中西医结合治疗复发性生殖器疱疹

生殖器疱疹近年来其发病率迅速增加,感染后易在骶神经节潜伏。根据复发性生殖器疱疹（RGH）的发病期和非发病期分别采用中药口服,加用阿昔洛韦及阿昔洛韦软膏配合治疗取得较满意的效果。     

复发性生殖器疱疹患者的免疫学研究进展

复发性生殖器疱疹(Recurrent genital herpes,RGH)是由单纯疱疹病毒(herpes simplex virus,HSV)感染引起的一种性传播疾病,主要由单纯疱疹病毒2型(HSV-2)引起[1],是一种常见的难治愈的性传播疾病.     

Improved immunogenicity of high-dose influenza vaccine compared to standard-dose influenza vaccine in adult oncology patients younger than 65 years receiving chemotherapy: A pilot randomized clinical trial

PurposePatients undergoing chemotherapy often fail to develop robust responses to influenza vaccination. Compared to standard-dose influenza vaccine (SD), high-dose influenza vaccine (HD) has shown improved immunogenicity and protection against influenza illness in adults 65 years and older. This study compared the immunogenicity and tolerability of HD to SD in adults younger than 65 years of age receiving chemotherapy.MethodsThis double-blind study randomized patients receiving chemotherapy to vaccination with either SD or HD influenza vaccine. Hemagglutination inhibition assays (HAI) were performed prior to and 4 weeks after vaccination. HAI were summarized as geometric mean titers (GMT), seroconversion rates, and seroprotection rates.ResultsA total of 105 subjects were enrolled in the trial (51 received SD and 54 received HD). Subjects were well matched for demographic and medical conditions. Both vaccines were well tolerated with no SAEs. Of the 100 subjects with evaluable data, seroconversion rates for all 3 influenza antigens & post-vaccination GMTs for H3N2 & B strains were significantly improved with HD compared to SD. Seroprotection was excellent and equivalent in both groups.ConclusionsTrivalent high-dose influenza vaccine can be safely administered to patients receiving chemotherapy with improved immunogenicity and seroconversion compared to standard-dose vaccine. Post-vaccination seroprotection rates were similar in both groups. A larger study is needed to show clinical benefits with HD in this population.This study was registered at ClinicalTrials.gov as NCT01666782.     

匹多莫德对复发性生殖器疱疹患者白介素-13水平的影响

目的:评价匹多莫德对复发性生殖器疱疹(RGH)患者治疗前、后外周血白介素-13(IL-13)水平的影响.方法:RGH患者43例作为观察组,采用阿昔洛韦和匹多莫德治疗;RGH患者40例作为对照组,单用阿昔洛韦治疗;21例正常健康人为正常组.应用ELISA法检测各组血清IL-13水平,观察治疗后复发率,并进行比较.结果:治...     

卡介菌多糖核酸联合泛昔洛韦治疗复发性生殖器疱疹的疗效及预防复发作用

目的：探讨卡介菌多糖核酸联合泛昔洛韦治疗复发性生殖器疱疹的疗效及预防复发作用。方法：选择70例复发性生殖器疱疹随机分为两组（对照组与联合组）。两组均予以口服泛昔洛韦片0.25g,2次/d,连用10d;后改为0.125g,2次/d,整个疗程共3个月。联合组在此基础上予以卡介菌多糖核酸1mL肌注,2次/周,连用3个月。对照组患者仅予以口服泛昔洛韦,剂量及疗程同联合组。观察两组患者治疗后临床效果及药物不良反应,并随访治疗结束后半年及1年内的复发率。结果：联合组治疗后临床总有效率为77.14%,明显高于对照组的42.86%（χ^2=8.57,P〈0.01）。联合组和对照组治疗期间出现药物不良反应6例和4例,症状均较轻,两组比较无统计学差异（χ^2=0.47,P〉0.05）。治疗结束后对治疗有效者均随访半年及1年内的复发率,联合组的复发率均明显低于对照组（P〈0.05或P〈0.01）。结论：卡介菌多糖核酸联合泛昔洛韦治疗复发性生殖器疱疹取得了较好效果,不良反应轻,并可降低其复发率,具有治疗和预防复发双重作用。     

