Masturbation to Orgasm Stimulates the Release of the Endocannabinoid 2-Arachidonoylglycerol in Humans

BackgroundEndocannabinoids are critical for rewarding behaviors such as eating, physical exercise, and social interaction. The role of endocannabinoids in mammalian sexual behavior has been suggested because of the influence of cannabinoid receptor agonists and antagonists on rodent sexual activity. However, the involvement of endocannabinoids in human sexual behavior has not been studied.AimTo investigate plasma endocannabinoid levels before and after masturbation in healthy male and female volunteers.OutcomesPlasma levels of the endocannabinoids 2-arachidonoylglycerol (2-AG), anandamide, the endocannabinoid-like lipids oleoyl ethanolamide and palmitoyl ethanolamide, arachidonic acid, and cortisol before and after masturbation to orgasm.MethodsIn study 1, endocannabinoid and cortisol levels were measured before and after masturbation to orgasm. In study 2, masturbation to orgasm was compared with a control condition using a single-blinded, randomized, 2-session crossover design.ResultsIn study 1, masturbation to orgasm significantly increased plasma levels of the endocannabinoid 2-AG, whereas anandamide, oleoyl ethanolamide, palmitoyl ethanolamide, arachidonic acid, and cortisol levels were not altered. In study 2, only masturbation to orgasm, not the control condition, led to a significant increase in 2-AG levels. Interestingly, we also found a significant increase of oleoyl ethanolamide after masturbation to orgasm in study 2.Clinical TranslationEndocannabinoids might play an important role in the sexual response cycle, leading to possible implications for the understanding and treatment of sexual dysfunctions.Strengths and LimitationsWe found an increase of 2-AG through masturbation to orgasm in 2 studies including a single-blinded randomized design. The exact role of endocannabinoid release as part of the sexual response cycle and the biological significance of the finding should be studied further. Cannabis and other drug use and the attainment of orgasm were self-reported in the present study.ConclusionOur data indicate that the endocannabinoid 2-AG is involved in the human sexual response cycle and we hypothesize that 2-AG release plays a role in the rewarding consequences of sexual arousal and orgasm.Fuss J, Bindila L, Wiedemann K, et al. Masturbation to Orgasm Stimulates the Release of the Endocannabinoid 2-Arachidonoylglycerol in Humans. J Sex Med 2017;14:1372–1379.     

Masturbation mimicking seizure in an infant

A 3.5-month-old boy was referred to our hospital with the diagnosis of infantile spasm. His developmental milestones and physical examination were normal. During the follow-up we recorded about six to nine attacks a day and the duration of attacks was changed between 15 seconds–1.5 minutes. During the episodic attacks he was flushed and had tonic posturing associated with crossing of thighs, without loss of consciousness and his eye movements were normal. Routine and long-term electroencephalogram (EEG) were normal during attack. The patient was diagnosed as masturbation according to the clinical and EEG findings. In conclusion, we would like to stress that masturbation should also be considered in infants who were admitted with complaint of seizure, and aside from EEG monitoring a detailed history and careful observation are very important factors in differential diagnosis of these two different conditions.     

山东某医学院480名高年级男生手淫现况调查

目的了解医学院大学生手淫的相关因素及手淫对生理健康的影响。方法采用整群抽样的方法,对某医学院高年级在校男生500人进行自填式问卷调查。结果63.5%（305例）的调查对象有手淫行为,其中5.2%的手淫者健康受危害。多因素logistic回归分析提示,独生子（OR=2.447,OR95%CI：1.591～3.858）、支持非婚性行为（OR=2.057,OR95%CI：1.233～3.432）、看黄色书刊或者视频（OR=3.688,OR95%CI：1.230～11.063）、经常性幻想（OR=2.406,OR95%CI：1.523～3.800）、经常为性苦恼者（OR=1.817,OR95%CI：1.163～2.838）手淫习惯率明显高于对应人群;认为手淫有害者（OR=0.217,OR95%CI：0.121～0.387）手淫习惯率明显低于对应人群。结论医学院高年级男大学生的手淫行为已经影响到生理健康,对大学生进行性健康教育,预防过度手淫对健康的伤害非常必要。     

自慰在未婚慢性前列腺炎治疗中的价值

目的:探讨自慰在未婚慢性前列腺炎患者中的治疗价值。方法:对67例未婚男性青年(20-25岁)患有慢性前列腺炎患者,均口服依诺沙星0.2g2次/d,那妥25mg1次/d8周,随机抽取其中40例指导每周自慰1次,其中10人不遵医嘱每周自慰超过3次,共分为3组。8周后对3组的治疗效果比较。结果:在慢性前列腺治疗8周后,自慰组的治疗效果明显优于另两组。结论:自慰可以释放性冲动,减少性冲动时会阴部的充血,自慰达到性高潮时,可有利于前列腺液的排出,解除前列腺液在腺体内淤积所造成的一系列症状,对慢性前列腺炎的治疗是有价值的。     

