环丁砜在地面水中最高容许浓度的研究

作者对地面水中不同浓度的环丁砜进行了系统实验研究与现场调查。结果表明,环丁砜对水臭觉的实际阈浓度为10.6mg/L,对水的生化需氧过程无明显抑制作用,慢性毒性阈剂量为2.5mg/kg,最大无作用剂量为0.25mg/kg,无诱变性,280mg/kg无致畸性。据此,作者建议地面水中环丁砜的最高容许浓度为5mg/L,结合现场调查,认为该浓度是安全可行的。     

Thermoregulatory responses of the rabbit to subcutaneous injection of sulfolane

Earlier studies have shown that intraperitoneal injection of the industrial solvent sulfolane (tetrahydrothiophene-1,1-dioxide) caused a decrease in metabolic rate and a rapid, regulated hypothermia in mice and rats. In the present study, subcutaneous injections of 0, 100, 200, 400, 600, and 750 mg/kg sulfolane at an ambient temperature (T_a) of 10° C caused a dose-dependent decrease in colonic temperature (T_c) of rabbits. Metabolic rate (MR) remained unchanged during the initial phase of the hypothermia for all dose groups; but peripheral vasodilation, as indicated by an increase in ear skin temperature, was seen at the higher dose levels. The observed thermoregulatory response to sulfolane was a function of T_a. Thus, at T_as of 10 and 20° C, injection of 600 mg/kg sulfolane had no effect on MR but caused an increase in ear skin temperature. The magnitude of the hypothermia was similar at these two T_as, indicating the sulfolane-treated rabbits had some control over T_c. At a T_a of 28° C, however, the animals became hyperthermic upon injection of 600 mg/kg sulfolane.This research has been reviewed by the Health Effects Research Laboratory, US Environmental Protection Agency and approved for publication. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. This work was done while Dr F. S. Mohler held a National Research Council-EPA Research Associateship     

水中环丁砜气相色谱测定法研究

目的建立一种测定水中环丁砜的方法。方法采用气相色谱—氢火焰检测法。结果相关系数为;0.9982,线性范围0.015～0.200μg,检出限为:1.5mg/L。样品加标回收率为:96.7%～105.4%。结论本方法具有干扰小、线性范围宽、操作简便快捷、结果可靠的优点,适合于测定水中环丁砜的含量。