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排序方式: 共有4485条查询结果,搜索用时 15 毫秒
1.
1-乙基-6-氟-1,4-二氢-4-氧代-7-(4-芳酰硫代氨甲酰基-1-哌嗪基)-3-喹啉羧酸的合成及抗菌作用 总被引:4,自引:1,他引:3
Thirteen new 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(4-aroyl-thiocarbamoyl- 1 piperazinyl)-3-quinoline carboxylic acids were prepared, Their structures were characterized by elemental analysis, IR, HNMR and MS spectra.Preliminary pharmacological tests indicated that some of compounds Ia~m possess strong inhibiting activity against Escherichia coli, Bacillus subtilis and Proteus at concentration of 100 μg/ml. 相似文献
2.
3.
We examine the relationships between glycemic carbohydrate and its effects on short-term satiety and food intake. Both high- and low-glycemic carbohydrates have an impact on satiety, but their effects have different time courses. High-glycemic carbohydrates are associated with a reduction in appetite and food intake in the short term (e.g., one hour), whereas the satiating effects of lower-glycemic carbohydrates appear to be delayed (e.g., 2 to 3 hours). There is no consistent evidence that an increase in blood glucose, either acute or sustained, is the primary determinant of their effects on food intake and satiety. Many other preabsorptive and postabsorptive signals for satiety exist and may be the determining factors. Further studies are needed to delineate the role of glycemic carbohydrates and their mechanisms of action in determining satiety. 相似文献
4.
MP Costi D Tondi M Rinaldi D Barlocco G Cignarella DV Santi C Musiu I Pudu G Vacca P La Colla 《European journal of medicinal chemistry》1996,31(12):1011-1016
A new series of N-(substituted)benzyl-1,8-naphthalimides 4, structurally related to the previously reported thymidylate synthase (TS) inhibitor naphthaleins 3, were synthesized and compounds tested for their inhibition of several species of TS. Moreover, their in vitro cytotoxicity together with antimycotic and antibacterial properties were assayed. While no activity was detected in the antibacterial tests, the m-nitro (4ae) and the p-nitro (4af) derivatives were found able to partially inhibit TS at low micromolar concentrations. Introduction of nitro or (substituted)-amino groups in position 4 of the naphthalic ring always led to less active compounds. 相似文献
5.
C.M. Reading 《Medical hypotheses》1981,7(8):1105-1108
The aetiology of Klinefelter's Syndrome is not known. The causative factor(s) must explain the hypogonadism, low androgen levels, the disordered carbohydrate metabolism and the commonly associated psychiatric conditions. A biotin deficient/dependent state can account for the above. A biotin deficient Klinefelter's Syndrome patients with the above is described. The possible role of biotin in the primary, secondary and tertiary prevention of Klinefelter's Syndrome needs further research. 相似文献
6.
Guy Nantel PhD 《Nutrition reviews》2003,61(S5):s34-s39
Attention to the different types of carbohydrates and their role in health and disease is relatively recent. FAO and WHO jointly published a report on carbohydrates in human nutrition in 1998, with a number of recommendations about increasing carbohydrate intake as a sound approach to the prevention of obesity. The glycemic index (GI) was recommended as a means of classifying foods on the basis of their potential for raising blood glucose; this concept was based on the understanding that the state of hyperglycemia that is observed following the intake of certain high-GI carbohydrate foods could constitute a risk factor for diseases of lifestyle. 相似文献
7.
合成了6个6-氨基-9-(N~4′-芳香基取代乙醛缩氨基硫脲)嘌呤衍生物,并进行了抗核型多角体病毒(NPV)活性实验。结果显示该类化合物对NPV的抑制活性可达67%。 相似文献
8.
作者合成了9个喹啉酮类新衍生物,其结构经红外光谱,核磁共振氢谱,质谱及元素分析证实,对合成的化合物TM-9进行抗骨质疏松活性测定,初步结果表明,目标化合物TM-9促进骨形成活性高于日本已上市的异丙氧基异黄酮。 相似文献
9.
磺胺噻二嗪硫酮衍生物的合成及其抑菌活性 总被引:1,自引:0,他引:1
利用药物化学骈合原理设计并合成了一系列新的3,5-二取代1,3,5-噻二嗪-2-硫酮类化合物,其结构经红外光谱,紫外光谱及元素分析证实,抑菌活性试验显示了良好的抑菌活性。 相似文献
10.