Manganese is associated with increased plasma interleukin-1β during pregnancy,within a mixtures analysis framework of urinary trace metals

Exposure to trace metals may impact reproductive health outcomes through perturbations in maternal immune signaling molecules. We conducted a cross-sectional study of 390 pregnant women from the LIFECODES birth cohort and investigated the associations between 17 urinary metals and five immune biomarkers measured in the 3rd trimester (median 26 weeks gestation). We used linear regression to estimate pair-wise associations and applied elastic net and Bayesian kernel machine regression to identify important contributing exposures analytes as well as non-linear effects. Maternal urinary manganese, nickel, and barium were positively associated with maternal plasma interleukin-1β (IL-1β). Elastic net and Bayesian kernel machine regression identified manganese as the dominant trace metal in association with IL-1β. An interquartile range difference in manganese (0.6 μg/L) was associated with a 29 % increase in IL-1β (95 % CI: 12.4–48.2). In conclusion, trace metal exposures were associated with biomarkers of immune perturbations, and this warrants further investigation.     

90岁以上长寿老人听力与发中微量元素的观察

作者对30名90岁以上老人作纯音测听、高频测听和发中微量元素检测,与<60岁组人进行比较。结果:老年组纯音全频率听阈与对照组相比差异非常显著(P<0.01),高频测听,90岁组随着频率提高,听到耳数越来越少。并观察到90岁组发中锌、镁微量元素均低于<60岁组,两组间有显著差异(P<0.01)。对90岁组老人听力的特点,发中锌、镁微量元素含量减少对老年性耳聋的影响进行探讨。     

冠心病患者血糖与微量元素的相关性研究

为探讨冠心病患者血糖与微量元素的关系，用电感耦合等离子体原子发射光谱法测定了７８例冠心病患者的６种微量元素变化，并与血糖做相关分析．结果冠心病患者高血糖组与正常血糖组相比，血清铁、铅、镉显著增高，锌和铬显著降低，Ｐ＜００５或００１，铜无显著性差异；血糖与血清铁、铅呈显著性正相关，与血清铬、锌呈显著负相关，而与铜、镉相关不显著．表明部分微量元素的不平衡构成对冠心病的危险因子———高血糖的促发作用，调整人群中微量元素的不平衡状态，对减少冠心病及糖尿病的发生可能有利     

特发性甲状旁腺功能低下（附13例分析）

本文观察分析了13例特发性甲状旁腺功能低下患者、查PTH6例。患者血清中除有本病低血钙、高血磷的固有特征外，其它微量元素也有改变，如血清镁值减低。这与文献[1]的报道相符。碱性磷酸酶2例明显升高。磷廓清率S例降低。肾小管磷重吸收率5例升高。放免甲功：抗甲状腺微粒体2例升高。T细胞亚群1例低于正常值。本病有家族性，与遗传有关。     

黑蔓不同部位微量元素的测定

为了了解吉林省长白县山区所产卫矛科雷公藤属植物黑蔓的药理作用,扩大它的药用部位和应用范围,我们从无机元素与中药药效有密切关系的角度出发,实验测出黑蔓含有Ba、Si、Cu、Fe、Zn、Sn、Co、Mn、Mg、Ca、Se等无机元素,本文重点对其中人体必需的微量元素Cu、Fe、Zn、Se作了定量分析。     

Influence of urbanization of the western coast of the United Arab Emirates on trace metal content in muscle and liver of wild Red-spot emperor (Lethrinus lentjan).

We hypothesized that increased ambient concentrations of metals, as a consequence of escalating urbanization and industrialization of the Gulf region will respond in increased contamination of edible fish species. In this study, we report concentrations of chromium, manganese, cobalt, copper, zinc, arsenic, cadmium, mercury and lead in meat and liver of wild Red-spot emperor (Lethrinus lentjan) from three sampling points at the UAE coast. Analysis was performed by the ICP-MS/microwave digestion. Our study has shown that meat and liver metal content was significantly higher in areas with higher industrial activity, although metal values did not exceed permitted levels of fish for human consumption.     

无机汞对男工内分泌和大鼠睾丸微量元素的影响

应用放射免疫分析法（ＲＩＡ）和流行病学调查，对４０名接触汞和４０名非接触汞男工进行了血清甲状腺激素、性激素水平和生殖功能的测定。结果表明，接触组男工的阳萎、早泄、性欲减退发生率和男工妻子的早产、自然流产发生率以及血清甲状腺激素（ＦＴ３和ＦＴ４）含量明显增多，每周性交次数和血清睾酮含量显著减少。上述各项与对照组比较差异非常显著。应用火焰光度法，对氯化汞染毒后大鼠睾丸组织的微量元素进行测定，实验组的锌值明显降低。结果提示氯化汞能够影响甲状腺激素、睾酮和锌元素水平。     

不同种的金银花中微量生物元素的分布规律

本文报告不同种的金银花中微量生物元素的分布规律:不同种的金银花中微量生物元素含量的对数与其元素的原子序数成线性关系,并呈现周期性。     

东莞市正常儿童头发中微量元素含量参考值的研究

目的探讨东莞市区幼儿园3～7岁学龄前正常儿童头发中微量元素含量均值,以此作为东莞市区儿童头发中微量元素正常参考值.方法采取在群体自愿参加者中,选出经体检无重要脏器病变,营养一般,身高、体重在均值以上(称正常儿童).在枕后贴发根部剪0.5g头发检测其锌、铁、钙、铜、锰、铅元素含量.结果在1125例受检儿童中(称普查儿,占适龄儿95%).筛选出621例儿童,占总受检儿童的55.2%.这621例正常儿中,他们头发中锌、铁、钙、铜、锰、铅元素的含量分别为:93.473μg/g、29.710μg/g、779.50μg/g、9.773μg/g、3.222μg/g、9.251μg/g.结论检测的结果显示,2003年东莞市区正常儿童与2003年普查儿童相比,正常儿童发中微量元素含量明显升高,但差异无统计学意义.2003年东莞市正常儿童发中微量元素均值与广州市正常儿童相比,显著低于广州市正常儿童.由此可见,正常儿童发中微量元素含量均值受地域影响而有较大差异.东莞市区儿童发中微量元素含量应参照东莞市正常儿童发中微量元素含量均值较为合理.     

原子吸收法测定茶叶中的微量元素和溶出率

用火焰原子吸收法测定了3种云南茶叶中的铜、锌、锰、铁和铬的含量及溶出率。其中铜、锌、锰、和铁的溶出率均是红茶和绿茶大于沱茶,铬的溶出率则相近。