中药对复发性生殖器疱疹模型神经节的超微结构和潜伏病毒的影响

目的探讨中药抗病毒胶囊治疗复发性生殖器疱疹的作用机理。方法采用豚鼠阴道接种HSV-2,造成初发生殖器疱疹模型,然后给予中药抗病毒胶囊及西药阿昔洛韦治疗,愈后用环磷酰胺腹腔注射加紫外线局部照射方法诱导复发性豚鼠生殖器疱疹模型,取脊髓神经节用透射电镜观察豚鼠模型各组织的超微结构变化及采用定量PCR测定神经节的潜伏病毒量。结果抗病毒胶囊能有效减轻组织超微结构的变化和减少神经节潜伏病毒量。结论中药抗病毒胶囊在复发性生殖器疱疹动物模型体内有阻止HSV-2对神经节的感染和破坏作用。     

RGH患者心理状况与疾病发展的相关性研究

目的:探究RGH患者的心理健康状况与疾病发展过程的相互关系,为本病的心理干预和健康指导提供更多的依据。方法:采用国际统一的抑郁自评量表(SDS)和症状自评量表(SCL-90),在疾病发展的不同阶段由专业人员调查80例RGH患者的心理健康状况,并在不同病程、复发次数等的患者间进行比较。结果:RGH患者SDS、SCL-90平均得分显著高于国内常模,SDS与SCL-90在对RGH患者焦虑、抑郁等心理状态评估的结果基本一致,无显著性差异(P>0.05)。RGH患者的SCL-90总分及抑郁、焦虑、偏执、恐怖因子均明显提高。病程长、复发频率高、伴有其他性传播疾病的RGH患者SDS、SCL-90得分明显提高(P<0.05),但复发次数、皮疹持续时间对患者心理状况的影响无显著差异(P>0.05)。患者在发病前SDS及SCL-90得分显著高于治疗后10d(P<0.01)及治疗后30d(P<0.05)。结论:RGH患者心理健康状况较差,以抑郁、焦虑、恐怖和偏执等症状较为显著,其心理状况与疾病的发展有密切关系。     

Definition and variation of human endogenous retrovirus H

We defined the abundant human endogenous retrovirus group HERV-H based on pol similarity. Among 3661 pol-containing elements, 1124 integrations were similar to HERV-H RGH2 pol using translated pol sequences. A clustering procedure lessened these to 234 representatives, amenable to detailed study. Among the 1124, 926 clustered into HERV-H and 106 into adjacent HERV-H-like, the remainder being more distant to HERV-H. The HERV-H group was divided into RTVLH2-like (705 elements) and RGH2-like (77 elements) subgroups. Among 926 HERV-H, LTR differences were 1-33%, 10% had env, 78% had gag, 66% had a histidine primer binding site (PBS), and 3% (both subgroups) had a phenylalanine PBS. Allelic differences in env were studied using a convenient temperature gradient gel electrophoresis (TGGE) method and a genomic single nucleotide polymorphism (SNP) search. A pattern of abundant defective elements and less abundant less defective ones led us to formulate a "midwife" master model where more complete elements help the others in trans to transpose.     

心理干预联合乌灵胶囊对复发性生殖器疱疹患者抑郁与焦虑状态的影响

目的观察心理干预联合乌灵胶囊对复发性生殖器疱疹（RGH）患者抑郁与焦虑状态的影响。方法将62例RGH患者随机分为2组。对照组采用常规治疗（丽珠风胶囊口服、斯奇康注射液肌注和夫坦霜外搽）：治疗组在常规治疗基础上加用乌灵胶囊口服与心理干预。观察两组患者临庆疗效并在治疗前、后采用抑郁自评量表（sDS）与Zungs焦虑自评量表（SAS）对患者的抑郁与焦虑状态进行评定。结果两组患者总有效率无差异且经治疗后SDS、SAS评分均有不同程度的改善，但心理干预联合鸟灵胶囊治疗组显著优于对照组（P〈0．05）。结论心理干预与乌灵胶囊联合治疗能有效改善RGH患者的抑郁、焦虑状态。     

心理干预对复发性生殖器疱疹患者疗效的临床研究

目的:探讨心理干预在复发性生殖器疱疹患者中的临床疗效,统计复发率。方法:将90例复发性生殖器疱疹患者随机分为干预组和对照组,干预组口服盐酸伐昔洛韦片联合心理干预,对照组单纯口服盐酸伐昔洛韦片,比较两组的临床疗效和复发率。结果:干预组总有效率(95.3%)明显高于对照组总有效率(70.0%),差异有统计学意义(χ2=9.496,P=0.002);对照组复发率(30.0%)明显高于干预组复发率(11.6%),差异有统计学意义(χ2=4.295,P=0.038)。结论:口服抗病毒药物联合心理干预治疗复发性生殖器疱疹临床疗效优于单纯口服抗病毒药物,且能明显降低其复发率。