全文获取类型
收费全文 | 1844篇 |
免费 | 40篇 |
国内免费 | 4篇 |
专业分类
耳鼻咽喉 | 15篇 |
儿科学 | 40篇 |
妇产科学 | 8篇 |
基础医学 | 221篇 |
口腔科学 | 7篇 |
临床医学 | 227篇 |
内科学 | 87篇 |
皮肤病学 | 5篇 |
神经病学 | 305篇 |
特种医学 | 63篇 |
外科学 | 574篇 |
综合类 | 82篇 |
预防医学 | 34篇 |
眼科学 | 2篇 |
药学 | 198篇 |
中国医学 | 18篇 |
肿瘤学 | 2篇 |
出版年
2023年 | 15篇 |
2022年 | 44篇 |
2021年 | 73篇 |
2020年 | 51篇 |
2019年 | 49篇 |
2018年 | 63篇 |
2017年 | 44篇 |
2016年 | 22篇 |
2015年 | 24篇 |
2014年 | 88篇 |
2013年 | 100篇 |
2012年 | 52篇 |
2011年 | 65篇 |
2010年 | 63篇 |
2009年 | 58篇 |
2008年 | 47篇 |
2007年 | 48篇 |
2006年 | 43篇 |
2005年 | 47篇 |
2004年 | 41篇 |
2003年 | 40篇 |
2002年 | 23篇 |
2001年 | 36篇 |
2000年 | 46篇 |
1999年 | 46篇 |
1998年 | 38篇 |
1997年 | 41篇 |
1996年 | 36篇 |
1995年 | 35篇 |
1994年 | 34篇 |
1993年 | 39篇 |
1992年 | 29篇 |
1991年 | 34篇 |
1990年 | 20篇 |
1989年 | 31篇 |
1988年 | 34篇 |
1987年 | 35篇 |
1986年 | 36篇 |
1985年 | 34篇 |
1984年 | 20篇 |
1982年 | 17篇 |
1981年 | 23篇 |
1980年 | 20篇 |
1979年 | 15篇 |
1978年 | 9篇 |
1977年 | 17篇 |
1976年 | 8篇 |
1975年 | 9篇 |
1974年 | 10篇 |
1973年 | 10篇 |
排序方式: 共有1888条查询结果,搜索用时 15 毫秒
1.
《Journal of hand therapy》2020,33(1):60-66
Study DesignClinical commentary.Introduction/PurposePain and movement are universally relevant phenomena that influence human experiences in readily observable ways. Improved understanding of pain-movement relationships can guide medical and rehabilitative approaches to recovery and decrease risk of dysfunctional long-term consequences of otherwise normal neuromuscular responses. Therefore, the overall intent of this article is to elucidate the relationships between pain and movement as they relate to clinical decision making.ConclusionsMotor output is highly adaptable, can be influenced by multiple mechanisms at various levels along the nervous system, and may vary between individuals despite similar diagnoses. Therefore, interventions need to be individualized and consider both the types of motor response observed (ie, whether the response is protective or maladaptive), and the patient's acute physical activity tolerance when prescribing exercise/movement. 相似文献
2.
Abstract: The use of neuromuscular electrical stimulation (NMES) for rehabilitation of gait in spinal patients is widely known. The best results can be obtained with the use of biomechanical sensors and a closed loop NMES system. One of the biggest problems faced in the design of control systems for closed-loop operation, in gait rehabilitation, is the variation of the mechanical conditions during the phases of gait. This work presents a new approach to ease the design of rule-based closed loop systems for operation in conditions such as gait rehabilitation. 相似文献
3.
4.
The bradycardia produced by 1 microgram acetylcholine in the isolated perfused rabbit heart, in the presence of vecuronium and atracurium, was studied and compared with control. Vecuronium at a concentration of 2.5 micrograms/litre and atracurium 6 micrograms/litre did not enhance the negative chronotropic effect of acetylcholine. Atracurium produced a statistically significant inhibition of the negative chronotropic effect of acetylcholine. 相似文献
5.
To examine the role of complement in certain autoimmune neuromuscular diseases, we used an in-vitro quantitative complement uptake assay that allows measurement of the capacity of patients' sera to deposit fragments of the third complement component onto sensitized targets. C3 uptake was significantly higher in patients with active dermatomyositis, Guillain-Barré syndrome and myasthenia gravis, compared to inclusion body myositis and controls. The in-vitro C3 uptake assay supports the role of C3b neoantigen and Membranolytic Attack Complex deposition in the target tissues and may be a useful tool to monitor disease activity in patients with complement-mediated neurological disorders. 相似文献
6.
