Clinical and pathological portraits of axillary presentation breast cancer and effects of preoperative systemic therapy

There is a lack of investigation into the biological characteristics and preoperative systemic therapy (PST) for occult breast cancer (OBC).For this study,departmental records in Breast Disease Center of Peking University First Hospital from January 2008 to December 2015 were retrospectively reviewed to identify cases of OBC.Eleven cases were included,and all patients were female,with a median age of 56 (range:29-75) years.The sensitivity of magnetic resonance imaging (MRI) was 100％,and the false positive rate was 33.3％.Based on histologic analysis of the axillary node,9 (81.8％) cases were grade 3,and 2 (18.2％) cases were grade 2;4 (36.4％) cases were ≥10％ estrogen receptor (ER) positive and 6 (54.5％) human epidermal growth receptor 2 (HER2) positive.Nine cases (81.8％) exhibited over 30％ Ki67 expression.PST was performed in 5 of the 11 cases.The lymph node response rate was 100％ (5/5),but no complete remission was achieved.In conclusion,aggressive subtypes were predominant among the included cases,and PST should be considered for OBC treatment options.     

隐匿性乳腺癌的诊治探讨

目的探讨隐匿性乳腺癌的临床特点及诊治方法。方法对9例隐匿性乳腺癌患者的临床资料及疗效进行回顾性分析。结果术后9例患者中6例找到乳腺癌原发灶（3~8 mm）,随访1~8年,7例行乳腺癌改良根治术的患者中5例未出现局部复发或远处转移,1例术后1年发现骨转移灶,另1例术后1.5年死于脑、肺及骨转移;2例行保乳术的患者均无局部复发或远处转移。结论对有腋窝淋巴结转移腺癌而无明显原发癌灶的女性患者,应高度警惕隐匿性乳腺癌。治疗宜采用保乳术联合腋窝淋巴结清扫术,辅以全乳腺及区域淋巴结引流区放疗、化疗、内分泌治疗以及可能的靶向治疗。     

隐性乳腺癌20例诊治分析

目的：探讨隐性乳腺癌的诊断和治疗方法。方法：对20例隐性乳腺癌患者的临床资料进行回顾性分析。同侧乳腺根治性切除术10例，改良根治术7例，术后辅助化疗15例，术后加放疗5例，3例未手术的给予化疗加免疫治疗。结果：17例乳腺切除标本中见可疑肿物14例，最大直径1．0cm。术后随访12例，3例2年后死于肺转移，1例5年后死于其他疾病，8例随访6年仍存活。结论：乳头溢液和乳腺局限性腺体增厚对隐性乳腺癌的诊断有重要价值，活检有助于确诊；乳腺癌根治术或改良根治术后应辅以放、化疗。