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复方丹参滴丸对急慢性高粘滞血症模型血管内皮细胞分泌功能的影响 总被引:5,自引:0,他引:5
目的:观察复方丹参滴丸对高粘滞血症血管内皮分泌功能的影响,探索其作用机制。方法:复合因素(高分子右旋糖酐、肾上腺素、牛血清白蛋白)、长时间(112天)造成高粘滞血症慢性模型;一次性静脉注射高分子右旋糖酐。皮下注射(sc)肾上腺素造成急性高粘滞血症模型,分别用复方丹参滴丸进行治疗,观察血管肉皮细胞分泌功能的变化。结果:慢性高粘滞血症模型血浆血栓素B2(TXB2)和内皮素(ET)浓度非常显升高,而6-酮-前列腺素F1x(6-酮)浓度非常显降低;急性高粘滞血症模型血管内皮分泌功能无显变化;长期使用复方丹参滴丸能调整、改善血管内皮分泌功能的异常状态;复方丹参滴丸改善血管内皮分泌功能的即时效应不显。 相似文献
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Many women find the idea of a once-a-month contraceptive pill an attractive concept. Mifepristone has been shown to be effective as a contraceptive if administered in the early luteal phase. We tested the contraceptive efficacy of 200 mg of mifepristone on day luteinizing hormone (LH) + 2 in a group of 32 women who used a fertility monitor to identify the LH surge. We also recruited a control group, comprising 20 women who were trying to conceive. In this group, 12 women conceived during a total of 50 control cycles (probability of pregnancy 0.25-0.32). Women in the treatment group contributed to a total of 178 cycles and there were two pregnancies (probability of pregnancy 0.01). An LH surge was not detected in 34 cycles (19.1%). In 20 cycles (11.2%) this was due to imperfect use while 14 were monitor method failures (7.9%). Treatment with mifepristone in the early luteal phase did not disrupt the cycle length but women reported slight vaginal bleeding in 15% of the cycles. The combination of a home-use fertility monitor with once-a-month administration of mifepristone (especially if mifepristone is administered at the early luteal phase) is an acceptable contraceptive option with minimal side effects. Unfortunately, it is difficult to envisage how an easier way of defining the correct timing, which required less compliance, could be devised. 相似文献
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目的:观察五淋丸对异丙肾上腺素(Iso)诱发的大鼠心肌缺血的保护作用。方法:采用腹腔注射诱导大鼠致急性心肌缺血的动物模型。实验大鼠随机分为Iso模型组,阳性对照组和五淋丸大、中、小剂量组,观察各组大鼠心电图ST-iunction(J点)的位移、血清酶及血流动力学变化。结果:五淋丸大、中、小剂量组大鼠心电图J点的位移明显低于模型组(P〈O.05或P〈0.01);血清肌酸激酶((K)及乳酸脱氢酶(LDH)活性低于模型组(P〈O.01);血流动力学指标:左心室收缩压(LVSP)、左心室舒张末压(LVEDP)、左心室等容期压力最大变化速率(土dp/dtmax)显著高于模型组(P〈O.05或P〈0.01)。结论:五淋丸对异丙肾上腺素所致大鼠缺血心肌具有保护作用,其机制可能与其改善心肌缺血大鼠心脏的舒缩功能有关。 相似文献
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Furedi A 《Human reproduction update》1999,5(6):621-626
The warning issued by the UK Committee on Safety Medicines in October 1995, followed by their 'Dear Doctor' letter of October 18, 1995, that oral contraceptive pills containing gestodene or desogestrel were associated with a higher risk of venous thromboembolism has had a negative impact on public heath. A significant number of women either switched brands or ceased contraception altogether following the announcement. National data suggest a strong association between the pill scare and a substantial increase in the number of unintended pregnancies, particularly significant among younger women, with use of oral contraception falling from 40 to 27% of under 16s between 1995-1996 and 1996-1997. The resulting cost of the increase in births and abortions to the National Health Service has been estimated at about Pound Sterling 21 million for maternity care and from Pound Sterling 46 million for abortion provision. The level of risk should, in future, be more carefully assessed and advice more carefully presented in the interests of public health. 相似文献
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The relatively short history of hormonal contraception has been marked by a series of 'pill scares', all of which--after creating panic among users--were proven to be unfounded in terms of public health impact. The latest pill scare, provoked by regulatory action in the United Kingdom and the Federal Republic of Germany in response to the publication of a series of articles indicating a doubling of risk of deep venous thrombosis in users of oral contraceptives containing third-generation progestins, seems finally settled: both the British and the German Drug Regulatory Authorities have now reverted their verdict. The damage unfortunately stays: hundreds of thousands of women have been compelled to abandon the pill of their choice, often deciding to drop contraception altogether, thereby exposing themselves to unwanted pregnancy and--in a number of cases--to pregnancy termination. This latest episode should be turned into something positive: we need to learn that, in the case of drugs in widespread use, before restrictive action is taken--and except for very rare and specific instances--the scientific community must carry out an exhaustive debate on the reality and importance of the observed effects. Although the public should, in each instance, be properly informed, it is only after this process has been completed that restrictive action should be taken. It is hoped that, after this last episode, all concerned have learned this simple principle and will accept being guided by it from now on. 相似文献
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复方软伤伸筋丸治疗膝关节骨性关节炎临床研究 总被引:7,自引:0,他引:7
周成刚 《中国中医骨伤科杂志》2003,11(3):5-7
目的 :探讨复方软伤伸筋丸治疗膝关节骨性关节炎的疗效机理。方法 :采用单盲法将膝关节骨性关节炎患者 2 2 0例 ,随机分为软伤伸筋丸组 (治疗组 ) 1 60例 ,壮骨关节丸组 (对照组 ) 60例 ,对比分析两组临床疗效。结果 :1治疗组临床治愈率为 88.75 % ,总有效率为 99.3 5 % ;对照组临床治愈率为 2 3 .3 3 % ,总有效率为 91 .68% ,治疗组优于对照组 ,具有显著性差异 (P<0 .0 1 )。2复方软伤伸筋丸无毒副作用。3复方软伤伸筋丸的应用可使增生骨刺吸收 ,损伤半月板修复。结论 :复方软伤伸筋丸是一种治疗膝关节骨性关节炎安全有效药物。 相似文献
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降脂保肝丸治疗脂肪肝的研究 总被引:1,自引:0,他引:1
目的 观察降脂保肝丸对脂肪肝的治疗作用。方法 将 1 2 8例脂肪肝患者随机分为 2组 ,治疗组服用降脂保肝丸 ;对照组服用多烯康胶囊。对两组进行临床观察 1个疗程后比较疗效。结果 治疗组总有效率为 1 0 0 % ,治愈率为 80 % ;对照组总有效率为 40 % ,治愈率为6 .7%。治疗组疗效明显优于对照组 ,有非常显著性差异 (P <0 .0 1 )。结论 降脂保肝丸是目前治疗脂肪肝的有效药物 相似文献