The concave and convex rib-vertebral angle (RVA) at levels T2–T12 was measured on AP radiographs of 19 patients with right convex idiopathic thoracic scoliosis and 10 patients with major thoracic right convex neuromuscular scoliosis. The difference between the angles on the concave and the convex sides, the RVAD, was calculated. The RVAs were also measured on radiographs from three animal groups in which spinal curves had been induced experimentally in a variety of ways. Group 1 comprised 16 rabbits that had been subjected to selective electrostimulation of the latissimus dorsi, the erector spinae and the intercostal muscles. Group 2 comprised four dead rabbits whose spines had been subjected to manual bending. Group 3 comprised eight rabbits that had undergone mechanical elongation of one rib. In both the idiopathic and the neuromuscular group, the convex RVA was smaller than the concave RVA between levels T2 and T8, with a maximal difference between T4 to T5. From T9 to T12 the concave RVA was smaller than the convex. The RVA in relation to the scoliotic segment, i.e. the apex level of the curve and the two neighbouring vertebrae above and below this level, showed similar results. With increasing Cobb angle the RVADs increased linearly with the greatest difference at the second vertebra above the apex. In the three experimental groups the pattern of the RVADs between T6 to T12 was basically similar to the findings of the clinical study. From the results of these clinical and experimental studies, it is concluded that the typical pattern of the RVAs on the concave and convex sides seems to be independent of the underlying cause of the spinal curvature. It is likely that the RVADs result from a passive mechanical adaptation of the ribs to the lateral curvature of the spine. 相似文献
7.
In order to compare an acceleromyograph (TOF-GuardTM ) with a mechanomyograph (Grass FT03), the dose–response relationship of rocuronium was simultaneously determined in both arms of 15 children aged 3–11 years during anaesthesia with thiopentone, alfentanil and nitrous oxide. Three subgroups of five children received rocuronium 120, 180 or 240 μg.kg−1 randomly. The effective doses to produce 50% and 95% depression of the first twitch of the train-of-four determined by acceleromyography were 206 and 337 μg.kg−1 , respectively, while these values determined by mechanomyography were 151 and 331 μg.kg−1 , respectively. The dose–response curve obtained by acceleromyography was steeper and shifted to the right compared with that obtained by mechanomyography (p < 0.0001). The difference between the effective dose producing 50% twitch depression determined by the two devices was highly significant (p < 0.0001). In 13 out of 15 children, the acceleromyograph control train-of-four ratio was significantly greater than unity. Although there was a good correlation ( r = 0.85) between simultaneous pairs of measurements of neuromuscular block, the acceleromyograph exhibited a bias of −25% relative to the mechanomyograph with wide limits of agreement (−62 to +12%). We conclude that acceleromyographic and mechanomyographic measurements should not be used interchangeably when determining the potency of muscle relaxants. 相似文献
8.
9.
Non-contractile Ca2+ mobilization (not accompanied by muscle contraction) occurs by the prolonged activation of nicotinic acetylcholine receptor in mouse diaphragm muscles treated with anticholinesterase. To elucidate the regulation properties of non-contractile Ca2+ mobilization by nicotinic receptor, the modes of action of competitive and depolarizing neurmuscular blockers were investigated. (+)-Tubocurarine (0.07–0.1 μM), pancuronium (0.05 μM) and -bungarotoxin (0.03–0.06 μM) decreased decay time (T2, duration of inactivation phase) without changes in rise time (T1, duration of activation phase) of non-contractile Ca2+ transients. These competitive antagonists also suppressed their peak amplitude at higher concentrations than those affectingT2. Contractile Ca2+ transients were not inhibited by these antagonists at the concentrations used. Decamethonium (1 μM), a depolarizing blocker, suppressed the peak amplitude of non-contractile Ca2+ transients without affecting their duration. In contrast, succinylcholine (0.3 μM) suppressed both peak amplitude andT1 without changingT2, presumably via the receptor desentization. Succinylcholine but not decamthonium inhibited contractile Ca2+ transients at the concentrations used. These results demonstrate that the activation and inactivation phase in non-contractile Ca2+ transients are independently regulated by nicotinic acetylcholine receptor. 相似文献
10.
The onset time and tendency to cumulation of pipecuronium and high-dose vecuronium were compared during nitrous oxide anaesthesia supplemented with a propofol infusion. Pipecuronium 0.06 mg.kg-1 had a similar duration of action to vecuronium 0.2 mg.kg-1 (49 vs 43). Patients who received vecuronium had a shorter onset time of neuromuscular blockade (p less than 0.01). Neither pipecuronium nor vecuronium showed marked cumulation. 相似文献