排序方式： 共有33条查询结果，搜索用时 31 毫秒
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Anna M. Georgiopoulos Deborah Friedman Elizabeth A. Porter Amy Krasner Sheetal P. Kakarala Breanna K. Glaeser Siena C. Napoleon Janet Wozniak 《Journal of cystic fibrosis》2018,17(2):276-280
Background
International guidelines recommend depression and anxiety screening in individuals with cystic fibrosis (CF), but Attention-Deficit Hyperactivity Disorder (ADHD) remains understudied.Methods
Adults with CF (n = 53) were screened using the Adult ADHD Self-Report Scale-v1.1 Symptom Checklist (ASRS-v1.1), Cystic Fibrosis Questionnaire-Revised (CFQ-R), and a self-report measure of treatment adherence.Results
Elevated ADHD symptoms on the ASRS-v1.1 screener were reported by 15% of participants. Self-reported adherence, Body Mass Index in kg/m2 (BMI), and Forced Expiratory Volume in 1 Second, Percent Predicted (FEV1%pred) did not differ between participants with vs. without elevated ADHD scores. Three CFQ-R scales, Physical Functioning, Role Functioning, and Respiratory Symptoms, were significantly lower in participants with elevated ADHD screens (unadjusted p < 0.05). This difference remained statistically significant for the Role Functioning and Respiratory Symptoms scales following correction for multiple comparisons.Conclusions
The highly specific screening tool ASRS-v1.1 can ascertain previously undetected ADHD symptoms in adults with CF. ADHD was substantially more prevalent than expected in this population. Elevated ASRS-v1.1 screens correlated with poorer Health-Related Quality of Life (HRQoL) in some domains, but not with BMI, FEV1%pred, or self-reported CF treatment adherence. Additional research will elucidate the impact of ADHD and its treatment on HRQoL, CF self-care and health outcomes. 相似文献5.
J.A. Scott S. McDermott A. Kilcoyne Y. Wang E.F. Halpern J.B. Ackman 《Clinical radiology》2019,74(9):692-696
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Branch-duct intraductal papillary mucinous neoplasms: observations in 145 patients who underwent resection 总被引：9，自引：0，他引：9
Rodriguez JR Salvia R Crippa S Warshaw AL Bassi C Falconi M Thayer SP Lauwers GY Capelli P Mino-Kenudson M Razo O McGrath D Pederzoli P Fernández-Del Castillo C 《Gastroenterology》2007,133(1):72-9; quiz 309-10
BACKGROUND & AIMS: Intraductal papillary mucinous neoplasms (IPMNs) of the pancreas arising in branch ducts are thought to be less aggressive than their main-duct counterparts, and guidelines for their conservative management were recently proposed. This study describes the combined experience of 2 tertiary centers with branch-duct IPMNs aiming to validate these recommendations. METHODS: A review of 145 patients with resected, pathologically confirmed, branch-duct IPMNs between 1990 and 2005 was conducted. RESULTS: Sixty-six patients (45.5%) had adenoma, 47 (32%) borderline tumors, 16 (11%) carcinoma in situ, and 16 (11%) invasive carcinoma. Median age was similar between benign and malignant subgroups (66 vs 67.5 years, respectively). Jaundice was more frequent in patients with cancer (12.5% vs 1.8%, respectively, P = .022) and abdominal pain in patients with benign tumors (45% vs 25%, respectively, P = .025). Forty percent of tumors were discovered incidentally. Findings associated with malignancy were the presence of a thick wall (P < .001), nodules (P < .001), and tumor diameter >or=30 mm (P < .001). All neoplasms with cancer were larger than 30 mm in size or had nodules or caused symptoms. After a mean follow-up of 45 months, the 5-year disease-specific survival for branch-duct IPMNs with noninvasive neoplasms was 100% and, for invasive cancer, was 63%. CONCLUSIONS: This large cohort of resected branch-duct IPMNs shows that cancer is present in 22% of cases and validates the recent guidelines that indicate absence of malignancy in tumors <30 mm, without symptoms or mural nodules. 相似文献
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Feiby L. Nassan Jorge E. Chavarro Lidia Mínguez-Alarcón Paige L. Williams Cigdem Tanrikut Jennifer B. Ford Ramace Dadd Melissa J. Perry Russ Hauser Audrey J. Gaskins 《International journal of hygiene and environmental health》2018,221(5):830-837