山葡萄籽油(EPC)调节血脂作用的研究

对长白山地区山葡萄籽油调节血脂作用进行了研究.建立Wistar大鼠高脂血症模型后,观察葡萄籽油调节血脂功能.结果15天后高剂量组具有很好的降脂作用,TC下降达17.5%.30天后小剂量和大剂量组均具有调节血脂的作用,TC、TG两项指标均下降15%以上,特别是大剂量组TC下降24.6%(P＜0.001),TG下降23%(P＜0.01).通过对大鼠的试验研究证实,EPC油具有调节血脂作用,且给药时间越长,效果越明显.     

银杏叶提取物对糖尿病的药效学研究

观察了银杏叶提取物（ＥＧｂ）对糖尿病大鼠的治疗作用。结果表明ＥＧｂ能降低正常大鼠血糖,但无明显的量效关系;使四氧嘧啶糖尿病大鼠血糖下降,血清胰岛素升高。对糖尿病大鼠的血脂代谢有显著的改善作用,使ＨＣＬ升高而ＴＧ、ＴＣ、ＬＤＬ值显著降低（Ｐ〈０．０１）。ＥＧｂ也能显著降低血清和组织中的脂质过氧化产物丙二醛（ＭＤＡ）含量（Ｐ〈０．０１）。因此ＥＧｂ对糖尿病有一定的治疗作用,其作用可能与ＥＧｂ促进胰岛β     

肥胖症患者血脂和微量元素水平及其临床意义

我们抽样检测了我国肥胖病患者血脂、微量元素及血压。结果发现肥胖症患者血压、血糖、低密度脂蛋白、极低密度脂蛋白、载脂蛋白Ｂ，血清锌、铁、钠、钙、镁及锌／铜、钠／钾比值明显高于正常组，而高密度脂蛋白及钙／镁比值明显低于正常组。结合本研究的结果，我们对血脂和血压与微量元素的关系进行了分析。     

血清幽门螺杆菌抗体检测与冠心病关系初探

观察６０例心病，４２例高血压患者和６０例正常人血清幽门螺杆菌抗体载脂蛋白Ｂ１００和脂刷 白（ａ）「Ｌｐ（ａ）」旨在探讨幽门螺杆菌感染在冠心病患者的感染情况以及同血脂代谢之间的关系。结论幽门杆菌菌感染可能是冠心病发病的独立危险因子，其机理可能是长甚是性感染引起ＡＰＯＢ１００、Ｌｐ（ａ）浓度增加，因而促发ＣＨＤ发生。     

咪唑普利对高血压患者血压及有关生化因素的影响

目的 评估ACEI咪唑普利(Imidapril)对原发性高血压患者的降压效果及对有关因素(包括血脂、内皮素等)的影响。方法 选择31例高血压患者服用咪唑普利5～10mg/日,连续4～6周,观察比较服药前后血压、心率、生化指标及内皮素含量。结果 服药后血压、心率、TC、LDL-C及内皮素显著降低,血肌酐及其它指标无明显变化。结论 咪唑普利具有良好的降压效果,无反射性心率加快,对血脂、血糖无不良影响,并能降低内皮素含量。     

自动监测样品状态在临床生化检测中的应用

目的拓展全自动生化分析仪的功能,利用其自动判别样品的脂血、黄疸与溶血(LIH)状态,比较其与传统的肉眼判定结果的差异。方法编制特定的LIH检测程序,采用生理盐水作测定LIH级别的试剂,每日监测样品的LIH状态,460余份异常者同时测定其三酰甘油(TG)、总胆红素(TB il)及血红蛋白(Hb)含量。将95份仪器判别为存在LIH的样品与30份明显LIH的样品进行单盲人工判别,比较两者的一致性。结果仪器与人工判别样品有无黄疸和溶血及其严重程度差异无显著性;2种方法判断脂血状态有一定差异,对低TG水平[(3.02±1.81)mmol/L]的样品判别两者符合率较低;但TG浓度较高[(8.77±5.34)mmol/L]的样品,两者的符合率可达93.33%。明显溶血[Hb为(4.23±1.65)g/L]与黄疸[TB il为(198.61±132.95)μmol/L]的样品,两法判别的符合率均为100%。结论采用仪器自动判别样品的LIH状态结果比传统的手工法更为可靠,同时又极大地提高检验工作效率,具有很好的实用价值。     

