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Effect of slow-release sodium fluoride on cancellous bone histology and connectivity in osteoporosis 总被引:1,自引:0,他引:1
We have previously demonstrated that a treatment regimen of slow-release sodium fluoride (SRNaF) and continuous calcium citrate increases lumbar bone mass, improves cancellous bone material quality, and significantly reduces vertebral fracture rate in osteoporotic patients. In order to assess whether such treatment also improves trabecular structure, we quantitated cancellous bone connectivity before and following 2 years of therapy with SRNaF in 23 patients with osteoporosis and vertebral fractures. In addition, we performed bone histomorphometry on the same sections used for connectivity measurements. There was a significant increase in L2-L4 bone mineral density during therapy (0.827 ± 0.176 g/cm2 SD to 0.872 ± 0.166, p = 0.0004). Significant histomorphometric changes were represented by increases in mineral apposition rate (0.6 ± 0.4μm/d to 1.1 ± 0.7, p = 0.0078) and adjusted apposition rate (0.4 ± 0.3 μm/d to 0.6 ± 0.4, p = 0.016). On the other hand, trabecular spacing significantly declined (from 1375 ± 878 μm to 1052 ± 541, p = 0.05). Two-dimensional quantitation of trabecular struts on iliac crest histological sections disclosed significant increases in mean node number per mm2 of cancellous tissue area (0.22 ± 0.12 vs. 0.39 ± 0.27, p = 0.0077), the mean node to free-end ratio (0.23 ± 0.21 vs. 0.41 ± 0.46, p < 0.05), and in the mean node to node strut length per mm2 of cancellous area (0.098 ± 0.101 vs. 0.212 ± 0.183, p < 0.01). There were no significant changes in any of the measurements associated with free-end number or free-end to free-end strut length. When patients were divided into those with severe and mild-modest spinal bone loss (based upon initial lumbar bone density) the significant changes in connectivity occurred in patients with mild-moderate bone loss, but not in those with severe bone loss, suggesting that fluoride's effect is in part dependent on the presence of a certain critical amount of bone. This finding in combination with the previously reported increases in bone mass and bone material quality may explain the significant reduction in vertebral fracture rate observed with this particular fluoride regimen. 相似文献
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基于JSP技术开发的HIs系统应用程序经常将数据库层代码、页面显示代码以及控制流代码混在一起,实际上,这种混合开发方式会使大型医院信息系统的开发和系统后期维护变得异常困难,而通过分层的思想开发应用系统可以有效解决这些问题。在HIS应用程序开发过程中采用MVC三层架构可以实现对系统的分层开发,MVC三层架构的逻辑层实现业务逻辑代码部分,视图层实现页面设计代码部分,控制层实现流程控制代码部分。Struts为实现基于MVC架构的web应用程序开发提供了一个优秀的框架,利用Struts框架开发的应用程序具有程序结构清晰、后期维护工作量少、开发效率高等优点,特别适合应用于大型HIS系统的开发。 相似文献
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针对教育网站实际开发中要求内容容易更新、网站结构容易扩展、异构数据可以共享和传输、网站语种多样、客户端实现形式灵活的问题,探讨了选择StrutsCX作为开发框架的原因,并用实例简述了开发流程. 相似文献
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Anil S. Harugop R. S. Mudhol P. S. Hajare A. I. Nargund V. V. Metgudmath S. Chakrabarti 《Indian journal of otolaryngology and head and neck surgery》2012,64(3):248-251
To estimate the prevalence of neonatal nasal septal deviation and to identify the precipitating factors. 250 neonates were examined on the 2nd day using Gray’s struts for the presence of deviated nasal septum. Struts passing up to the 4 cm mark was taken to be normal, while struts getting stuck before the 4 cm mark was diagnosed to have deviated septum on that particular side. Out of 250 neonates, 49 had nasal septal deviation. There was significantly higher number of deviations in neonates of primiparas, emergency LSCS and in high birth weight babies. Neonatal septal deviation is quite common, being present in approximately 20% of all newborns. Greater amount of birth trauma increases its incidence further. 相似文献
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