针刺四关穴治疗偏头痛及其对一氧化氮水平的影响

目的：观察针刺四关穴治疗偏头痛的疗效及其对血浆一氧化氯(N0)水平的影响。方法：对38例偏头痛患者以针刺四关穴治疗，并于治疗前后作血浆N0水平测定。结果：经治疗，患者总有效率78．95％；治疗后血浆N0水平明显升高。结论：四关穴针刺治疗偏头痛有确切疗效，其机理可能与升高血浆N0水平有关。     

光明、太冲穴与中枢神经相关效应的观察

目的:观察针刺光明、太冲穴时,中枢不同区域的相关反应.方法:将19名正常志愿者随机分为1组(视觉刺激加单侧针刺组)7人,2组(视觉刺激加双侧针刺组)6人和3组(单纯针刺双侧穴组)6人.用功能性磁共振(fMRI)观察各组在针刺光明、太冲穴时视觉皮质区与相关脑区的反应.结果:发现视觉刺激及针刺进针时,视觉皮质的血氧饱和水平(BOLD)无明显变化(P＞0.25),但在进行单侧和双侧持续刺激时,发现大脑相关区域有BOLD变化.结论:针刺对单侧和双侧穴位的刺激均能改善大脑相关区域的BOLD,但与进行手法和视觉刺激无关.     

开四关配合子宫八阵穴针刺治疗慢性盆腔炎疼痛:随机对照试验

目的观察开四关配合子宫八阵穴针刺法治疗慢性盆腔炎疼痛的临床疗效。方法将60例患者随机分为治疗组、对照组,每组30例。治疗组采用开四关配合子宫八阵穴针刺法治疗,对照组口服盐酸左氧氟沙星胶囊、甲硝唑片。采用妇科检查(局部体征)、治疗前后盆腔积液深度及盆腔炎性包块大小的测定作为观察指标。结果治疗组总有效率为90.0%(27/30),优于对照组的83.3%(25/30)。两组治疗1个疗程、治疗2个疗程、治疗结束后局部体征评分与同组治疗前比较差异均有统计学意义(P<0.05),提示两组治疗后局部体征评分均有降低;两组治疗1个疗程、治疗2个疗程、治疗结束后局部体征评分比较差异有统计学意义(P<0.05),对照组治疗1个疗程局部体征评分低于治疗组,提示对照组短期效应方面优于治疗组,治疗组治疗2个疗程、治疗结束后局部体征评分低于对照组,提示治疗组远期疗效优于对照组。结论两组治疗方法治疗慢性盆腔炎疼痛均有效,开四关配合子宫八阵穴针刺法治疗慢性盆腔炎疼痛远期疗效优于常规药物治疗,可明显提高患者生活质量,为临床提供优势治疗方法。     

Effects of Hegu （LI 4） and Taichong （LR 3） on Vascular Dilation and Constriction in Migraine Patients

Hegu （LI 4） and Taichong （LR 3） are the Yuan- Primary acupoints of the Large Intestine and Liver Meridian, and are collectively named as Si Guan （four gates） point. Combined use of these two acupoints can harmonize yin and yang, regulate qi and blood, and balance ascending or descending. This paper attempts to study the effects of Si Guan point on the vascular dilation and constriction in migraine patients from the perspective of its feature.     

TREATING 100 CASES OF HEADACHE BY MAINLY NEEDLING FENGCHI AND TAICHONG

This article introduces the writers' experience in treating 100 cases of headache bymainly needling Fengchi (GB 20) and Taichong (LR 3). It is considered in TCM that headache ismostly caused by pathogenic wind, and there is a saying of "no wind, no headache". The combinationof the two points can expel both endogenous and exogenous wind. So we treat headache mainly withneedling Fengchi and Taichong. The result is good, especially for cluster headache and psychicheadache.'     

Treatment of 56 Cases of Pain of Supra-orbital Bone by Puncturing Siguan Acupoints

Pain of supra-orbital bone is very common in clinic The author achieved significant effect in treating 56 cases of pain of supra-orbital bone by puncturing Siguan （four gates） points. The report is as follows.     

不同参数针刺治疗原发性高血压的正交优化方案研究

目的:分析不同选穴、留针时间、针刺深度对原发性高血压患者24 h血压负荷及昼夜节律的影响,优选最佳针刺降压方案.方法:纳入48例临床病例,采用正交试验设计,按照3因素2水平,即选穴(人迎、太冲)、留针时间(15、30 min)、针刺深度(浅刺、深刺),分为8组,每组6例,观察针刺前后24 h动态血压负荷及血压昼夜节律的...     