一体化管理对社区糖尿病患者糖化血红蛋白和血脂的影响研究

目的评价社区糖尿病一体化管理对糖尿病患者糖化血红蛋白(HbA1c)和血脂控制的效果,为糖尿病患者社区管理个体化方案提供依据。方法将入选的糖尿病患者分为试验组138例和对照组139例,对照组按照传统分组管理模式,社区公共卫生医生按组定期随访,患者自主就诊;试验组在此基础上,加强全科医生、糖尿病专科医生参与,实现"公共卫生医生-全科医生-专科医生"一体化无缝式管理模式,随访1年,比较两组的HbA1c和血脂指标的变化。结果与对照组比较,干预后试验组的平均HbA1c较对照组净下降0.89%,差异有统计学意义(P<0.01);血清三酰甘油(TG)明显下降,差异有统计学意义(P<0.01);血清总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)没有明显变化,差异无统计学意义(P>0.05)。结论一体化管理模式在改善HbA1c和血脂(特别是TG)方面存在更明显的优势。     

The fiber and/or polyphenols present in lingonberries null the glycemic effect of the sugars present in the berries when consumed together with added glucose in healthy human volunteers

This study was undertaken on the broad hypothesis that lingonberry (Vaccinium vitis-idaea L.) has potential to reduce postprandial glycemic and lipemic response. More specifically, 2 postprandial crossover studies with healthy normal-weight male subjects were conducted to study the influence of commercial lingonberry powder on postprandial glycemia and lipemia. The test meals contained fat-free yoghurt with either glucose (50 g) or triacylglycerols (35 g) with or without (control) the lingonberry powder. The lingonberry powder provided the meals with a known amount of fiber and a known amount and composition of sugars, and it was a rich source of polyphenols. Postprandial glucose, insulin, and triacylglycerol responses were analyzed. There were no significant differences in the postprandial glucose concentration between the meals in the glycemia trial despite the fact that the lingonberry meal contained more glucose and fructose. When the meal did not contain added sugar but, instead, added triacylglycerol, no glycemia or lipemia-lowering effect was detected. On the contrary, there were indications of higher glycemic and insulinemic effect after the lingonberry meal. The results of this study indicate that the fibers and/or polyphenols present in lingonberries null the glycemic effect of the sugars present in the berries when consumed together with added glucose. By contrast, the lingonberry powder did not affect the postprandial lipemic response.     

探讨标本状态对全血细胞检测结果的影响

目的:探讨标本状况对全血细胞分析结果的影响。方法:采用日本Sysmex KX-21N血细胞分析仪进行检测,对数例有脂血、黄疸、溶血、小红细胞等标本状况的检测结果进行分析;校正分别用白细胞和血小板稀释液稀释标本后,充入计数池内进行白细胞和血小板计数;脂血标本用等量生理盐水或稀释液洗涤后重测血红蛋白;由抽血引起的溶血标本重抽血,再行检测。结果:脂血标本血红蛋白明显升高,黄疸标本白细胞计数显著增高,小红细胞影响血小板假性增高,溶血标本红细胞和压积降低,与血红蛋白比例明显不符。结论:通过分析全血细胞检测结果各参数之间的关系,可找出影响其结果的因素,予以校正,加强审核结果的环节,为临床提供准确、可靠的检验结果。     

Hypertriglyceridemia-Induced Pancreatitis and a Lipemic Blood Sample: A Case Report and Brief Clinical Review

Hypertriglyceridemia is the third most common cause of acute pancreatitis after gallstones and long-term alcohol use. There are specific therapeutic options unique to hyperglyceridemia-induced pancreatitis, such as continuous insulin therapy and plasmapheresis, emphasizing the importance of identifying hypertriglyceridemia as the cause. Triglyceride levels > 1000 mg/dL may result in a visibly lipemic blood sample. Lipemic samples may interfere with laboratory equipment, resulting in erroneous levels or the inability to measure several serum blood tests. Consider hypertriglyceridemia as a cause for acute pancreatitis in the setting of a lipemic blood sample or when gallstones have been excluded.