Effects of a diet rich in Q-3 fatty acids on left ventricular geometry and dynamics in spontaneously hypertensive rats

Summary The aim of the present study was to investigate the chronic effects of a dietetic antihypertensive treatment on blood pressure, ventricular dynamics and geometry of the pressure loaded heart. Spontaneously hypertensive rats (SHR) received a standard diet enriched with 10% mackerel oil, containing 30% polyunsaturated Q-3 fatty acids, over a period of 70 days. As described previously the diet reduced blood pressure permanently by 40-50 mm Hg. Despite this reduction, the degree of left ventricular hypertrophy was only slightly (statistically insignificantly) reduced. This was probably a result of an increase in sympathetic tone as indicated by a raised pulse rate. On the other hand, the treatment prevented the development of eccentric hypertrophy, typical to the SHR, without changing the elastic material properties of the myocardium. Since the age-matched controls did not show significant degenerative alterations, protective effects at the level of myocardial tissue could not be demonstrated. Furthermore, future investigations need to investigate why myocardial contractility of the treated animals diminishes as observed in this study.     

Q-Td及J-Td变化对AMI预后的影响

目的探讨急性心肌梗死(AMI)患者Q-T间期离散度(Q-Td)和J-T间期离散度(J-Td)的变化及对AMI预后的影响。方法选择近年住院资料完整的AMI患者163例,分为存活组和死亡组,分别进行Q-Td及J-Td对比测量,并与正常对照组进行比较。结果AMI组Q-Td、J-Td均较正常对照组显著增加,住院期间死亡组Q-Td、J-Td较存活组有显著增加。结论AMI时Q-Td、J-Td显著增加,死亡者较存活者增加更为显著,此可作为识别AMI后高危人群的一个有价值的指标。     

辅酶Q_(10)胶囊缓解疲劳作用的研究

目的研究一种辅酶Q10胶囊对小鼠有否缓解疲劳功能。方法40只成年雄性小鼠随机分4组,3个辅酶Q10胶囊组,剂量分别为4.2、42.0、125.0mg/(kg.d),连续给予30d,灌胃量为0.02ml/(g.d);对照组给予同体积溶剂(大豆油)。末次给予30min后,进行负重游泳时间、血清尿素、肝糖原、血乳酸测定,比较各试验组之间的差异。结果125.0mg(kg.d)剂量组能延长小鼠负重游泳时间,减少小鼠游泳时血清尿素的产生,增加肝糖原储备(P0.05),与对照组比较,差异均有统计学意义;对游泳后血乳酸的产生及小鼠体重未见影响(P0.05)。结论该辅酶Q10胶囊对小鼠具有缓解疲劳功能。     

调Q开关紫翠宝石激光器治疗太田痣临床疗效分析

为了探讨紫翠宝石激光治疗太田痣的疗效，运用ＰｈｏｔｏＧｅｎｉｃａ－Ｔ＾１０激光器，对６９例患者进行多次局部照射，治疗间期１～３月，观察疗效。经过２～８次治疗后，３９例痊愈，显效２６例，有效４例，有效率９４．２％。婴幼儿疗效明显优于成年人。无１例留下癜痕，为目前治疗太田痣的一种安全、有效的方法。     

Analysis of a new fluoroquinolone derivative (Q-35) in human scalp hair as an index of drug exposure and as a time marker in hair

Summary Scalp hair samples were obtained every month for three months after administration from healthy male volunteers who participated in the phase I study of a new antimicrobial fluoroquinolone derivative (Q-35). Hairs were cut into 1 cm long pieces successively from the scalp end. Corresponding pieces of 5 hair strands were dissolved in 1M NaOH and assessed for Q-35 by HPLC. The drug was detectable in the hairs of all subjects taking either a single (400 mg,n = 6) or repeated oral doses of Q-35 (400 mg/day for 6.5 days, total 2600 mg,n = 6). The hair portions containing the drug were shown in most subjects to move outwards along the hair shafts month by month in proportion to the hair growth rate of about 1 cm/month. Q35 (600 mg/day) was also given to 6 healthy male volunteers for 6.5 days (total 3900 mg) and hair samples were obtained 1 and 3 months after administration. When Q-35 was analyzed along a single hair shaft, the drug was detectable only in 1–2 consecutive 1 cm long pieces, which were also shown to move outwards along the hair shaft with time. A detailed analysis revealed that the drug was contained only in 2–4 consecutive 2.5 mm long pieces of a single hair collected after 3 months, showing that there was no significant axial diffusion of the drug along the hair shaft with time. These findings indicate the utility of measuring this fluoroquinolone derivative in human scalp hair as an index of drug exposure and as a time marker for analyzing other drug(s) in hair.     