电针太冲、足三里对自发性高血压大鼠心肌纤维化的改善作用

目的 观察电针对于自发性高血压大鼠（spontaneously hypertensive rats,SHR）收缩压及左心室血管紧张素Ⅱ（angiotensin Ⅱ,AngⅡ）,细胞外信号调节激酶1/2（extracellular-regulated kinase 1/2,ERK1/2）,胶原蛋白Ⅰ、胶原蛋白Ⅲ含量的影响,探讨电针抑制高血压心肌纤维化的作用机制。方法 将36只SHR随机分为模型组、电针组、药物组,每组12只,另设12只Wistar大鼠作为空白组。模型组和空白组只进行抓取和固定刺激,电针组大鼠选取双侧太冲、足三里穴进行电针刺激,药物组服用氯沙坦钾。实验周期21 d。实验结束后测量大鼠尾动脉收缩压,Masson染色观察大鼠左心室病理改变,酶联免疫吸附法检测大鼠左心室AngⅡ含量,qPCR检测大鼠左心室ERK1/2、胶原蛋白Ⅰ、胶原蛋白Ⅲ mRNA表达水平。结果 染色结果显示,电针组及空白组左心室心肌组织形态正常,模型组心肌组织间大量胶原纤维增生,药物组心肌组织间可见少量胶原纤维。与空白组比较,各时点模型组大鼠尾动脉收缩压均显著升高（P＜0.05);与模型组比较,治疗第14天、第21天电针组、药物组收缩压显著降低（P＜0.05）。与空白组比较,模型组大鼠左心室AngⅡ含量,ERK1/2、胶原蛋白Ⅰ、胶原蛋白Ⅲ mRNA表达水平均显著升高（P＜0.05）;与模型组比较,电针组、药物组大鼠左心室AngⅡ含量,ERK1/2、胶原蛋白Ⅰ、胶原蛋白Ⅲ mRNA表达水平均显著降低（P＜0.05）。结论 电针能够对AngⅡ、ERK信号通路产生影响,进而下调大鼠心肌胶原蛋白mRNA的表达,从而起到抑制高血压大鼠心肌纤维化的作用,这可能是针刺能够有效减缓高血压心脏损伤的机制之一。     

Influence of Electroacupuncture at Taichong （LR 3） and Ququan （LR 8） on Hepatic Hemodynamics

Objective： To observe the influence Taichong （LR 3） and Ququan （LR 8） on patients with chronic hepatic diseases. of electroacupuncture hepatic hemodynamics （EA） at in the Methods： Sixty cases with chronic hepatic diseases were randomly divided into a Taichong （LR 3） group and a Ququan （LR 8） group, 30 cases in each group, and were respectively treated with electroacupuncture at Taichong （LR 3） and Ququan （LR 8）. The blood flow results of the hepatic artery and portal vein by color ultrasonic test were used as the objective indexes, to compare and observe the hemodynamics changes of the hepatic artery and portal vein in the patients before and after EA. Results： After EA, in Taichong （LR 3） group, the average velocity, the lowest velocity, resistance indexes and the highest velocity of blood flow of the hepatic artery, and the highest velocity, average velocity of blood flow of the portal vein, blood flow volume of the portal vein （PVBF）, total blood flow volume of the liver （TLBF）, and Doppler blood perfusion indexes of the hepatic artery （DPI） were all statistically different from those before intervention （all P~O,O5）, In Ququan （LR 81 group, the highest velocity, average velocity, lowest velocity and resistance indexes of blood flow of the hepatic artery, and the highest velocity and average velocity of blood flow of the portal vein, and PVBF were significantly different from those before intervention （P〈0.05）. The TLBF and DPI were significantly different from those before intervention （P〈0.01）. All various indexes were not statistically different between the two groups. Conclusion： EA at Taichong （LR 3） and Ququan （LR 8） can speed up blood flow velocity of the portal vein, increase PVBF, increase the TLBF, increase the resistance indexes of the hepatic artery, decrease the blood flow velocity of the hepatic artery, and decrease DPI in the liver.     

电针“四关”组穴及其相应单穴对卒中后抑郁模型大鼠行为学及脑单胺神经递质含量影响

目的：对比观察电针“四关”组穴及其相应单穴对卒中后抑郁（ post-stroke depression, PSD）模型大鼠行为学能力及脑单胺神经递质含量的影响,探讨“四关”组穴的协同效应及可能的作用机制。方法雄性SD大鼠50只,其中空白组10只,造模成功的32只随机分为模型组、四关组、合谷组、太冲组,每组8只。采用大脑中动脉闭阻术后结合慢性不可预见性温和应激刺激及孤养法造PSD模型。治疗组大鼠分别使用电针“四关”、合谷、太冲穴治疗,30分钟/次/日,连续21天。采用糖水试验、敞箱试验观察大鼠行为学指标变化,采用高效液相色谱仪荧光检测法观察大鼠脑组织中下丘脑区去甲肾上腺素（ noradrenaline, NE ）、多巴胺（ dopamine, DA ）、5-羟色胺（5-hydroxytryptamine,5-HT）含量。结果（1）造模后,SD大鼠行为学指标及脑单胺神经递质含量较空白组均明显减少（P〈0．01）;（2）治疗后,四关组及太冲组大鼠的敞箱试验数据高于模型组（P〈0．01）,且太冲组直立次数治疗后与空白组无差别,而合谷组基本无变化且治疗后与模型组无差异（P＆gt;0．05）;治疗三组糖水消耗比逐步上升,且合谷组治疗后达到了与空白组无差别的水平（P＆gt;0．05）;（3）治疗后,四关组及太冲组大鼠脑单胺神经递质含量均显著增高（P〈0．01）,太冲组的NE、5-HT含量又明显高于四关组（P〈0．05）,而合谷组大鼠脑单胺神经递质含量显著低于四关组及太冲组（P〈0．01）。结论电针四关组穴及太冲穴均能显著增加PSD模型大鼠的行为学指标,其作用机制可能与下丘脑组织中单胺类神经递质的含量的增加有关;但四关穴治疗该病的协同效应并不突出,其机理有待进一步研究。