全文获取类型
收费全文 | 2751篇 |
免费 | 264篇 |
国内免费 | 48篇 |
专业分类
耳鼻咽喉 | 9篇 |
儿科学 | 62篇 |
妇产科学 | 57篇 |
基础医学 | 254篇 |
口腔科学 | 573篇 |
临床医学 | 230篇 |
内科学 | 462篇 |
皮肤病学 | 44篇 |
神经病学 | 50篇 |
特种医学 | 81篇 |
外国民族医学 | 1篇 |
外科学 | 304篇 |
综合类 | 247篇 |
预防医学 | 93篇 |
眼科学 | 25篇 |
药学 | 126篇 |
1篇 | |
中国医学 | 46篇 |
肿瘤学 | 398篇 |
出版年
2024年 | 6篇 |
2023年 | 87篇 |
2022年 | 130篇 |
2021年 | 179篇 |
2020年 | 161篇 |
2019年 | 162篇 |
2018年 | 168篇 |
2017年 | 111篇 |
2016年 | 111篇 |
2015年 | 98篇 |
2014年 | 183篇 |
2013年 | 157篇 |
2012年 | 118篇 |
2011年 | 153篇 |
2010年 | 103篇 |
2009年 | 126篇 |
2008年 | 111篇 |
2007年 | 96篇 |
2006年 | 91篇 |
2005年 | 80篇 |
2004年 | 65篇 |
2003年 | 58篇 |
2002年 | 56篇 |
2001年 | 45篇 |
2000年 | 38篇 |
1999年 | 39篇 |
1998年 | 30篇 |
1997年 | 36篇 |
1996年 | 11篇 |
1995年 | 21篇 |
1994年 | 25篇 |
1993年 | 11篇 |
1992年 | 15篇 |
1991年 | 24篇 |
1990年 | 4篇 |
1989年 | 14篇 |
1988年 | 14篇 |
1987年 | 14篇 |
1986年 | 5篇 |
1985年 | 29篇 |
1984年 | 14篇 |
1983年 | 14篇 |
1982年 | 13篇 |
1981年 | 20篇 |
1980年 | 3篇 |
1979年 | 7篇 |
1978年 | 2篇 |
1976年 | 2篇 |
1973年 | 1篇 |
1972年 | 1篇 |
排序方式: 共有3063条查询结果,搜索用时 15 毫秒
1.
Wuteng Cao Huabin Hu Jiao Li Qianyu Wu Lishuo Shi Biao Li Jie Zhou Xinhua Wang Junhong Chen Chao Wang Huaiming Wang Weihao Deng Yan Huang Yanhong Deng 《International journal of cancer. Journal international du cancer》2023,153(11):1894-1903
Neoadjuvant programmed cell death protein 1 (PD-1) blockade exhibits promising efficacy in patients with mismatch repair deficient (dMMR) colorectal cancer (CRC). However, discrepancies between radiological and histological findings have been reported in the PICC phase II trial (NCT 03926338). Therefore, we strived to discern radiological features associated with pathological complete response (pCR) based on computed tomography (CT) images. Data were obtained from the PICC trial that included 36 tumors from 34 locally advanced dMMR CRC patients, who received neoadjuvant PD-1 blockade for 3 months. Among the 36 tumors, 28 (77.8%) tumors achieved pCR. There were no statistically significant differences in tumor longitudinal diameter, the percentage change in tumor longitudinal diameter from baseline, primary tumor sidedness, clinical stage, extramural venous invasion status, intratumoral calcification, peritumoral fat infiltration, intestinal fistula and tumor necrosis between the pCR and non-pCR tumors. Otherwise, tumors with pCR had smaller posttreatment tumor maximum thickness (median: 10 mm vs 13 mm, P = .004) and higher percentage decrease in tumor maximum thickness from baseline (52.9% vs 21.6%, P = .005) compared to non-pCR tumors. Additionally, a higher proportion of the absence of vascular sign (P = .003, odds ratio [OR] = 25.870 [95% CI, 1.357-493.110]), nodular sign (P < .001, OR = 189.000 [95% CI, 10.464-3413.803]) and extramural enhancement sign (P = .003, OR = 21.667 [2.848-164.830]) was observed in tumors with pCR. In conclusion, these CT-defined radiological features may have the potential to serve as valuable tools for clinicians in identifying patients who have achieved pCR after neoadjuvant PD-1 blockade, particularly in individuals who are willing to adopt a watch-and-wait strategy. 相似文献
2.
