汇总其中有代表性医案,探讨连教授的诊治特色。[结果]连建伟教授运用四诊辨证加减组方,针对妇女虚、寒、瘀体质引起的不孕,月经不调等疾病,灵活诊治,扶正祛邪,达到满意的疗效。[结论]连建伟教授使用古代妇科方药可有效治疗现代妇科问题,具有较好的临床实践及教学意义。     

秦国政教授从瘀论治男性不育症经验

古今医家关于男性不育症病因病机论述颇多,其中以肾虚立论为主,从血瘀邪实论述的较少。秦国政教授根据现代男性不育症"肾虚夹湿热瘀毒"的发病特点,结合辨证、辨病对男性不育症从瘀论治,常能收到较好的临床疗效。     

Infertility, involuntary infecundity, and the seeking of medical advice in industrialized countries 1970-1992: a review of concepts, measurements and results

Several new methods of infertility treatment have been developed.There is therefore an increasing interest among physicians ingaining knowledge about the occurrence of infertility in orderto estimate the need for treatment. This article examines epidemiologicalstudies in industrialized countries 1970–1992 on the prevalencesof infertility, involuntary infecundity, and the seeking ofmedical advice for infertility. The studies are compared onthe basis of study design, definitions, methods of measurementand results. Comparison of the studies is difficult, as researchersuse different concepts and there is a large variation in thedelineation of the populations involved. The current prevalenceof infertility among women in the fertile age group varies from3.6 to 14.3%, the life-time prevalence varies from 12.5 to 32.6%,the prevalence of involuntary infecundity from 2.6 to 5.9%,and medical contact for infertility from 3.6 to 17%. It is probablethat these large differences in prevalences are mainly due todifferences in definitions and methods of measurement. We recommendthat future studies be carried out in representative populationgroups, and that only couples who have tried to have childrenshould be included in the estimated prevalences.     

妍婷颗粒对输卵管炎性不孕大鼠模型ICAM-1的影响

目的探讨中药妍婷颗粒对输卵管炎性不孕大鼠细胞间黏附分子-1(intercellular adhesion molecule,ICAM-1)的影响及其疗效与机理.方法用混合菌接种法制作输卵管炎性不孕大鼠模型,以妍婷颗粒进行治疗,分为灌肠和灌胃两组,治疗后用ELISA法检测血清中可溶性细胞间黏附分子-1(solubility intercellular adhesion molecul,sICAM-1)水平和用免疫组织化学方法检测大鼠ICAM-1蛋白表达.结果大鼠ICAM-1蛋白表达和血清中sICAM-1水平灌胃组与灌肠组均较模型组降低(P＜0.05或P＜0.01),且灌肠组较灌胃组亦低(P＜0.05).结论妍婷颗粒对大鼠ICAM-1蛋白表达和血清中sICAM-1水平有调节作用,从而对大鼠炎性不孕具有很好的治疗作用.     

抗心磷脂抗体与不孕不育关系的研究进展

从病理生理的基础研究，药物治疗的实验研究，临床治疗的观察研究等方面研究分析，探讨抗心磷脂抗体与不孕不育之间的关系，认为抗心磷脂抗体主要通过影响血小板等形成血栓影响胎盘血液循环，使胎盘发育不良，妊娠早期可引起流产，妊娠中晚期发生胚胎死亡，抗心磷脂抗体的存在可导致不孕。     

抗心磷脂抗体与不孕不育关系的研究进展

从病理生理的基础研究,药物治疗的实验研究,临床治疗的观察研究等方面研究分析,探讨抗心磷脂抗体与不孕不育之间的关系,认为抗心磷脂抗体主要通过影响血小板等形成血栓影响胎盘血液循环,使胎盘发育不良,妊娠早期可引起流产,妊娠中晚期发生胚胎死亡,抗心磷脂抗体的存在可导致不孕。     

Fertility in Norwegian testicular cancer patients

The intention was to explore the relationship between fertility and testicular cancer, including the possibly treatment-induced changes over time in the post-diagnostic fertility. Data are from the Norwegian Cancer Registry, The Norwegian Population Register and the Population Censuses. By estimating Poisson regression models, birth rates among testicular cancer patients were compared with those of other men who had the same age, parity and duration since previous birth. Poisson regression models were also estimated to check whether men's parity has an effect on the cancer incidence. Fertility rates among testicular cancer patients born after 1935 and treated before 1991 decreased by roughly 30% when compared with the normal population. The introduction of cisplatin chemotherapy and of nerve-sparing RPLND in the 1980s seems to have enabled more patients with non-seminoma to father a child after treatment, or at least shortened the time to conception. Moreover, the risk of being diagnosed with seminoma is reduced with increasing parity. This suggests that the relatively low fertility after diagnosis may be partly due to the continuing inherent influence of a sub- or infecundity that also had a bearing on the development of the disease.