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1.
目的 探究高糖饮食对小鼠真菌性角膜炎的影响。方法 选取健康无眼疾的雄性C57BL/6J小鼠78只,随机分为高糖饮食组和模型对照组,每组36只,模型对照组给予正常饮用水,高糖饮食组给予含体积分数10%果糖溶液,每2 d测量两组小鼠体质量及血糖,10 d后建立真菌性角膜炎模型。造模后24 h、36 h、48 h、72 h、96 h、120 h、168 h裂隙灯显微镜下对角膜进行临床评分并拍照。处死小鼠后,取角膜组织进行HE染色和PAS染色;测定角膜内中性粒细胞和巨噬细胞浸润体积。利用酶联免疫吸附实验对小鼠角膜内的白细胞介素-1β含量进行测定。结果 造模后 0~14 d,两组小鼠体质量与血糖差异均无统计学意义(均为P>0.05)。造模后24 h、36 h、48 h、120 h、168 h,高糖饮食组小鼠角膜临床评分均明显高于模型对照组,差异均有统计学意义(均为P<0.05)。高糖饮食组小鼠角膜穿孔率79.5%,高于模型对照组的40.9%,差异有统计学意义(P=0.000)。造模后各时间点,高糖饮食组中性粒细胞浸润体积均高于模型对照组,差异均有统计学意义(均为P=0.000)。造模后72 h、96 h、120 h、168 h,高糖饮食组巨噬细胞浸润体积均高于模型对照组(均为P=0.000)。角膜组织病理学检查结果示,高糖饮食组炎症反应更重,角膜组织破坏更早且更为严重。造模后24 h、48 h高糖饮食组白细胞介素-1β含量均明显高于模型对照组(均为P<0.05)。结论 高糖饮食加重了真菌性角膜炎感染的严重程度,增强了中性粒细胞、巨噬细胞的趋化,促进了IL-1β的分泌。 相似文献
2.
Vassiliki Costarelli Maria Michou Demosthenes B. Panagiotakos Christos Lionis 《International journal of food sciences and nutrition》2021,72(1):112-122
AbstractThe study examines Parental Feeding Practices (PFP) in relation to adherence to the Mediterranean Diet (MD) and children’s weight status. It’s a cross-sectional study of 402 parents (68.4% mothers), with children aged 2–12 years. Parents completed the Comprehensive Parental Feeding Questionnaire and the Mediterranean Diet Quality Index for children and adolescents (KIDMED), evaluating children’s adherence to the MD. Logistic regression showed that in children aged 2–<6 years, “emotion regulation/food as reward” and “pressure” decrease MD adherence (OR?=?0.186, p?<?0.0001 and OR?=?0.496, p?=?0.004), and “monitoring” decrease excess body weight (OR?=?0.284, p?=?0.009). In older children (6–12 years), “healthy eating guidance” and “monitoring” increase MD adherence (OR?=?3.262, p?=?0.001 and OR?=?3.147, p?<?0.0001), “child control” decreases MD adherence (OR?=?0.587, p?=?0.049), “pressure” decrease excess body weight (OR?=?0.495, p?<?0.0001) and “restriction” increase excess body weight (OR?=?1.784, p?=?0.015). “Healthy eating guidance” and “monitoring” seem to be the best PFP employed, in terms of children’s MD adherence and weight status. 相似文献
3.