IntroductionPredicting pathological complete response (pCR) for patients receiving neoadjuvant chemotherapy (NAC) is crucial in establishing individualized treatment. Whole-slide images (WSIs) of tumor tissues reflect the histopathologic information of the tumor, which is important for therapeutic response effectiveness. In this study, we aimed to investigate whether predictive information for pCR could be detected from WSIs.Materials and methodsWe retrospectively collected data from four cohorts of 874 patients diagnosed with biopsy-proven breast cancer. A deep learning pathological model (DLPM) was constructed to predict pCR using biopsy WSIs in the primary cohort, and it was then validated in three external cohorts. The DLPM could generate a deep learning pathological score (DLPs) for each patient; stromal tumor-infiltrating lymphocytes (TILs) were selected for comparison with DLPs.ResultsThe WSI feature-based DLPM showed good predictive performance with the highest area under the curve (AUC) of 0.72 among the cohorts. Alternatively, the combination of the DLPM and clinical characteristics offered a better prediction performance (AUC >0.70) in all cohorts. We also evaluated the performance of DLPM in three different breast subtypes with the best prediction for the triple-negative breast cancer (TNBC) subtype (AUC: 0.73). Moreover, DLPM combined with clinical characteristics and stromal TILs achieved the highest AUC in the primary cohort (AUC: 0.82) and validation cohort 1 (AUC: 0.80).ConclusionOur study suggested that WSIs integrated with deep learning could potentially predict pCR to NAC in breast cancer. The predictive performance will be improved by combining clinical characteristics. DLPs from DLPM can provide more information compared to stromal TILs for pCR prediction. 相似文献
3.
4.
目的探讨8周基础军训(basic military training,BMT)对入伍新兵血像中红细胞及其相关指标的影响,为指导科学的军事训练提供参考。方法数据来自新疆边防部队2015年度入伍的50名男性新兵,分别在BMT前后测定并记录受试新兵的红细胞计数、血红蛋白浓度及血清铁蛋白等。结果经过8周的BMT,新兵血液中血红蛋白浓度、红细胞计数及血清铁蛋白均显著下降(P0.05,P0.01)。结论 8周BMT可能导致入伍新兵发生运动性贫血,铁缺乏可能是其主要原因。 相似文献
5.
目的 应用Meta分析的方法评价进展期霍奇金病经化疗达完全缓解后巩固放疗的作用。材料和方法 在MEDLINE、CBMdisc数据库检索进展期霍奇金病化疗达完全缓解行巩固性放疗或不行巩固性放疗的前瞻性随机对照研究。对入选研究的总生存、无事件生存优势比进行Meta分析。结果 4项研究入选,以α=0.05为检验水准,巩固性放疗组与对照组(不作巩固性放疗)相比,5年总生存优势比=1.18,P=0.46;5年无事件生存优势比=1.05.P=0.83:巩固性侵犯野放疗组与对照组相比,5年总生存优势比=0.96,P=0.87。结论 进展期霍奇金病经化疗达到完全缓解后,巩固性放疗对总生存及无事件生存均无益处。 相似文献
6.
KAZUMI NOGUCHI JUN-ICHI TERANISHI HIROJI UEMURA NAOYA FUJIKAWA KAZUO SAITO TETSUO MURAI 《International journal of urology》2006,13(9):1259-1261
Antiandrogen withdrawal syndrome (AWS) is a well-established phenomenon in prostate cancer. However, responses to AWS are usually of limited duration, and a complete response (CR) is extremely rare. We present two patients who exhibited a chemical CR for more than 2 years after the discontinuation of steroidal antiandrogen chlormadinone acetate use. Whether patients who respond to antiandrogen withdrawal include a group of patients with a better prognosis remains uncertain. However, considering that the usual survival period of patients with hormone-resistant prostate cancer is approximately 12 months, both of the patients reported here, who are present in excellent physical condition, exhibiting an improved quality of life, and attending their hospital as outpatients, obviously acquired a prolonged survival because of AWS. 相似文献
7.
