铁剂联合补益类中药对改善缺铁性贫血症状的短期研究

目的：观察补血片及联合补益类中药改善缺铁性贫血症状的短期（15 d）效果.方法：将30例缺铁性贫血患者随机分为对照组和试验组（Ⅰ组、Ⅱ组）.对照组口服空白片,试验Ⅰ组口服补血片;试验Ⅱ组口服补血片加复力片.试验期为15 d,在开始和结束时分别测定受试者的Hb、FEP指标和台阶试验的SI指数.结果：试食15 d后,Ⅱ组的Hb水平和SI指数较试验前有显著性提高（P＜0.05）、FEP水平有极显著下降（P＜0.01）;Ⅰ组的HP水平亦有极显著下降（P＜0.01）,Hb水平和SI指数较试验前则差异无统计学意义（P＜0.05）.结论：补片血联合复力片能短期内（15d）迅速升高缺铁性贫血患者的Hb水平,提示铁剂联合补益类中药对改善缺铁性贫血症状比单独应用铁剂具有更明显的作用.     

缺铁性贫血患者输注PRC前后血清SF、FA和VitB12水平的临床意义

目的：探讨了缺铁性贫血（IDA）患者输注悬浮红细胞（PRC）前后血清铁蛋白（SF）、叶酸（FA）和维生素B12（VitB12）水平的变化。方法：应用放射免疫分析对32例缺铁性贫血患者进行了输注PRC前后血清SF、FA和VitB12水平测定,并以35名正常健康人作比较。结果：缺铁性贫血患者在输注PRC前血清SF水平非常显著地低于正常人组（P〈0.01）,而血清FA、VitB12水平显著高于正常人组（P〈0.01）,经治疗2周后除SF水平与正常人比较仍有差异外（P〈0.05）,而FA和VitB12水平则与正常人比较无显著性差异（P〉0.05）。结论：输注PRC对缺铁性贫血患者具有一定的治疗作用,有重要的临床价值。     

新型网织红细胞参数在缺铁性贫血疗效观察中的应用

目的　观察网织红细胞绝对数 (RET #)、网织红细胞内血红蛋白量 (CHr)、平均网织红细胞体积 (MCVr)及网织红细胞内血红蛋白浓度 (CHCMr)等网红参数在缺铁性贫血 (IDA)患者铁剂治疗中的动态变化 ,确定骨髓对铁剂治疗反应的早期指标。方法　用Advia 12 0血细胞分析仪对 13例缺铁性贫血患者在治疗过程中网红参数的变化进行了动态观察。结果　缺铁性贫血患者在铁剂治疗后 ,网红参数RET #、CHr、MCVr于第 4天明显升高 (P <0 0 1) ,第七天恢复正常 ;血红蛋白于第 14天明显升高 (P <0 0 1) ,第 2 8天恢复正常 ;CH、MCV、CHCM于第 2 8天明显升高 (P <0 0 1) ,第 4 9天后恢复正常 ;RDW于第 7天明显升高 (P <0 0 1) ,14天后又逐渐降低 ,第 12 0天恢复正常。结论　网红参数RET #、CHr、MCVr可作为评价缺铁性贫血患者铁剂治疗后骨髓对治疗反应最敏感的指标     

老年人缺铁性贫血100例病因分析

目的:探讨老年人缺铁性贫血(IDA)减少漏诊率。方法:回顾分析了老年组及中青年组各100例IDA的临床资料对比,并进行了血液学的检验,胃、结肠镜检查及幽门螺杆菌的检验,及病理等检查证实。结果:两组对比病因有明显的不同,中青年组以月经量过多为主,老年组以消化道疾病为主,胃镜检查HP阳性率占91%。结论:青年人的IDA病因简单,老年人的IDA病因复杂。     

Pattern of milk feeding and family size as risk factors for iron deficiency anemia among poor Egyptian infants 6 to 24 months old

Infants between 6 and 24 months of age are at the highest risk of development of iron deficiency anemia (IDA) in developing countries. Consuming unmodified cow's milk, delayed introduction of solid foods after 6 months, and high birth order could be predictors of the presence of IDA. Three hundred infants between the ages of 6 and 24 months (mean, 13.94 ± 6.17 months) from Ain Shams University Children's Hospital were enrolled in the study. Data collected included demographic information and dietary assessment including the type of milk feeding, introduction of solid foods, and daily iron intake. The infants were examined, and anthropometric measurements were recorded. Anemic infants (hemoglobin level <11 g/dL) were further evaluated by complete blood count, hemoglobin electrophoresis, and iron profile. Anemia was diagnosed among 198 infants (66%), of whom 129 (43%) had IDA. Red cell distribution width at a cutoff value of 15.8% was 86% sensitive and 74% specific in predicting IDA. The main risk factors for IDA included being between 6 and 18 months of age, of the male sex, birth order above the second order, consuming cow's milk, predominant breast-feeding beyond 6 months of age, and low daily iron intake. We conclude that IDA is the most common cause of anemia among Egyptian infants 6 to 24 months old of low socioeconomic standard. Independent clinical predictors were consuming cow's milk during the first 6 months, delayed introduction of solid foods after 6 months, and birth order beyond the second order.     