Judith Brock Andreas Schmid Thomas Karrasch Petra Pfefferle Jutta Schlegel Inga Busse Annette Hauenschild Barbara Schmidt Maria Koukou Efthymia Arapogianni Andreas Schultz Miriam Thomalla Secil Akinci Johannes Kruse Winfried Padberg Andreas Schffler Jens Albrecht 《Clinical endocrinology》2019,91(3):400-410
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B. A. Stoll 《Annals of oncology》1997,8(3):223-225
Background: The study reviews the anticancer properties of naturalisoflavones which occur in especially high concentration in soybeans. Itconsiders the suitability of soybean products for clinical trials aiming toreduce the progression of breast cancer.Methods: Evidence is reviewed that plant isoflavones such asgenistein show cytostatic activity against human mammary cancer cell linesin vitro and can also suppress carcinogen-induced mammary cancer inyoung and mature rats.Results: Plant isoflavones are converted in the bowel to compoundswith potential antioestrogenic and antioxidative properties. These compoundsshow cytostatic activity for both oestrogen receptor-positive and negativehuman mammary cancer cell lines, and also inhibit growth and progress of therat mammary cancer model. The high content of soybean products in the diet ofAsian women has been postulated as one reason for their relatively low breastcancer incidence.Conclusion: Preclinical studies suggest that soybean products begiven priority for clinical trials in breast cancer protection. A pilot studycould test soy protein supplements as long-term adjuvant dietary treatmentafter primary surgery for early breast cancer, looking for a decrease in therisk of recurrence or of second primary tumours. 相似文献
6.
亚低温治疗患者鼻饲营养并发症的观察及护理 总被引:4,自引:1,他引:3
报道48例亚低温治疗患者采用一次性投给、间歇滴注和连续输注营养膳的方式鼻饲营养,其并发症有:腹泻、腹胀、肠蠕动亢进,便秘,食物反流,吸入性肺炎,代谢紊乱,高血糖,水、电解质失衡,鼻胃管堵塞等。护理中体会到亚低温治疗患者鼻饲营养的时机最好在急性期1~2d后,应用鼻饲泵连续输注,适时使用胃肠动力药西沙比利.掌握营养膳的配制和正确的鼻饲方法,严密观察,发现异常及时处理,可大大降低并发症的发生。 相似文献
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8.
实验国际学校学生膳食及营养状况的调查 总被引:2,自引:0,他引:2
本文对南京实验国际学校369名6~11岁学生进行了膳食及营养状况的分析研究。结果表明:该校学生膳食中除视黄醇、钙及锌(9~11岁组)不足外,其余营养素和热能均超过推荐供应量。蛋白质量足质优。脂肪在一天总热能中比例较高.达到30%左右。该校学生营养过剩发生率达18.4%.提示该校食堂要注意学生膳食的合理调配.防止学生摄入过多脂肪和热能;同时建议增加含钙、锌高的食物供给,以补充其不足。 相似文献
9.
Transcriptional downregulation of tight junction protein ZO-1 in active coeliac disease is reversed after a gluten-free diet 总被引:1,自引:0,他引:1
10.
T. Dean† C. Venter† B. Pereira J. Grundy C. B. Clayton & B. Higgins† 《Journal of human nutrition and dietetics》2007,20(2):95-99
BACKGROUND: In 1998, the UK government issued precautionary advice that pregnant or breast-feeding women with a family history of atopy, may wish to avoid eating peanuts during pregnancy and lactation. This study aimed to assess the compliance with this recommendation and investigate its impact upon peanut sensitization. METHODS: A total of 858 children born immediately after the advice were followed for 2 years and assessed for peanut sensitization. A standardized questionnaire was used to ascertain history of atopy and maternal exposure to peanuts during pregnancy. Following parental consent children were skin prick tested to assess sensitization to peanuts. RESULTS: Sixty-five per cent of mothers had avoided peanuts during pregnancy. Forty-two per cent of the mothers had heard about the government advice, and half modified their diet as a consequence. Neither maternal nor family history of atopy had any significant effect on peanut consumption. Parity did play a role, and mothers having their first child were twice as likely to change their diet (P<0.001). Mothers of 77% of the children sensitized to peanuts had avoided peanuts during pregnancy. In this cohort study maternal consumption of peanut during pregnancy was not associated with peanut sensitization in the infant. CONCLUSIONS: The majority of mothers in this cohort avoided peanut consumption during pregnancy. It is likely that either the government advice is misunderstood by mothers, or that those who communicate the advice have not fully explained who it is targeted at. 相似文献