全文获取类型
收费全文 | 1031篇 |
免费 | 83篇 |
国内免费 | 40篇 |
专业分类
耳鼻咽喉 | 5篇 |
儿科学 | 35篇 |
基础医学 | 354篇 |
口腔科学 | 32篇 |
临床医学 | 51篇 |
内科学 | 243篇 |
皮肤病学 | 59篇 |
神经病学 | 30篇 |
特种医学 | 2篇 |
外科学 | 51篇 |
综合类 | 124篇 |
预防医学 | 70篇 |
眼科学 | 10篇 |
药学 | 33篇 |
中国医学 | 2篇 |
肿瘤学 | 53篇 |
出版年
2024年 | 1篇 |
2023年 | 13篇 |
2022年 | 28篇 |
2021年 | 52篇 |
2020年 | 23篇 |
2019年 | 23篇 |
2018年 | 38篇 |
2017年 | 35篇 |
2016年 | 33篇 |
2015年 | 41篇 |
2014年 | 51篇 |
2013年 | 56篇 |
2012年 | 56篇 |
2011年 | 51篇 |
2010年 | 52篇 |
2009年 | 36篇 |
2008年 | 49篇 |
2007年 | 42篇 |
2006年 | 47篇 |
2005年 | 42篇 |
2004年 | 61篇 |
2003年 | 41篇 |
2002年 | 40篇 |
2001年 | 33篇 |
2000年 | 30篇 |
1999年 | 32篇 |
1998年 | 23篇 |
1997年 | 25篇 |
1996年 | 16篇 |
1995年 | 12篇 |
1994年 | 11篇 |
1993年 | 8篇 |
1992年 | 5篇 |
1991年 | 8篇 |
1990年 | 6篇 |
1989年 | 6篇 |
1988年 | 6篇 |
1987年 | 4篇 |
1986年 | 2篇 |
1985年 | 4篇 |
1984年 | 4篇 |
1983年 | 1篇 |
1982年 | 3篇 |
1980年 | 1篇 |
1977年 | 1篇 |
1976年 | 2篇 |
排序方式: 共有1154条查询结果,搜索用时 31 毫秒
1.
Iria Montero Prez Laura Rodríguez‐Pazos Adriana lvarez‐Prez MªMercedes Pereiro Ferreirs Carlos Aliste Jose Manuel Suarez‐Pearanda Jaime Toribio 《Journal of cutaneous pathology》2015,42(11):889-893
Classical Kaposi sarcoma (KS) usually appears on lower extremities accompanied or preceded by local lymphedema. However, the development in areas of chronic lymphedema of the arms following mastectomy, mimicking a Stewart–Treves syndrome, has rarely been described. We report an 81‐year‐old woman who developed multiple, erythematous to purple tumors, located on areas of post mastectomy lymphedema. Histopathological examination evidenced several dermal nodules formed by spindle‐shaped cells that delimitated slit‐like vascular spaces with some red cell extravasation. Immunohistochemically, the human herpesvirus type 8 (HHV‐8) latent nuclear antigen‐1 was detected in the nuclei of most tumoral cells confirming the diagnosis of KS. Lymphedema could promote the development of certain tumors by altering immunocompetence. Although angiosarcoma (AS) is the most frequent neoplasia arising in the setting of chronic lymphedema, other tumors such as benign lymphangiomatous papules (BLAP) or KS can also develop in lymphedematous limbs. It is important to establish the difference between AS and KS because their prognosis and treatment are very different. Identification by immunohistochemistry of HHV‐8 is useful for the distinction between KS and AS or BLAP. 相似文献
2.
3.
4.
20例临床诊断为散发性病毒性脑炎的尸检和活检脑组织,通过单纯疱疹病毒多克隆抗体免疫组化和生物素标记单纯疱疹病毒DNA探针原位杂交研究,5例诊断为单纯疱疹病毒脑炎。结果说明:单纯疱疹病毒是国内散发性病毒性脑炎的重要病原;免疫组化和原位杂交是诊断单纯疱疹脑炎的两种敏感方法。 相似文献
5.