Shunichi Takaya MD Shunzaburo Iwatsuki Takashi Noguchi Hisaaki Koie Iman Zaghloul Raman Venkataramanan Thomas E. Starzl 《Surgery today》1989,19(1):49-56
The influence of experimentally induced hepatic dysfunction on the pharmacokinetics of Cyclosporine A (CsA) was determined
in dogs. The pharmacokinetics of oral (PO) and intravenous (IV) CsA were studied before and after 70 per cent hepatectomy
or complete bile duct ligation (CBDL). Changes in liver function were monitored by serial measurements of serum bilirubin,
and by the maximum removal rate (Rmax) and plasma disappearance rate (ICG-K) of indocyanine green (ICG). Concentrations of
CsA in whole blood were measured by HPLC. Seventy per cent hepatectomy caused significant liver dysfunction: the ICG-Rmax
decreased by 47.7±7.1 per cent (mean±SD) and the ICG-K decreased by 61.3±9.7 per cent during the first week after hepatectomy.
At the same time, the systemic clearance (CLs) of IV-CsA decreased by 43.9±8.2 per cent, the area under the concentration
curve (AUC) of IV-CsA increased by 35.4±20.8 per cent and the bioavailability of CsA decreased by 26.4±14.8 per cent. CBDL
also induced significant liver dysfunction: the ICG-Rmax decreased by 39.1±12.8 per cent and the ICG-K decreased by 65.6±3.6
per cent in the second week after the operation. During the same period, the AUC of PO-CsA decreased by 69.9±10.7 per cent
and the bioavailability of CsA also decreased markedly by 73.9±15.6 per cent. These data indicate that hepatic impairment
significantly influences the pharmacokinetics of CsA, not only by the changes in intestinal absorption, but also by those
in hepatic, metabolism. Dose adjustment is therefore necessary in the presence of hepatic dysfunction in order to maintain
an adequate blood concentration of CsA without causing side effects.
This research was performed in the Department of Surgery, University of Pittsburgh Health Center, University of Pittsburgh,
USA 相似文献
8.
Minoru Yagi Takeshi Mishina Tsukasa Fujishima Kazutoshi Date Hiroshi Saito Nobuo Suzuki 《Surgery today》1997,27(1):84-87
The acute onset of peritoneal signs and shock in a 7year-old boy who had been hit in the epigastrium by a log-seesaw mandated surgical treatment. Enhanced computed tomography (CT) demonstrated complete laceration of the pancreas as well as duodenal injury, and a duodenoduodenostomy with distal pancreaticogastrostomy was subsequently performed. Temporary external drainage of the stomach and distal pancreas led to an uneventful recovery in the early postoperative period. Although the patient's postoperative development was appropriate for his age, the orifice of the distal pancreas spontaneously closed 2.5 years following surgery. We present this report to stress the fact that every effort should be made to preserve the pancreas following abdominal injury in children. 相似文献
9.
目的探讨急非淋白血病完全缓解后巩固治疗与缓解期的关系。方法对30例坚持与未坚持完全缓解后巩固化疗的急非淋患者(每组15例)进行对照研究。比较两组患者的完全缓解期。结果两组患者入院时情况、治疗及达完全缓解时间经统计学处理无明显差异(P>0.05);而坚持巩固化疗组平均持续完全缓解期(19.8mo)明显长于对照组(8.4mo),统计学具有显著差异(P<0.01)。结论急非淋白血病达完全缓解后,坚持骨髓抑制性治疗对延长完全缓解期以达长期生存目的具有重要意义。 相似文献
10.
RYUJI FUKAZAWA TAKASHI SEKI MITSUHIRO KAMISAGO MASANORI WATANABE SHUNICHI OGAWA KUNIO YUGE TSUNEO HIRAYAMA 《Pediatrics international》1994,36(4):427-430
We experienced a congenital complete atrioventricular block infant who was born from a Ro/SS-A antibody positive mother. Ro/SS-A antibody was also found in this baby which was presumed to be mediated by the maternal placenta. Temporary cardiac pacing was required at birth and pacemaker implantation was performed at 9 months. At 11 months of age, the baby fell into shock and experienced multiple organ failure because of diabetes mellitus-induced coma. The association between congenital complete heart block and the Ro/SS-A antibody is well known. However, the accompaniment of insulin-dependent diabetes mellitus has not been reported previously. As the Ro/SS-A antigen appears in the cytoplasm of many tissues, the possibility of an association between Ro/SS-A antibody and diabetes mellitus is difficult to deny. We report this rare case to draw attention to the possibility that babies who are born from an Ro/SS-A antibody positive mother may develop diabetes mellitus as well as congenital complete heart block. 相似文献