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排序方式: 共有57条查询结果,搜索用时 15 毫秒
1.
(口山)酮对老年小鼠抗氧化酶活性的影响 总被引:1,自引:0,他引:1
目的:探讨从穿心草中提取的三种黄酮类化合物(咄)酮(Xanthone,Xan) 对老年小鼠体内抗氧化酶活性的影响.方法:连续20天腹腔注射0.2μmol/L和0.02μmol/L的三种Xan,测定体内超氧化物歧化酶、谷胱甘过氧化物酶和过氧化氢酶的活性.结果:三种Xan均能不同程度地增加老年小鼠体内多种抗氧化酶的含量,作用强度依次为Xan-Ⅰ>Xan-Ⅲ>Xan-Ⅱ.结论:三种Xan对老年小鼠体内抗氧化酶的活性有不同程度的影响,提示Xan对机体的保护作用与其清除氧自由基、提高抗氧化酶的活性有关. 相似文献
2.
远志的化学成分研究Ⅲ 总被引:11,自引:0,他引:11
目的:研究远志益智安神的有效成分,为开发治疗老年痴呆症的新药及远志的质量控制奠定基础。方法:采用硅胶柱层析和Sephadex LH-20进行纯化,通过各种光谱数据进行结构鉴定。结果:从远志根皮95%乙醇提取物的石油醚萃取物和氯仿萃取物中分离得到了9个化合物,分别鉴定为α-菠甾醇葡萄糖苷(I),α-菠甾醇葡萄糖苷-6’-0-棕榈酸酯(Ⅱ),豆甾醇(Ⅲ),(28Z)-三十四碳烯酸(Ⅳ),1,7-dimethoxy-2,3-methylenedioxyxanthone(V),1,2,3,6,7-pentamethoxyxanthone(VI),1,2,3,7-tetramethoxyxanthone(Ⅶ),1,3,7-trihydroxyxanthone(Ⅷ)和1,6,7-trihydroxy-2,3-dimethoxyxanthone(IX)。结论:化合物Ⅳ新化合物,化合物I、Ⅱ和Ⅷ为首次从远志属植物中分离得到,化合物Ⅲ和Ⅸ为首次从远志植物中分离得到。 相似文献
3.
呫吨酮类衍生物抗肿瘤活性研究进展 总被引:3,自引:0,他引:3
呫吨酮是含氧杂环化合物的重要组成部分.此类化合物的生物活性与其三环骨架和骨架上取代基团的性质和位置有关.该文总结了一系列天然与合成的呫吨酮类衍生物的抗肿瘤活性,并且阐述了部分重要的抗肿瘤机制,详细介绍了一些呫吨酮类衍生物的抗肿瘤及其对靶点的作用,尤其是对蛋白激酶C调变作用的研究;还列举了部分具有癌症治疗效果的呫吨酮类化合物,包括DMXAA、普梭草素、芒果苷、降阿赛里奥、曼果斯廷等. 相似文献
4.
Xanthone is a phenolic compound found in a few higher plant families; it has a variety of biological activities, including antioxidant, anti-inflammatory, and anticancer properties. However, the molecular and cellular mechanisms underlying the activity of xanthone in allergic contact dermatitis (ACD) remain to be explored. Therefore, this study aimed to investigate the regulatory effects of xanthone in ACD in human keratinocytes (HaCaT cell), and human mast cell line (HMC-1 cell) in vitro and in an experimental murine model. The results demonstrated that treatment with xanthone reduced the production of pro-inflammatory cytokines and chemokines including interleukin (IL)-1β, IL-6, IL-8, and expression of chemokines thymus and activation-regulated chemokine (TARC) and macrophage-derived chemokine (MDC) in tumor necrosis factor (TNF)-α and interferon (IFN)-γ-stimulated HaCaT cells. Xanthone also suppressed the production of pro-inflammatory cytokines, chemokines, and allergic mediators in phorbol myristate acetate/A23187 calcium ionophore (PMACI)-stimulated HMC-1 cells. Xanthone significantly suppressed the phosphorylation of mitogen-activated protein kinases (MAPKs) and nuclear factor-kappa B (NF-κB) and activation of caspase-1 signaling pathway in vitro model. Additionally, xanthone administration alleviated 2,4-dinitrofluorobenzene (DNFB)-induced atopic dermatitis like-skin lesion by reducing the serum levels of immunoglobulin E (IgE), histamine, and pro-inflammatory cytokines and suppressing MAPKs phosphorylation. Xanthone administration also inhibited mortality due to compound 48/80-induced anaphylactic shock and suppressed the passive cutaneous anaphylaxis (PCA) reaction mediated by IgE. Collectively, these results suggest that xanthone has a potential for use in the treatment of allergic inflammatory diseases. 相似文献
5.
