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In order to analyze the epileptogenic mechanisms of caffaine and related xanthines, putative effects of these drugs were studied on adenosine receptors of CA3 neurons in hippocampal slices. Epileptogenic concentrations of different xanthine derivatives strongly correlated with their affinities for the inhibitory A1 adenosine receptor subtype. The A1 receptor agonists adenosine and R-PIA reversibly depressed xanthine-induced epileptic activity without effects on the resting membrane potential or on spontaneously occuring action potentials. These findings suggest that the epileptogenic potency of xanthines is primarily due to the blockade of the A1 receptors through an abnormal rise of intracellular cAMP and to the excessive transmembrane calcium fluxes underlying paroxysmal depolarization shifts. 相似文献
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Roland Domann Thomas Dorn Otto W. Witte 《Pflügers Archiv : European journal of physiology》1991,417(5):469-478
Epileptic discharges were induced by superfusion of rat hippocampal slices with penicillin. Under these conditions the neurons generated paroxysmal depolarization shifts (PDS) after electrical stimulation of Schaffer collaterals. The PDS were followed by large afterhyperpolarizations lasting about 2 s. The mechanisms causing these afterhyperpolarizations were studied in CA1 pyramidal cells. A late component of the after hyperpolarizations, which determined their overall duration, was blocked by intracellular application of EGTA and reduced by superfusion with 8-Br-cAMP. In the same neurons these drugs had a comparable effect on after hyperpolarizations following depolarizing current injections; it was therefore concluded that the late component of the PDS afterhyperpolarizations was caused by a slow Ca2+-activated K+ current. An initial fast component of PDS afterhyperpolarizations, which peaked about 60 ms after PDS onset, was reduced by EGTA but not affected by 8-Br-cAMP suggesting that the fast Ca2+-activated K+ current also contributed to the PDS afterhyperpolarizations. Superfusion of the slice with the -aminobutyric acid B receptor (GABAB) antagonists phaclofen or 5-aminovalerate reduced the amplitude of the afterhyperpolarizations during the first 1000 ms but did not affect the late Ca2+-dependent component, indicating that a GABAB-mediated K+ inhibitory postsynaptic potential (IPSP) contributed to the PDS afterhyperpolarization. Intracellular injection of Cl– revealed that an early part of the afterhyperpolarizations lasting about 500 ms was Cl–-dependent. This component was blocked by superfusion of the slices with bicuculline, suggesting that a GABAA-mediated Cl– IPSP contributed to the PDS afterhyperpolarization. The experiments show that different synaptic and intrinsic components with different time courses participate in the generation of PDS afterpotentials. 相似文献
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J. Walden H. Pockberger E. -J. Speckmann H. Petsche 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》1986,64(3):607-609
Summary Epileptic activity was elicited in the rat's motor cortex by local application of penicillin. At the neuronal level it consisted
of typical paroxysmal depolarization shifts. The calcium agonist BAY K 8644 was injected into neurons showing such a discharge
pattern. The application of this drug increased amplitude and afterdepolarization of paroxysmal neuronal depolarizations. 相似文献
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目的分析急诊救治突发性脑出血的临床效果。方法选择在本院接受治疗的突发性脑出血患者280例,依照发病至急救时间的差异将其分成〈15min组与≥15min组,每组各140例,并将所选患者通过改良后的早期预警系统进行评分,比较两组患者的预后,以及在急诊救治后患者的出血量、并发症发生率、病死率以及不同早期预警评分患者的死亡率等相关指标。结果两组患者在出血量、病死率、早期预警评分以及不同早期预警评分患者的死亡率等方面,差异均有统计学意义(P〈0.05)。结论抢救时间对患者预后及生存率均有重要影响,急诊救治时要及时掌握患者病情.以赢得治疗时间。 相似文献
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《Seminars in hematology》2018,55(3):118-123
The complement cascade is an ancient defense system that destroys and eliminates threats to normal homeostasis in the bloodstream and tissues. Although multiple controls keep complement in check to minimize innocent bystander injury to normal cells and tissues, defects in complement regulation due to mutations in, or autoantibodies to, complement control proteins underlie the pathogenesis of several hemolytic diseases including paroxysmal nocturnal hemoglobinuria, and atypical hemolytic uremic syndrome. In autoimmune hemolytic anemias complement plays an important role in erythrocyte destruction mediated by antierythrocyte antibodies. The pathogenic mechanisms of these hemolytic diseases are discussed, with an emphasis on pivotal steps in complement activation. 相似文献
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