Q开关Nd:YAG激光与强脉冲光对鼠皮肤热休克蛋白70表达的影响

目的:确定Q开关1064 nm Nd:YAG激光与强脉冲光(IPL)对Wistar大鼠皮肤热休克蛋白70(HSP70)表达的影响.方法:Wistar大鼠20只,背部皮肤脱毛,平均分成3部分:近头侧区为正常对照组,中间区为IPL组,近尾侧区为YAG组.于照射后1天、1周、4周取大鼠皮肤标本,免疫组化技术检测HSP70的表达.结果:免疫组化显示:Q开关1064 nm Nd:YAG激光和IPL照射后1周,HSP70表达最为显著;照射后4周,HSP70表达下调,IPL组表达与正常对照组无差别,YAG组仍较正常对照组表达增强(P＜0.05);两光照组间于照射后1天、1周和4周HSP70表达差别有统计学意义(P＜0.05).结论:HSP70的表达强度与光照后组织热损伤的程度和深度有关,Q开关1064 nm Nd:YAG激光对大鼠皮肤的非剥脱性嫩肤作用较IPL强且持久.     

An increase of oxidized coenzyme Q-10 occurs in the plasma of sporadic ALS patients

We have compared plasma redox status of coenzyme Q-10 in 20 sporadic amyotrophic lateral sclerosis (sALS) patients with those in 20 healthy age/sex-matched controls. A significant increase in the oxidized form of coenzyme Q-10 (sALS=109.3+/-95.2 nM; controls=23.3+/-7.5 nM, P=0.0002) and in the ratio of oxidized form of coenzyme Q-10 to total coenzyme Q-10 (%CoQ-10) (sALS=12.0+/-9.3%; controls=3.2+/-0.9%, P<0.0001) were observed. Moreover, %CoQ-10 correlated significantly with the duration of illness (rho=0.494, P=0.0315). Our finding suggests systemic oxidative stress in the pathogenesis of sALS.     

Q及N型Ca2+通道在兔不全梗阻性不稳定膀胱中功能的初探

目的:对Q及N型Ca2 通道在兔不全梗阻性不稳定膀胱中的功能进行研究。方法:成年同龄雄性新西兰白兔30只,其中15只为对照组(仅仅手术游离兔膀胱颈而不做结扎梗阻为对照组),15只为膀胱出口不全梗阻8周尿流动力学证实为不稳定膀胱者为实验组。模型成熟后,采用急性酶法分离及传代培养的方法获得单个膀胱平滑肌细胞。运用膀胱平滑肌M受体激动剂和Q及N型Ca2 通道阻滞剂,进行共聚焦显微镜检测其Ca2 浓度变化;了解膀胱平滑肌细胞是否存在Q及N型Ca2 通道;运用免疫组织化学方法进一步证实膀胱平滑肌细胞上是否存在Q及N型Ca2 通道及其变化。结果:共聚焦显微镜及免疫组化均证实膀胱平滑肌细胞膜存在Q及N型Ca2 通道,且不稳定膀胱平滑肌细胞膜之Q及N型Ca2 通道数量明显增多。结论:膀胱平滑肌细胞Ca2 及其通道病理性改变是出现不稳定膀胱的重要因素之一。     

扩张型心肌病,高血压性心脏病心功能不全患者Q—Td,Q—Tcd观察

为评价心功能不全患者Q-T_d、Q-T_d的临床应用价值,观察扩张型心肌病心功能不全患者(n=19)和高血压性心脏病心功能不全患者(n=20)Q-T、Q-T_c,并与健康成人(n=30)作对比。结果显示扩张型心肌病组与高血压性心脏病组Q-T_d无显著性差异(P>0.05),Q-T_(cd)有显著性差异(P<0.05),但均显著高于对照组(P<0.01),认为Q-T_(cd)比Q-T_d更能准确反映心肌复极离散程度。扩张型心肌病心功能不全患者Q-T_d、Q-T_(cd)增加最显著可能与其预后不良有关。