Involuntary masturbation and hemiballismus after bilateral anterior cerebral artery infarction

Ischemia of the areas supplied by the anterior cerebral artery is relatively uncommon. In addition, combined hemiballismus and masturbation have rarely been reported in patients with cerebrovascular disease. We describe herein a 62-year-old right-handed man simultaneously exhibiting right side hemiballismus and involuntary masturbation with the left hand after bilateral infarction of the anterior cerebral artery territory. Right side hemiballismus was related to the disruption of afferent fibers from the left frontal lobe to the left subthalamic nucleus. Involuntary masturbation using the left hand was exclusively linked to a callosal type of alien hand syndrome secondary to infarction of the right side of the anterior corpus callosum. After 2 weeks, these abnormal behaviours were completely extinguished. This report stresses the wide diversity of clinical manifestations observed after infarction of the anterior cerebral artery territory.     

青年男性手淫合并慢性前列腺炎治疗分析

目的通过对青年男性手淫合并慢性前列腺炎治疗分析,阐述了习惯手淫诱发或加重青年男性慢性前列腺炎的病理基础,应引起足够重视.方法综合2009年至2011年4月青年男性慢性前列腺炎病例,比较用常规治疗和心理疏导等综合方法治疗127例的效果,并做统计分析.结果经门诊回访和统计学分析,常规治疗组有效34例,无效23例;综合治疗组有效63例,无效7例.结论戒除不良习惯、加强对症治疗、及时行心理疏导的综合方法是防治青年男性前列腺炎的有效措施.     

贵州省少数民族未婚男性青少年首次遗精及自慰状况调查

目的:了解少数民族未婚男性青少年首次遗精年龄及性自慰情况,并分析其影响因素。方法:在贵州省镇宁县、三都县、玉屏县和务川县,采用分层整群抽样的方法随机选取苗族、布依族、水族、仡佬族、侗族14～28岁未婚男性青少年各50名,进行问卷调查,运用SPSS11.5统计软件进行分析。结果:首次遗精年龄呈正态分布,P50=15岁,呈年代前移态势,城市年龄小于农村。40.8%男青年表示有自慰,不同民族间发生自慰的比例有统计学差异,民族、户籍和生殖健康知识来源影响自慰后的感受。结论:社会经济、文化传统通过人们的生活方式而影响着性生理和性活动的发生发展。为提高少数民族生殖健康水平,结合各民族民俗文化,开展尊重关心青少年性发育和性权力的生殖健康教育刻不容缓。     

Orgasmic Latency and Related Parameters in Women During Partnered and Masturbatory Sex

Introduction

Orgasmic latency (OL) during partnered sex (POL) and OL during masturbatory sex (MOL) in women with and without orgasmic difficulty have received minimal attention.

宿州地区高中生性心理健康现况

探讨宿州地区高中生的性心理健康状态,为提高青少年的性心理健康水平提供科学依据.方法 采用分层整群抽样方法,抽取宿州城镇和农村高中生共1 039名,进行青春期性心理健康问卷调查.结果 城镇学生生理知识、性知识、性观念、社会适应、自身适应、性认知分量表、性适应分量表得分均高于农村学生.在生理知识、性知识、性观念、社会适应、自身适应、性认知分量表、性适应分量表方面,男生得分高于女生;在性态度、性控制力、性价值观分量表方面,女生得分高于男生.在生理知识、性知识、性认知分量表方面,独生子女得分高于非独生子女,差异均有统计学意义(P值均<0.05).结论 宿州市农村学生、女生、非独生子女学生性心理健康状况相对较差.     

性自慰导致特殊膀胱异物4例报道

目的：探讨性自慰导致特殊膀胱异物的个性化治疗.方法：2011年4月至2013年1月,我院共收治了4例特殊性自慰膀胱异物,根据膀胱异物的种类进行个性化治疗,1例男性患者自行将直径约6mm、33粒磁性钢珠从尿道口塞进尿道后,钢珠坠入膀胱后自觉下腹坠胀,轻微尿痛,无尿频、尿急、排尿中断,我们自行设计前端镶嵌一磁珠的长塑料导管,将其经膀胱镜探入膀胱,吸引出全部钢珠;3例女性自行插入体温计、塑料管、毛笔杆,插入体温计者行膀胱镜下异物取出,余2例形成巨大膀胱结石,均由开放手术取出,其中1例患者病程长达12年,入院时诊断为双侧肾盂、输尿管重度度积水,双侧输尿管下段狭窄,膀胱结石,膀胱周围脓肿,急性肾盂肾炎,给予双侧肾盂穿刺造瘘术,控制感染后行膀胱切开取石术,后将结石电锯开后见其核心为毛笔杆.结果：4例患者均将膀胱异物全部取出,无明显膀胱功能障碍.结论：应仔细询问病史、分析病史,以免患者隐瞒病史而贻误治疗,根据膀胱异物的种类进行个性化治疗,最大限度减少患者的创伤,可自行设计特殊器械;尽量争取经膀胱镜下取出异物.