全文获取类型
收费全文 | 4108篇 |
免费 | 168篇 |
国内免费 | 83篇 |
专业分类
耳鼻咽喉 | 16篇 |
儿科学 | 180篇 |
妇产科学 | 61篇 |
基础医学 | 234篇 |
口腔科学 | 89篇 |
临床医学 | 130篇 |
内科学 | 830篇 |
皮肤病学 | 69篇 |
神经病学 | 110篇 |
特种医学 | 60篇 |
外科学 | 598篇 |
综合类 | 357篇 |
预防医学 | 413篇 |
眼科学 | 87篇 |
药学 | 438篇 |
中国医学 | 624篇 |
肿瘤学 | 63篇 |
出版年
2024年 | 10篇 |
2023年 | 40篇 |
2022年 | 54篇 |
2021年 | 111篇 |
2020年 | 83篇 |
2019年 | 336篇 |
2018年 | 241篇 |
2017年 | 155篇 |
2016年 | 91篇 |
2015年 | 79篇 |
2014年 | 153篇 |
2013年 | 200篇 |
2012年 | 184篇 |
2011年 | 204篇 |
2010年 | 133篇 |
2009年 | 97篇 |
2008年 | 79篇 |
2007年 | 84篇 |
2006年 | 61篇 |
2005年 | 44篇 |
2004年 | 52篇 |
2003年 | 31篇 |
2002年 | 33篇 |
2001年 | 38篇 |
2000年 | 29篇 |
1999年 | 22篇 |
1998年 | 20篇 |
1997年 | 11篇 |
1996年 | 15篇 |
1995年 | 13篇 |
1994年 | 14篇 |
1993年 | 12篇 |
1992年 | 9篇 |
1991年 | 8篇 |
1990年 | 14篇 |
1989年 | 7篇 |
1988年 | 11篇 |
1985年 | 123篇 |
1984年 | 190篇 |
1983年 | 147篇 |
1982年 | 183篇 |
1981年 | 152篇 |
1980年 | 144篇 |
1979年 | 134篇 |
1978年 | 119篇 |
1977年 | 90篇 |
1976年 | 106篇 |
1975年 | 72篇 |
1974年 | 59篇 |
1973年 | 57篇 |
排序方式: 共有4359条查询结果,搜索用时 15 毫秒
1.
2.
3.
4.
Chien-Hua Tseng Ben-Jei Tsuang Chun-Ju Chiang Kai-Chen Ku Jeng-Sen Tseng Tsung-Ying Yang Kuo-Hsuan Hsu Kun-Chieh Chen Sung-Liang Yu Wen-Chung Lee Tsang-Wu Liu Chang-Chuan Chan Gee-Chen Chang 《Journal of thoracic oncology》2019,14(5):784-792
Introduction
For never-smokers (smoked <100 lifetime cigarettes), lung cancer (LC) has emerged as an important issue. We aimed to investigate the effects of prevalence changes in tobacco smoking and particulate matter (PM) 2.5 (PM2.5) levels on LC in Taiwan, in relation to contrasting PM2.5 levels, between Northern Taiwan (NT) and Southern Taiwan (ST).Methods
We reviewed 371,084 patients with LC to assess smoking prevalence and correlations between the incidence of adenocarcinoma lung cancer (AdLC) and non-AdLC. Two subsets were selected to assess different AdLC stage trends and the effect of PM2.5 on survival of patients with AdLC.Results
From 1995 to 2015, the proportion of male adult ever-smokers decreased from 59.4% to 29.9% whereas the female smoking rate remained low (3.2% to 5.3%). AdLC incidence in males and females increased from 9.06 to 23.25 and 7.05 to 24.22 per 100,000 population, respectively. Since 1993, atmospheric visibility in NT improved (from 7.6 to 11.5 km), but deteriorated in ST (from 16.3 to 4.2 km). The annual percent change in AdLC stages IB to IV was 0.3% since 2009 (95% confidence interval [CI]: -1.9%–2.6%) in NT, and 4.6% since 2007 (95% CI: 3.3%–5.8%) in ST; 53% patients with LC had never smoked. Five-year survival rates for never-smokers, those with EGFR wild-type genes, and female patients with AdLC were 12.6% in NT and 4.5% in ST (hazard ratio: 0.79, 95% CI: 0.70–0.90).Conclusions
In Taiwan, greater than 50% of patients with LC had never smoked. PM2.5 level changes can affect AdLC incidence and patient survival. 相似文献5.