CG Teo 《Oral diseases》2002,8(S2):88-90
Oral hairy leukoplakia (OHL) and Kaposi's sarcoma (KS) are commonly encountered in the HIV-infected patient. A unique feature of OHL is non-cytolytic high level of replication of Epstein–Barr virus (EBV) in the glossal epithelium. The expression of viral-encoded anti-apoptotic proteins concomitant to replicative proteins probably underlies this phenomenon. The question of whether OHL arises from activation of EBV latent in the tongue, or from superinfection by endogenous EBV shed via non-glossal sites or by exogenous EBV remains unresolved. Human herpesvirus 8 (HHV8) is now seen as necessary but not sufficient cause of KS. Expression of HHV8-encoded oncogenic proteins in endothelial cells probably explains the aberrant proliferation of these cells in KS lesions. Studies into why KS is so commonly observed at the palate in HIV-infected patients may provide important clues to its pathogenesis. 相似文献
6.
7.
Claus Neurohr Patrick Huppmann Hanno Leuchte Martin Schwaiblmair Iris Bittmann Gundula Jaeger Rudolf Hatz Lorenz Frey Peter Überfuhr Bruno Reichart Jürgen Behr for the Munich Lung Transplant Group 《American journal of transplantation》2005,5(12):2982-2991
Bronchiolitis obliterans syndrome (BOS) is the limiting factor to long-term survival after lung transplantation. Previous studies suggested respiratory viral tract infections are associated with the development of BOS. To identify the impact of virus detection in bronchoalveolar lavage (BAL) fluid, we analyzed BAL samples from 87 consecutive lung transplant recipients for human herpesvirus (HHV)-6, Epstein-Barr virus, Herpes simplex virus 1/2, Cytomegalovirus, respiratory syncytical virus and adenovirus by PCR. Acute rejection, BOS and death were recorded for a mean follow-up time of 3.27 +/- 0.47 years. Results of PCR analysis and other potential risk factors were entered into a Cox regression analysis of BOS predictors and death. Only acute rejection was a distinct risk factor for BOS of all stages, death and death from BOS. HHV-6 was detected in 20 patients. Univariate and multivariate analysis revealed that HHV-6 was associated with an increased risk to develop BOS > orb = stage 1 and death, separate from the risk attributable to acute rejection. Identification of HHV-6 DNA in BAL fluid is a potential risk factor for BOS. Our results warrant further studies to elucidate a possible causal link between HHV-6 and BOS. 相似文献
8.
Lanari M Papa I Venturi V Lazzarotto T Faldella G Gabrielli L Guerra B Landini MP Salvioli GP 《Journal of medical virology》2003,70(4):628-632
Human herpesvirus 6 (HHV 6) has neurotropic and neuroinvasive properties. The virus has been found in the cerebrospinal fluid of many children with aseptic meningoencephalitis. Intrauterine transmission has been documented by HHV 6 DNA detection in cord blood specimens of apparently healthy newborns and in fetuses following spontaneous abortions. A patient is described with early neonatal afebrile seizures resulting from a congenital HHV 6 variant B infection disclosed by repeated detection of viral genome by polymerase chain reaction (PCR) in cerebrospinal fluid in the first days of life. At follow-up, magnetic resonance imaging (MRI) studies disclosed hyperintensities in the periventricular white matter and basal ganglia, associated with cerebral atrophy. Further follow-up at 18 months revealed poor neurological outcome with mild neurodevelopmental retardation, strabismus and hypertonia of legs. This report provides evidence of neurological involvement after HHV 6 vertical transmission, and the association with neurological sequelae. 相似文献
9.
目的:建立检测血清中人类疱疹病毒6型(HHV-6)抗体的间接免疫荧光方法(IFA),检测人群中HHV-6抗体的水平。方法:用HHV-6GS株感染脐血单个核细胞制备抗原片,建立检测血清中HHV-6抗体的IFA法,并对长春市人群血清中的HHV-6抗体水平进行检测。结果:成功地建立了检测XHV-6抗体的间接免疫荧光方法,对长春市人群血清中的XHV-6抗体水平进行检测表明,XHV-6抗体阳性率为65.2%。结论:建立了特异性的IFA法,用于HHV-6感染的调查。 相似文献
10.