Beidou Zhou Chun Lei Xuemei Liao Hang Zhu Zhipeng Ruan Yuanyuan Fang Guifen Xu Yuli Chen 《中国药学》2022,31(10):738-745
In the present study, we evaluated the antitumor, anti-tyrosinase, anti-pancreatic lipase, antibacterial, antifungal, and anti-α‐glycosidase activities for all or a subset of 20 known compounds. They included 8 phenyl benzoates, 10 benzophenones, and 2 xanthones. Phenyl benzoate compounds 1–8 did not exhibit evident antitumor activity, which was consistent with existing theories. Compounds 16, 17, and 18 exhibited moderate anti-tyrosinase activity. In addition, compounds 11 and 18 exhibited moderate inhibitory activity against Candida albicans, and compound 20 exhibited stronger anti-α-glycosidase activity than quercetin, with an IC50 of approximately 2.45 μM. These results demonstrated that compounds 11, 16–18, and 20 were promising leads for further structural modification. 相似文献
6.
目的:提取分离和鉴定民族药紫红獐牙菜中的口山酮成分。方法:采用常压及加压硅胶柱层析等方法进行提取分离,用UV、IR、1H-NMR、MS波谱技术及有关理化性质进行分析鉴定。结果:从紫红獐牙菜乙醇提取物中的乙酸乙酯萃取部分分离鉴定出7个单体化合物,化合物Ⅰ为8-0-β-D-吡喃葡萄糖-1,3,5-三羟基口山酮;Ⅱ为1,5,8-三羟基-3-甲氧基口山酮;Ⅲ为1,3,5,8-四羟基口山酮;Ⅳ为8-0-β-D-吡喃葡萄糖-1,5-二羟基-3-甲氧基口山酮;另3个化合物正在鉴定中。结论:对该民族药中的有效成分之一———口山酮类成分进行了系统提取分离与鉴定 相似文献
7.
8.
Xue-Dong Yang Ning An Li-Zhen Xu Shi-Lin Yang 《Journal of Asian natural products research》2013,15(2):141-145
Three new xanthone glycosides, securixanside A ( 1 ), securixanside B ( 2 ), and securixanside C ( 3 ) were isolated from the stems of Securidaca inappendiculata . These compounds were characterized by spectrometric and chemical methods, including FABMS and one- and two-dimensional NMR experiments. 相似文献
9.
H.-D. Wang C.-Y. Tan X.-F. Bai B.-C. Lin 《Journal of Asian natural products research》2013,15(3):307-309
A new compound, named gentianopfluorenone (1), along with three known compounds,1-O-β-d-glucopyranosyl-5-hydroxy-3-methoxyxanthone (2), 1-O-[β-d-xylopyranosyl-(1 → 6)-β-d-glucopyranosyl]-7,8-dihydroxy-3–methoxyxanthone (3), and apigenin (4), were isolated from the whole herb of Gentianopsis paludosa. On the basis of spectral and chemical evidence, the structure of 1 was elucidated as 4,4a,6-trihydroxy-5-methoxy-fluoren-2,9-dione. Compounds 2–4 were isolated from the plant for the first time. 相似文献
10.
Neuroprotective effects of xanthone extract from Swertia punicea Hemsl against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse model of Parkinson’s disease 下载免费PDF全文
As a widely used traditional Chinese medicine (TCM), Swertia punicea Hemsl has exhibited effects on anti-hepatitis B virus (HBV), liver protection, hypoglycemic activity and cholecystitis. In this study, we confirmed that xanthone extract from Swertia punicea Hemsl (XSPH) improved the motor deficit, increased the levels of striatal dopamine (DA) and homovanilic acid (HVA), and alleviated the loss of tyrosine hydroxylase (TH)-positive neurons located in substantia nigra pars compacta (SNpc) in MPTP-induced mouse model of Parkinson’s disease (PD). In conclusion, the present results indicated that XSPH offered neuroprotective effects against the neurotoxicity of MPTP and it might be a potential treatment for PD. 相似文献