A. Montalto V. Piazza F. Albi R. Gherli C. Contento A. Palermo F. Musumeci 《Transplantation proceedings》2019,51(1):206-209
Background
Pump speed optimization in patients implanted with a ventricular assist device represents a major challenge during the follow-up period. We present our findings on whether combined invasive hemodynamic ramp tests and cardiopulmonary exercise testing (CPX) can help optimize patient management.Methods
Eighteen patients implanted with a HeartMate 3 (HM3) device underwent ramp tests with right heart catheterization (including central venous pressure [CVP], pulmonary artery pressure, pulmonary capillary wedge pressure [PCWP], and blood pressure) and echocardiography. Data were recorded at up to 4 speed settings. Speed changes were in steps of 200 revolutions/min (rpm). Evaluation of functional capacity by CPX was conducted according to the modified Bruce protocol.Results
Only 30% of patients had normal PCWPs at their original rpm settings. In going from lowest to highest speeds, cardiac output improved by 0.25 ± 0.35 L/min/step (total change, 1.28 ± 0.3 L/min), and PCWP decreased by 1.9 ± 0.73 mm Hg/step (total change, 6 ± 1.6 mm Hg). CVP and systolic blood pressure did not change significantly with rpm. The rpm assessment was adjusted based on test results to achieve CVPs and PCWPs as close to normal limits as possible, which was feasible in all patients. On CPX, all patients demonstrated good performance (peak VO2, 16.8 ± 3.5 mL/kg/min).Conclusion
Hemodynamic ramp testing provides an objective means of optimizing rpm, and has the potential to provide good exercise tolerance. 相似文献6.
7.
8.
9.
A. BACCARELLI† A. ZANOBETTI I. MARTINELLI‡ P. GRILLO† L. HOU§ S. GIACOMINI† M. BONZINI† G. LANZANI¶ P. M. MANNUCCI‡ P. A. BERTAZZI† J. SCHWARTZ 《Journal of thrombosis and haemostasis》2007,5(2):252-260
BACKGROUND: Consistent evidence has indicated that air pollution increases the risk of cardiovascular diseases. The underlying mechanisms linking air pollutants to increased cardiovascular risk are unclear. OBJECTIVES: We investigated the association between the pollution levels and changes in such global coagulation tests as the prothrombin time (PT) and the activated partial thromboplastin time (APTT) in 1218 normal subjects from the Lombardia Region, Italy. Plasma fibrinogen and naturally occurring anticoagulant proteins were also evaluated. METHODS: Hourly concentrations of particulate (PM10) and gaseous pollutants (CO, NO2, SO2, and O3) were obtained from 53 monitoring sites covering the study area. Generalized additive models were applied to compute standardized regression coefficients controlled for age, gender, body mass index, smoking, alcohol, hormone use, temperature, day of the year, and long-term trends. RESULTS: The PT became shorter with higher ambient air concentrations at the time of the study of PM10 (coefficient = -0.06; P < 0.05), CO (coefficient = -0.11; P < 0.001) and NO2 (coefficient =-0.06; P < 0.05). In the 30 days before blood sampling, the PT was also negatively associated with the average PM(10) (coefficient = -0.08; P < 0.05) and NO2 (coefficient = -0.08; P < 0.05). No association was found between the APTT and air pollutant levels. In addition, no consistent relations with air pollution were found for fibrinogen, antithrombin, protein C and protein S. CONCLUSIONS: This investigation shows that air pollution is associated with changes in the global coagulation function, suggesting a tendency towards hypercoagulability after short-term exposure to air pollution. Whether these changes contribute to trigger cardiovascular events remains to be established. 相似文献
10.
大气颗粒物健康效应生物学机制研究进展 总被引:11,自引:1,他引:10
大量流行病学研究发现,大气颗粒物的污染水平与心肺系统疾病的超额发病、死亡存在密切关联,但其毒理学机制尚未阐明。本文对近年来大气颗粒物毒理学研究进行综述,包括大气颗粒物对呼吸系统、心血管系统及神经系统的毒性作用,并对氧化应激损伤、细胞钙稳态失衡及激活关键转录因子等分子毒理学机制进行了初步的阐述。 相似文献