镇江市青少年学生青春前期缺铁性贫血及其影响因素分析

[目的]了解镇江市12～14岁青春前期青少年学生的缺铁性贫血状况及其影响因素，以便提出改进措施。[方法]采取随机分层整群抽样，对镇江市城区、农村学校12个班级的初一、初二的学生进行贫血实验检查及有关影响因素的问卷调查。[结果]镇江市12～14岁青少年学生缺铁性贫血患病率为29．4％（男20．8％、女38．4％）。多因素logistic分析其影响因素为性别、使用药物减肥、自我体重关注等。[结论]缺铁性贫血问题在镇江依然存在，要重视青少年学生的贫血问题，加强体重关注和膳食指导，使其养成良好的饮食习惯，合理膳食，均衡营养，确保他们健康成长。     

缺铁性贫血对幼儿生长发育的影响

[目的 ]　了解缺铁性贫血 (IDA)对幼儿生长发育的影响。 [方法 ]对 1997年 5月至 1999年 7月在济南市中心医院社区内实行档案化管理的 3 90名 1岁儿童按贫血与否分为IDA组 ( 180例 )和正常对照组 ( 2 10人 ) ,将其体格发育和丹佛小儿发育筛查 (DDST)结果进行对比分析。 [结果 ]IDA组体格发育略低于正常对照组 ,差异无显著性 (P >0 0 5 ) ;DDST项目通过率则IDA组明显低于对照组 ,有 9个项目差异有显著性 (P <0 0 1或P <0 0 5 )。 [结论 ]IDA对幼儿生长发育有严重影响 ,应引起家长和儿保工作者的高度重视。     

广东地区学龄前儿童膳食结构与缺铁性贫血的关系

本文对广东地区城乡学龄前儿童的膳食营养状况进行了调查研究,结果表明膳食中钙、视黄醇和核黄素摄入量偏低,与1982年全国营养调查的结果一致,有28.9％受检儿童的血红蛋白含量低于11g/dI的标准,说明缺铁性贫血仍是当前学龄前儿童普遍存在的营养问题。将儿童的血红蛋白水平与膳食构成中各种因素进行多元线性回归分析,结果显示线性回归方程有显著性(复相关系数R=0.7088F=7.46,P<0.01),说明血红蛋白水平与膳食构成各种因素之间有线性相关,其中与可吸收铁量和总铁摄入量的相关最为密切(相关系数r分别为0.6176和0.5412,P<0.01)。提示通过改善膳食结构可以预防缺铁性贫血的发生。本文还调查分析了不同膳食水平幼儿园的膳食构成与贫血发生率的关系,并观察了进行膳食指导和改善膳食构成的效果。同时观察了用铁强化食品补充膳食中总铁摄入量防治缺铁性贫血的效果。     

当归多糖铁复合物在缺铁性贫血大鼠与正常大鼠体内药动学比较研究

目的比较当归多糖铁复合物 (APIC) 在缺铁性贫血大鼠与正常大鼠体内的药动学差异,为优化临床给药方案提供参考。方法采用低铁饲料并辅以定期放血法建立缺铁性贫血模型,缺铁性贫血大鼠与正常大鼠分别随机分为 APIC 低、中、高剂量 (5.83、8.75、17.5 mg/kg) 组,ig 给药,以原子吸收法测定各时间点血清铁浓度,用 DAS 2.0 软件求算药动学参数,并采用 SPSS 13.0 软件对同剂量组的缺铁性贫血大鼠和正常大鼠的主要药动学参数进行 t 检验。结果APIC 在两种不同生理状况下大鼠的药动学过程均符合二室模型,3个剂量组的缺铁性贫血大鼠的血清铁浓度在 4 h 以后均显著高于健康大鼠,3个剂量组的 CL/F、t1/2β与正常组均有显著差异 (P＜0.05),但只有高剂量组的 t1/2α 与正常组有显著差异。结论APIC 在缺铁性贫血大鼠与正常大鼠体内的药动学存在显著差异,并且这种差异与剂量有一定的关系。     

Immunology of Helicobacter pylori: insights into the failure of the immune response and perspectives on vaccine studies

Helicobacter pylori infects the stomach of half of the human population worldwide and causes chronic active gastritis, which can lead to peptic ulcer disease, gastric adenocarcinoma, and mucosa-associated lymphoid tissue lymphoma. The host immune response to the infection is ineffective, because the bacterium persists and the inflammation continues for decades. Bacterial activation of epithelial cells, dendritic cells, monocytes, macrophages, and neutrophils leads to a T helper cell 1 type of adaptive response, but this remains inadequate. The host inflammatory response has a key functional role in disrupting acid homeostasis, which impacts directly on the colonization patterns of H pylori and thus the extent of gastritis. Many potential mechanisms for the failure of the host response have been postulated, and these include apoptosis of epithelial cells and macrophages, inadequate effector functions of macrophages and dendritic cells, VacA inhibition of T-cell function, and suppressive effects of regulatory T cells. Because of the extent of the disease burden, many strategies for prophylactic or therapeutic vaccines have been investigated. The goal of enhancing the host's ability to generate protective immunity has met with some success in animal models, but the efficacy of potential vaccines in humans remains to be demonstrated. Aspects of H pylori immunopathogenesis are reviewed and perspectives on the failure of the host immune response are discussed. Understanding the mechanisms of immune evasion could lead to new opportunities for enhancing eradication and prevention of infection and associated disease.