高效液相色谱法测定红细胞内α-生育酚

目的：寻找一种测定红细胞内α-生育酚含量的较好方法。方法：将含有生育酚的肝素抗凝血离心后吸出血浆,剩余的红细胞用生理盐水洗涤后用氢氧化钾皂化,并加入联苯三酚以防止α-生育酚被氧化。再用正已烷提取红细胞内的α-生育酚,并进行高效液相层析。结果：α-生育酚浓度为0．927～9．267 μmol／L,线性关系良好,最低检测限为0．323μmol／L,变异系数1．3％,回收率100．2％。结论：该方法简单可靠,重复性好,并可从细胞水平上了解机体的抗脂质过氧化作用。     

How Do Young Adult Children Deal with Parental Divorce?

Abstract

Research during the last decades has paid great attention to the long-term developmental outcomes of parental divorce for young adult children in several domains of their life. Recently some studies have started to consider the qualitative aspects associated with the resolution process of this traumatic experience. This contribution is based on data drawn from in-depth interviews conducted with 30 Italian young adult children (20–26 years of age) who experienced parental divorce. The purpose is to provide a comprehension ofhow young adults deal with the past experience, as well as to examine the quality of the intergenerational exchange and to explore the young adults' future representations related to the topics of filial responsibility and personal family projects. Gender differences are also examined, comparing data of male and female interviewees.     

Visual spatial perception in adolescents and their parents: The X-linked recessive hypothesis

If high ability in visual spatial perception is determined by an X-linked recessive major gene, then the following pattern of correlations is expected across the four groups of parents and children, that is, the nother-son, father-daughter, mother-daughter, and father-son groups:r _MS=r _FD>r _MD>r _FS=0. In a sample of 129 adolescents and their parents, the Spatial Relations Test of the Differential Aptitude Test and the Identical Blocks Test showed the pattern of correlations expected under the above hypothesis, but the Water Level Test did not. The present results provide but limited support for the X-linked recessive hypothesis.A version of this paper was presented at the annual meeting of the Southern Society for Philosophy and Psychology, Birmingham, Alabama, April 4, 1980.     

“We Are at Risk Too”: The Disparate Mental Health Impacts of the Pandemic on Younger Generations: Nous Sommes Aussi à Risque: Les Effets Disparates de la Pandémie Sur la Santé Mentale des Générations Plus Jeunes

Objectives:The coronavirus 2019 (COVID-19) pandemic has resulted in profound global impact, with older adults at greater risk of serious physical health outcomes. It is essential to also understand generational differences in psychosocial impacts to identify appropriate prevention and intervention targets. Across generational groups, this study examined: (1) rates of precautions and adaptive and maladaptive health behaviors, (2) differences in levels of anxiety, and (3) rates of COVID-related concerns during Wave 1 of COVID-19 in Canada.Participants:We analyzed data from 2 Canadian population-based data sets: the Canadian Perspective Survey Series: Impact of COVID-19 survey (N = 4,627; March 29 to April 3, 2020), and Crowdsourcing: Impacts of COVID-19 on Canadians—Your Mental Health (N = 45,989; April 24 to May 11, 2020).Measures:We categorized generational age group. Participants self-reported changes in behaviors and COVID-related concerns, and a validated measure assessed anxiety symptoms.Results:There are generational differences in behavioral responses to the pandemic. Adaptive health habits (e.g., exercise) were comparable across groups, while changes in maladaptive health habits (e.g., substance use) were highest among younger age groups, particularly Millennials (15 to 34 years old). COVID-related precautions were also highest among the younger generations, with Generation X (35 to 54 years old) exhibiting the highest rate of precautionary behavior. Results also revealed that the highest rate of clinically significant anxiety is among Millennials (36.0%; severe anxiety = 15.7%), and the younger generations have the highest rates of COVID-related concerns.Conclusion:These early data are essential in understanding at-risk groups given the unpredictable nature of the pandemic and its potential long-term implications.     

Generational risks for cancers not related to tobacco,screening, or treatment in the United States

BACKGROUND:

To assess trends in cancer, the authors evaluated the risk of 1 generation compared with that 25 years earlier (generational risk) for 3 groupings of cancers: those related to tobacco; those that reflect advances in screening or treatment; and a residual category of all other cancers.

METHODS:

In individuals ages 20 years to 84 years, age‐period‐cohort models were used to summarize time trends in terms of generational risk and average annual percentage change for US cancer incidence (1975‐2004) and mortality (1970‐2004) rates associated with these 3 cancer groupings.

RESULTS:

Adult white men today developed 16% fewer tobacco‐related cancers and had 21% fewer deaths because of those cancers than their fathers' generation, whereas adult white women experienced increases of 28% and 19%, respectively, relative to their mothers. The incidence of commonly screened cancers rose 74% in men and 10% in women, whereas mortality fell 25% in men and 31% in women. For cancers that have not been linked chiefly to tobacco or screening, the incidence was 34% and 23% higher in white men and white women, respectively, than in their parents' generation 25 years earlier. Mortality in this residual category decreased 14% in men and 18% in women. Results among blacks were qualitatively similar to those among whites.

CONCLUSIONS:

Despite declining overall cancer death rates, adults are experiencing increased incidence of cancers that are not associated with tobacco or screening relative to their parents. Future research should examine whether similar patterns are exhibited in other modern nations and should identify population‐wide avoidable risks that could account for unexplained increases in these residual cancers. Cancer 2010. © 2010 American Cancer Society.