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1.
Jürgen Schlegel Beate Ullrich Gabriele Stumm Peter Gass Ina-Maria Harwerth Nancy E. Hynes Marika Kiessling 《Acta neuropathologica》1993,86(5):473-479
The present study investigated the expression of c-erbB-2 in 59 meningiomas, including different histological subtypes and anaplastic variants, by immunocytochemistry and molecular biological techniques. Immunohistochemistry using the monoclonal antibody FWP-51 directed against c-erbB-2-encoded oncoprotein gp185 demonstrated variable degrees of immunoreactivity in all meningiomas. The intensity of immunostaining correlated with the degree of expression as assessed by Western analysis in 28 meningiomas using polyclonal antiserum 21N. There was no correlation between the degree of expression and histological variants. Immunoreactivity of all menigiomas was distinctly less intense, however, than that of the human breast cancer cell line SK-BR-3, and slightly lower than that of brain metastases of breast and ovarian carcinomas that served as positive controls for both methods. By Southern analysis all meningiomas showed a single copy of the c-erbB-2 gene. Non-neoplastic arachnoid cap cells also exhibited c-erbB-2 expression and the degree of immunoreactivity was comparable with the majority of meningiomas. These data argue against an overexpression of c-erbB-2 in meningiomas, but rather indicate a cell-type-specific constitutive expression of the c-erbB-2 gene product in meningiomas and their putative progenitor cells. Since a subgroup of meningiomas is known to express progesterone receptors (PR), gp185 immunoreactivity was compared to the hormone receptor status using monoclonal antibody KD68. Fifty-six percent meningiomas showed PR immunoreactivity, but there was no statistically significant correlation with the degree of gp185 expression.This study was supported by a grant of the Tumorzentrum Heidelberg/Mannheim (M.K., No. 10028060) 相似文献
2.
Yei-Mei Peng Ph.D. David S. Alberts Vivian Graham Earl A. Surwit Sheldon Weiner Frank L. Meyskens Jr. 《Investigational new drugs》1986,4(3):245-249
The present study was undertaken to evaluate the systemic absorption and cervical tissue uptake of all-transretinoic acid (TRA), delivered via a collagen spongecervical cap delivery device in patients with intraepithelial cervical dysplasia. Ten patients with histologically proven mild or moderate cervical dysplasia were included in this pharmacologic study. The two TRA concentrations (0.05% and 0.372%) selected for study represent the starting and maximally tolerated doses used in phase I clinical trial. All-trans-retinoic-11-3H acid (3H-TRA, 500 Ci) was used to facilitate cervical tissue uptake studies. Cervical biopsies and post-treatment blood samples were obtained from each patient after TRA exposure. The uptake of TRA into cervical tissues four hours after drug administration was significantly increased at the maximally tolerated TRA dose. There was a rapid decrease in cervical tissue concentration of TRA at the 0.372% dose between 4 and 24 h after drug exposure, suggesting a relatively short elimination half-life of TRA in cervical tissues. HPLC analysis of post-treatment blood samples indicate that there was no systemic absorption of TRA after local cervical administration. 相似文献
3.
Karel Geboes Gert De Hertogh Marie-Astrid Van Caillie Peter Van Eyken 《Current Diagnostic Pathology》2007,13(6):479-489
Gastrointestinal polyps are common lesions that usually present singly or in small numbers. Although the term ‘multiple colorectal polyposis’ was originally applied to patients carrying at least 100 large intestinal adenomas, it has subsequently become broadened to include patients carrying multiple polyps regardless of their nature. Most of the non-adenomatous polyposis syndromes are hereditary. They can be classified according to the dominant type of polyp, their distribution in the gastrointestinal tract and their potential for the development of gastrointestinal cancers. This review summarises their main clinical, genetic and histopathological features. 相似文献
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可来福接头在深静脉置管中应用 总被引:2,自引:0,他引:2
目的 观察可来福接头在深静脉置管中的应用优势,方法 对260例深静脉置管成功的患者分别采用可来福接头及肝素帽封管,随机分为两组,160例采用可来福接头,100例采用肝素帽,、观察回血、堵管情况及留置时间。结果 可来福接头明显优于肝素帽。结论 可来福接头输液简便易行,节省时间,减少耗材。 相似文献
6.
目的:研究尖锐器械在低温灭菌过程中的保护方法。方法:将2012年9月~201 3年6月供应室清洗后的再生穿刺针类器械741个,随机分为头皮针软管组、尿管组,分别使用头皮针软管、尿管做成保护帽,对锐利器械采取保护措施,并与2010年1月~3月使用纱布保护套的335个尖锐器械作对比,对其保护效果进行研究。结果:头皮针软管组包装及器械完好性达100%;尿管组纸塑袋包装破损32个,破损率8.7%,10个器械发生损坏占2.7%;纱布组管纸塑袋破损71个,破损率21.2%,器械损坏29个,破损率8.66%;三组包装破损率比较P<0.05,头皮针软管组、尿管组器械破损率分别与纱布组比较P<0.05,差异均有统计学意义。结论:头皮针软管能保护尖锐器械及包装的完好性,可根据器械的规格型号及数量选取相应的保护措施,以达院感要求。 相似文献
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改良真皮帽双环法行乳房缩小整形术 总被引:8,自引:4,他引:8
目的:灵活应用真皮帽双环法行乳房缩小成形。方法:采用传统的双环法设计切口,外下象限辅助S形切口线,保留乳晕周围较大面积完整的真皮帽,切除乳房外下象限腺体组织,设计外上及内下两个腺体组织瓣交错连接固定成形,乳晕周围内外环真皮荷包缝合,修整乳晕周围及外象限多余皮肤,切口呈环形,辅助切口瘢痕较小。结果:术后三月随访,新乳房的大小和形态.乳头乳晕的位置和形态均满意,除具有良好的感觉及勃起功能外,还保留了泌乳功能。结论:用组织瓣旋转固定的改良真皮帽双环法行乳房缩小成形,手术操作简单,组织瓣及乳头乳晕供血丰富,组织损伤小,值得推广。 相似文献
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目的:探讨自制气管切开导管封管帽用于长期气管切开病人的封管效果。方法选择气管切开需长期封管的病人80例,随机分成观察组和对照组各40例。观察组使用自制封管帽封管,对照组使用自制消毒棉签封管,对比两组病人封管期间封管物因呛咳被喷出掉落的人均次数和呼吸道感染发生次数。选择其中30例病人清醒时分别使用棉签和封管帽封管进行自身对照,比较其舒适度。选择30名操作人员分别使用封管帽和棉签进行封管操作,操作后让其对两种封管方法进行使用评价和选择封管方法。结果两组病人封管期间封管物因呛咳被喷出掉落的人均次数和呼吸道感染发生次数比较差异有显著意义,P<0.05;30例病人用棉签和封管帽封管的舒适满意度分别是90.3%和70%,χ2=5.45, P<0.05。30例病人和30名操作人员均选择使用封管帽长期封管。结论自制封管帽体积小,与气管切开导管衔接较好,装卸方便,不易丢失或掉落;既方便吸痰,又不易污染,增加了护理人员的可操作性;可提高患者封管的舒适度和安全系数;容易规范气管切开的护理操作流程,有效降低因气管切开所致的医院感染率,值得长期气管切开病人推广应用。 相似文献