Nonpancreatic Pancreatic Panniculitis: An Incidental Finding in Individuals without Pancreatic Disease? A Case Series and Review of the Literature

Pancreatic panniculitis occurs in up to three percent of all patients with pancreatic disease. This cutaneous eruption, as implied by the name, is almost exclusively encountered in the context of pancreatic disorders, such as pancreatitis or pancreatic carcinoma. We report three cases in which histopathologic examination demonstrated hallmarks of pancreatic panniculitis occurring in patients without any history or evidence of pancreatic disorder. These nonpancreatic pancreatic panniculitis eruptions might be underreported in the literature.     

All-<Emphasis Type="Italic">trans-</Emphasis>retinoic acid-induced erythema nodosum in patients with acute promyelocytic leukemia

Erythema nodosum associated with all-trans-retinoic acid (ATRA) for acute promyelocytic leukemia (APL) is very rare. We describe four patients with classic APL who developed erythema nodosum during ATRA therapy. Fever and subsequent multiple painful erythematous nodules over extremities developed on D11, D16, D17, and D19, respectively, after ATRA therapy. The skin biopsy taken from each patient was consistent with erythema nodosum. All patients received short course of steroids. Fever subsided rapidly and the skin lesions regressed completely. All patients achieved complete remission without withdrawal of ATRA. ATRA seemed to be the most possible etiology of erythema nodosum in our patients. Short-term use of steroid is very effective in ATRA-induced erythema nodosum.     

Lupus erythematosus panniculitis: An immunohistochemical study

Summary An immunohistochemical study on a case of lupus erythematosus panniculitis (LEP), without discoid lupus erythematosus (DLE) or systemic lupus erythematosus (SLE) signs, showed that the cells in skin infiltrates were immunologically committed lymphocytes (OKT4, OKT8, OKT11 and HLA-DR positive cells) and elements of the monocyte-macrophage lineage (Leu M3 and Leu M5 positive). No immunophenotypically identifiable B-lymphocytes were seen. Immunofluorescent IgG, IgM, C3 and C4 deposits were found in blood vessel walls of the deep dermis. These findings, similar to that described in the skin changes of SLE and DLE, suggest that immunological mechanisms are operative in localized LEP, where the dermal lesions are the only expression of the disease.     

皮下脂膜炎样T细胞淋巴瘤叠加红斑狼疮病理特征一例

患者男,49岁。因皮下结节9个月余,发热5 d,于2018年11月19日至我院就诊。患者9个月前无明显诱因全身出现多个散在直径2 ~ 5 cm皮下结节,曾于我院行皮损活检,提示“皮下脂膜炎,不除外皮肤T细胞淋巴瘤”,当时未予特殊处理……     

与结核相关的脂膜炎研究进展

【摘要】 脂膜炎病因繁多而复杂,感染为重要病因之一,在欧美等结核低发区,以链球菌感染最为常见,但在结核高发地区如我国,结核杆菌感染是脂膜炎的重要因素,以Bazin硬红斑和结节性红斑最为常见。Bazin硬红斑与结核关系最为密切,常表现为下肢屈侧结节、斑块,可出现溃疡,病理表现为小叶性脂膜炎。结节性红斑可作为结核的早期症状出现,可作为结核的预测指标,常表现为双下肢伸侧红斑、结节,极少破溃,间隔性脂膜炎是其病理特征。Bazin硬红斑和结节性红斑的抗结核治疗常可取得理想效果。因此,明确结核分支杆菌与脂膜炎的关系,在脂膜炎的治疗及预后方面,尤其在结核高发地区有着重要意义。     

乳腺癌合并脂膜炎一例

患者女性,52岁。1998年6月29日在外院行右乳癌改良根治术,术后病理为黏液腺癌,腋窝淋巴结转移14/14,ER ( )、PR( )、HER2( )。术后曾行化疗,右锁骨上区和内乳区辅助放疗和TAM辅助内分泌治疗。2001年12月出现纵隔内淋巴结转移,2003年2月右侧腋窝淋巴结转移,于2003年4月开始接受泰索帝联合顺铂化疗。化疗至第3个周期时,患者左侧锁骨下区胸壁红肿,皮肤温度高,左侧乳腺红肿胀痛,同时伴有发热,体温波动于37.5℃～37.9之间。     

Scrotal fat necrosis after skiing

Fat necrosis in the scrotum is a rare lesion seen only before the age of puberty. The authors add one case of their own to three earlier reports. Common to most patients reported are the strict age limits between 9 and 12 years at the onset, exposure to cold, a tender mass in close connection with one or both testicles, and difficulties in differentiating this condition preoperatively from other forms of acute scrotum. Microscopic similarities with cold panniculitis are discussed. Offrint requests to: J. Viljanto     

Panniculitis with pseudomonas septicaemia in AIDS

A 27 year old female with acquired immunodeficiency syndrome (AIDS) developed tender erythematous nodules on her thighs. A skin biopsy of the lesions showed septal panniculitis and venulitis and Pseudomonas species was cultured from both the urine and the skin biopsy tissue. The lesions resolved on antibiotic therapy. Panniculitic nodules may represent an early stage of ecthyma gangrenosum which is a well recognised cutaneous complication of pseudomonas septicaemia.